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Recent research has shown the potential for neural networks to improve upon classical survival models such as the Cox model, which is widely used in clinical practice. Neural networks, however, typically rely on data that are centrally…

Machine Learning · Computer Science 2022-07-12 Dekai Zhang , Francesca Toni , Matthew Williams

In this paper, we expand the methodology presented in Mertens et. al (2020, Biometrical Journal) to the study of life-time (survival) outcome which is subject to censoring and when imputation is used to account for missing values. We…

Methodology · Statistics 2021-05-06 Bart J. A. Mertens

It is common practice in statistical data analysis to perform data-driven variable selection and derive statistical inference from the resulting model. Such inference enjoys none of the guarantees that classical statistical theory provides…

Statistics Theory · Mathematics 2013-06-06 Richard Berk , Lawrence Brown , Andreas Buja , Kai Zhang , Linda Zhao

Applying standard statistical methods after model selection may yield inefficient estimators and hypothesis tests that fail to achieve nominal type-I error rates. The main issue is the fact that the post-selection distribution of the data…

Methodology · Statistics 2019-05-23 Amit Meir , Mathias Drton

We consider the problem of estimating the distribution of time-to-event data that are subject to censoring and for which the event of interest might never occur, i.e., some subjects are cured. To model this kind of data in the presence of…

Statistics Theory · Mathematics 2018-06-05 François Portier , Ingrid Van Keilegom , Anouar El Ghouch

The proportional hazards assumption in the commonly used Cox model for censored failure time data is often violated in scientific studies. Yang and Prentice (2005) proposed a novel semiparametric two-sample model that includes the…

Methodology · Statistics 2012-06-06 Guoqing Diao , Donglin Zeng , Song Yang

A new method for the analysis of time to ankylosis complication on a dataset of replanted teeth is proposed. In this context of left-censored, interval-censored and right-censored data, a Cox model with piecewise constant baseline hazard is…

Methodology · Statistics 2020-10-15 Olivier Bouaziz , Eva Lauridsen , Grégory Nuel

In biometrics and related fields, the Cox proportional hazards model are widely used to analyze with covariate adjustment. However, when some covariates are not observed, an unbiased estimator usually cannot be obtained. Even if there are…

Methodology · Statistics 2022-06-06 Shunichiro Orihara

This work proposes new inference methods for a regression coefficient of interest in a (heterogeneous) quantile regression model. We consider a high-dimensional model where the number of regressors potentially exceeds the sample size but a…

Statistics Theory · Mathematics 2017-10-05 Alexandre Belloni , Victor Chernozhukov , Kengo Kato

This paper develops a new approach to post-selection inference for screening high-dimensional predictors of survival outcomes. Post-selection inference for right-censored outcome data has been investigated in the literature, but much…

Methodology · Statistics 2021-12-22 Tzu-Jung Huang , Alex Luedtke , Ian W. McKeague

It is common to show the confidence intervals or $p$-values of selected features, or predictor variables in regression, but they often involve selection bias. The selective inference approach solves this bias by conditioning on the…

Methodology · Statistics 2022-06-02 Yoshikazu Terada , Hidetoshi Shimodaira

After selection with the Group LASSO (or generalized variants such as the overlapping, sparse, or standardized Group LASSO), inference for the selected parameters is unreliable in the absence of adjustments for selection bias. In the…

Methodology · Statistics 2022-08-16 Snigdha Panigrahi , Peter W. MacDonald , Daniel Kessler

The partial linear Cox model for interval-censoring is well-studied under the additive assumption but is still under-investigated without this assumption. In this paper, we propose to use a deep ReLU neural network to estimate the…

Methodology · Statistics 2023-07-04 Jie Zhou , Yue Zhang , Zhangsheng Yu

Fulfilling the promise of precision medicine requires accurately and precisely classifying disease states. For cancer, this includes prediction of survival time from a surfeit of covariates. Such data presents an opportunity for improved…

Applications · Statistics 2017-06-22 Shannon R. McCurdy , Annette Molinaro , Lior Pachter

In a Cox model, the partial likelihood, as the product of a series of conditional probabilities, is used to estimate the regression coefficients. In practice, those conditional probabilities are approximated by risk score ratios based on a…

Methodology · Statistics 2025-02-27 Youngjin Cho , Yili Hong , Pang Du

We study tools for inference conditioned on model selection events that are defined by the generalized lasso regularization path. The generalized lasso estimate is given by the solution of a penalized least squares regression problem, where…

Methodology · Statistics 2016-06-14 Sangwon Hyun , Max G'Sell , Ryan J. Tibshirani

Variable selection in high dimensional space has challenged many contemporary statistical problems from many frontiers of scientific disciplines. Recent technology advance has made it possible to collect a huge amount of covariate…

Machine Learning · Statistics 2010-05-20 Jianqing Fan , Yang Feng , Yichao Wu

Most work in neural networks focuses on estimating the conditional mean of a continuous response variable given a set of covariates.In this article, we consider estimating the conditional distribution function using neural networks for both…

Methodology · Statistics 2022-07-07 Bingqing Hu , Bin Nan

We develop a Monte Carlo-free approach to inference post output from randomized algorithms with a convex loss and a convex penalty. The pivotal statistic based on a truncated law, called the selective pivot, usually lacks closed form…

Methodology · Statistics 2017-05-19 Snigdha Panigrahi , Jelena Markovic , Jonathan Taylor

We develop tools for selective inference in the setting of group sparsity, including the construction of confidence intervals and p-values for testing selected groups of variables. Our main technical result gives the precise distribution of…

Methodology · Statistics 2016-07-28 Fan Yang , Rina Foygel Barber , Prateek Jain , John Lafferty