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Diffusion-based generative models have shown promise in synthesizing histopathology images to address data scarcity caused by privacy constraints. Diagnostic text reports provide high-level semantic descriptions, and masks offer…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Mahesh Bhosale , Abdul Wasi , Yuanhao Zhai , Yunjie Tian , Samuel Border , Nan Xi , Pinaki Sarder , Junsong Yuan , David Doermann , Xuan Gong

Medical image synthesis plays a crucial role in clinical workflows, addressing the common issue of missing imaging modalities due to factors such as extended scan times, scan corruption, artifacts, patient motion, and intolerance to…

Image and Video Processing · Electrical Eng. & Systems 2025-07-23 Xiaojiao Xiao , Qinmin Vivian Hu , Guanghui Wang

Recent advancements in deep learning for medical image segmentation are often limited by the scarcity of high-quality training data.While diffusion models provide a potential solution by generating synthetic images, their effectiveness in…

Computer Vision and Pattern Recognition · Computer Science 2025-07-02 Jianhao Xie , Ziang Zhang , Zhenyu Weng , Yuesheng Zhu , Guibo Luo

Pseudo-healthy image inpainting is an essential preprocessing step for analyzing pathological brain MRI scans. Most current inpainting methods favor slice-wise 2D models for their high in-plane fidelity, but their independence across slices…

Image and Video Processing · Electrical Eng. & Systems 2025-07-25 Dou Hoon Kwark , Shirui Luo , Xiyue Zhu , Yudu Li , Zhi-Pei Liang , Volodymyr Kindratenko

In the realm of high-resolution (HR), fine-grained image segmentation, the primary challenge is balancing broad contextual awareness with the precision required for detailed object delineation, capturing intricate details and the finest…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Qian Yu , Peng-Tao Jiang , Hao Zhang , Jinwei Chen , Bo Li , Lihe Zhang , Huchuan Lu

Dataset expansion can effectively alleviate the problem of data scarcity for medical image segmentation, due to privacy concerns and labeling difficulties. However, existing expansion algorithms still face great challenges due to their…

Image and Video Processing · Electrical Eng. & Systems 2023-06-07 Shitong Shao , Xiaohan Yuan , Zhen Huang , Ziming Qiu , Shuai Wang , Kevin Zhou

Synthesizing high-resolution images from intricate, domain-specific information remains a significant challenge in generative modeling, particularly for applications in large-image domains such as digital histopathology and remote sensing.…

Computer Vision and Pattern Recognition · Computer Science 2024-07-23 Minh-Quan Le , Alexandros Graikos , Srikar Yellapragada , Rajarsi Gupta , Joel Saltz , Dimitris Samaras

This paper introduces $\infty$-Diff, a generative diffusion model defined in an infinite-dimensional Hilbert space, which can model infinite resolution data. By training on randomly sampled subsets of coordinates and denoising content only…

Machine Learning · Computer Science 2024-03-04 Sam Bond-Taylor , Chris G. Willcocks

Visual microscopic study of diseased tissue by pathologists has been the cornerstone for cancer diagnosis and prognostication for more than a century. Recently, deep learning methods have made significant advances in the analysis and…

Image and Video Processing · Electrical Eng. & Systems 2022-09-30 Puria Azadi Moghadam , Sanne Van Dalen , Karina C. Martin , Jochen Lennerz , Stephen Yip , Hossein Farahani , Ali Bashashati

Diffusion models have revolutionized image generation, yet several challenges restrict their application to large-image domains, such as digital pathology and satellite imagery. Given that it is infeasible to directly train a model on…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Srikar Yellapragada , Alexandros Graikos , Kostas Triaridis , Prateek Prasanna , Rajarsi R. Gupta , Joel Saltz , Dimitris Samaras

Medical image segmentation models struggle with rare abnormalities due to scarce annotated pathological data. We propose DiffAug a novel framework that combines textguided diffusion-based generation with automatic segmentation validation to…

Computer Vision and Pattern Recognition · Computer Science 2025-08-26 Maham Nazir , Muhammad Aqeel , Francesco Setti

Foundation models in digital pathology use massive datasets to learn useful compact feature representations of complex histology images. However, there is limited transparency into what drives the correlation between dataset size and…

Histopathology can help clinicians make accurate diagnoses, determine disease prognosis, and plan appropriate treatment strategies. As deep learning techniques prove successful in the medical domain, the primary challenges become limited…

Computer Vision and Pattern Recognition · Computer Science 2024-07-11 Zhe Li , Bernhard Kainz

Synthetic data generation in histopathology faces unique challenges: preserving tissue heterogeneity, capturing subtle morphological features, and scaling to unannotated datasets. We present a latent diffusion model that generates realistic…

Computer Vision and Pattern Recognition · Computer Science 2025-10-03 Saghir Alfasly , Wataru Uegami , MD Enamul Hoq , Ghazal Alabtah , H. R. Tizhoosh

Solving medical imaging data scarcity through semantic image generation has attracted growing attention in recent years. However, existing generative models mainly focus on synthesizing whole-organ or large-tissue structures, showing…

Image and Video Processing · Electrical Eng. & Systems 2025-12-19 Jiahao Xia , Yutao Hu , Yaolei Qi , Zhenliang Li , Wenqi Shao , Junjun He , Ying Fu , Longjiang Zhang , Guanyu Yang

Nuclei segmentation and classification is a significant process in pathology image analysis. Deep learning-based approaches have greatly contributed to the higher accuracy of this task. However, those approaches suffer from the imbalanced…

Computer Vision and Pattern Recognition · Computer Science 2023-06-27 Hyun-Jic Oh , Won-Ki Jeong

Accurate quantification of the extent of lung pathological patterns (fibrosis, ground-glass opacity, emphysema, consolidation) is prerequisite for diagnosis and follow-up of interstitial lung diseases. However, segmentation is challenging…

Image and Video Processing · Electrical Eng. & Systems 2025-01-08 Rezkellah Noureddine Khiati , Pierre-Yves Brillet , Radu Ispas , Catalin Fetita

Diffusion models have emerged as the leading approach for image synthesis, demonstrating exceptional photorealism and diversity. However, training diffusion models at high resolutions remains computationally prohibitive, and existing…

Computer Vision and Pattern Recognition · Computer Science 2025-06-26 Tobias Vontobel , Seyedmorteza Sadat , Farnood Salehi , Romann M. Weber

We present DiffCollage, a compositional diffusion model that can generate large content by leveraging diffusion models trained on generating pieces of the large content. Our approach is based on a factor graph representation where each…

Computer Vision and Pattern Recognition · Computer Science 2023-03-31 Qinsheng Zhang , Jiaming Song , Xun Huang , Yongxin Chen , Ming-Yu Liu

Large-scale, big-variant, high-quality data are crucial for developing robust and successful deep-learning models for medical applications since they potentially enable better generalization performance and avoid overfitting. However, the…

Computer Vision and Pattern Recognition · Computer Science 2024-12-17 Zheyuan Zhang , Lanhong Yao , Bin Wang , Debesh Jha , Gorkem Durak , Elif Keles , Alpay Medetalibeyoglu , Ulas Bagci
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