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Mass spectrometry of intact nanoparticles and viruses can serve as a potent characterization tool for material science and biophysics. Inaccessible by widespread commercial techniques, the mass of single nanoparticles and viruses (>10MDa)…

Nanoelectromechanical Systems (NEMS) have emerged as a promising technology for performing the mass spectrometry of large biomolecules and nanoparticles. As nanoscale objects land on NEMS sensor one by one, they induce resolvable shifts in…

Mesoscale and Nanoscale Physics · Physics 2019-07-24 Mert Yuksel , Ezgi Orhan , Cenk Yanik , Atakan B. Ari , Alper Demir , M. Selim Hanay

Current approaches to Mass Spectrometry (MS) require ionization of the analytes of interest. For high-mass species, the resulting charge state distribution can be complex and difficult to interpret correctly. In this article, using a setup…

We describe the application of nanoelectromechanical systems (NEMS) to ultrasensitive mass detection. In these experiments, a modulated flux of atoms was adsorbed upon the surface of a 32.8 MHz NEMS resonator within an ultrahigh vacuum…

Other Condensed Matter · Physics 2009-11-10 K. L. Ekinci , X. M. H. Huang , M. L. Roukes

One of the main challenges to overcome to perform nanomechanical Mass Spectrometry (NEMS-MS) analysis in a practical time frame stems from the size mismatch between the analyte beam and the extremely small nanomechanical detector area. We…

Nanoelectromechanical systems (NEMS) have generated considerable interest as inertial mass sensors. NEMS resonators have been used to weigh cells, biomolecules, and gas molecules, creating many new possibilities for biological and chemical…

Mesoscale and Nanoscale Physics · Physics 2012-04-13 J. Chaste , A. Eichler , J. Moser , G. Ceballos , R. Rurali , A. Bachtold

Nanomechanical spectroscopy (NMS) is a recently developed approach to determine optical absorption spectra of nanoscale materials via mechanical measurements. It is based on measuring changes in the resonance frequency of a membrane…

Nanoelectromechanical systems, or NEMS, are MEMS scaled to submicron dimensions. In this size regime, it is possible to attain extremely high fundamental frequencies while simultaneously preserving very high mechanical responsivity (small…

Mesoscale and Nanoscale Physics · Physics 2007-05-23 M. L. Roukes

Most technologies, including conventional mass spectrometry, struggle to measure the mass of particles in the MDa to GDa range. Although this mass range appears optimal for nanomechanical resonators, early nanomechanical-MS systems suffered…

Nanomechanical sensors and quantum nanosensors are two rapidly developing technologies that have diverse interdisciplinary applications in biological and chemical analysis and microscopy. For example, nanomechanical sensors based upon…

Nanoelectromechanical systems (NEMS) are nano-to-micrometer scale mechanical resonators coupled to electronic devices of similar dimensions. NEMS show promise for fast, ultrasensitive force microscopy and for deepening our understanding of…

Mesoscale and Nanoscale Physics · Physics 2015-06-25 M. P. Blencowe

Nanoelectromechanical systems (NEMSs) are emerging nanoscale elements at the crossroads between mechanics, optics and electronics, with significant potential for actuation and sensing applications. The reduction of dimensions compared to…

Mesoscale and Nanoscale Physics · Physics 2012-03-20 Antoine Reserbat-Plantey , Laetitia Marty , Olivier Arcizet , Nedjma Bendiab , Vincent Bouchiat

Nanoelectromechanical systems (NEMS) have proven outstanding performance in the detection of small masses down to single proton sensitivity. To obtain a high enough throughput for the application in practical mass spectrometry, NEMS…

Applied Physics · Physics 2023-03-14 Hendrik Kähler , Robert Winkler , Holger Arthaber , Harald Plank , Silvan Schmid

It has been demonstrated in the recent years that nanomechanical mass spectrometry was well suited for the analysis of specific high mass species such as viruses. Still, the exclusive use of one-dimensional devices such as vibrating beams…

Nanoparticles (NPs) are widely used in diverse application areas, such as medicine, engineering, and cosmetics. The size (or volume) of NPs is one of the most important parameters for their successful application. It is relatively…

Mesoscale and Nanoscale Physics · Physics 2016-06-06 Ravi Kiran Attota

Currently the extent of nanoplastic in the environment can only be estimated by extrapolation from the plastic waste that can be detected. To be able to quantify the whole extent of the problem, detection methods have to be developed that…

Optics · Physics 2025-11-12 Ambika Shorny , Fritz Steiner , Helmut Hörner , Sarah M. Skoff

Near Ambient Pressure Scanning Photoelectron Microscopy adds to the widely used photoemission spectroscopy and its chemically selective capability two key features: (i) the possibility to chemically analyse samples in a more realistic…

We demonstrate a class of model nano-electromechanical systems (NEMS) based on multiwalled carbon nanotubes (MWNTs) which has longer inner cores coaxially oscillating inside their respective shorter outer shell holders and can operate at…

Materials Science · Physics 2007-09-26 Quan-shui Zheng , Zhiping Xu , Adrian Neild , Tuck Wah Ng

This paper investigates the performance of the micro-electro-mechanical systems resonant sensor used for particle detection and concentration measurement. These fine and ultra-fine particles such as particulate matter (PM), ferrous…

Instrumentation and Detectors · Physics 2021-12-21 Vinayak Pachkawade , Zion Tse

Aberration-corrected environmental transmission electron microscopy (ETEM) enables atomic-resolution imaging of dynamic catalytic processes. Correlating atomic-scale structural changes with reaction products detected by mass spectrometry…

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