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Generative pre-trained Transformer (GPT) has demonstrates its great success in natural language processing and related techniques have been adapted into molecular modeling. Considering that text is the most important record for scientific…

Computation and Language · Computer Science 2023-05-29 Zequn Liu , Wei Zhang , Yingce Xia , Lijun Wu , Shufang Xie , Tao Qin , Ming Zhang , Tie-Yan Liu

Zero-shot graph machine learning, especially with graph neural networks (GNNs), has garnered significant interest due to the challenge of scarce labeled data. While methods like self-supervised learning and graph prompt learning have been…

Machine Learning · Computer Science 2024-12-20 Duo Wang , Yuan Zuo , Fengzhi Li , Junjie Wu

Recent advancements in computational chemistry have increasingly focused on synthesizing molecules based on textual instructions. Integrating graph generation with these instructions is complex, leading most current methods to use molecular…

Machine Learning · Computer Science 2025-08-27 Yuran Xiang , Haiteng Zhao , Chang Ma , Zhi-Hong Deng

Generalizing to unseen graph tasks without task-specific supervision is challenging: conventional graph neural networks are typically tied to a fixed label space, while large language models (LLMs) struggle to capture graph structure. We…

Machine Learning · Computer Science 2025-10-21 Duo Wang , Yuan Zuo , Guangyue Lu , Junjie Wu

Representation learning on text-attributed graphs (TAGs), where nodes are represented by textual descriptions, is crucial for textual and relational knowledge systems and recommendation systems. Currently, state-of-the-art embedding methods…

Computation and Language · Computer Science 2024-12-24 Yi Fang , Dongzhe Fan , Sirui Ding , Ninghao Liu , Qiaoyu Tan

Graph Neural Networks (GNNs) are powerful tools for processing relational data but often struggle to generalize to unseen graphs, giving rise to the development of Graph Foundational Models (GFMs). However, current GFMs are challenged by…

Machine Learning · Computer Science 2026-05-25 Weishuo Ma , Yanbo Wang , Xiyuan Wang , Lei Zou , Muhan Zhang

Large language models (LLMs) have demonstrated their strong capabilities in various domains, and have been recently integrated for graph analysis as graph language models (GLMs). With LLMs as the predictor, some GLMs can interpret unseen…

Computation and Language · Computer Science 2025-06-30 Junze Chen , Cheng Yang , Shujie Li , Zhiqiang Zhang , Yawen Li , Junping Du , Chuan Shi

Graph Neural Networks (GNNs) have evolved to understand graph structures through recursive exchanges and aggregations among nodes. To enhance robustness, self-supervised learning (SSL) has become a vital tool for data augmentation.…

Computation and Language · Computer Science 2024-05-08 Jiabin Tang , Yuhao Yang , Wei Wei , Lei Shi , Lixin Su , Suqi Cheng , Dawei Yin , Chao Huang

The remarkable success of Large Language Models (LLMs) across diverse tasks has driven the research community to extend their capabilities to molecular applications. However, most molecular LLMs employ adapter-based architectures that do…

Computation and Language · Computer Science 2025-06-24 Shuhan Guo , Yatao Bian , Ruibing Wang , Nan Yin , Zhen Wang , Quanming Yao

Foundation models like ChatGPT and GPT-4 have revolutionized artificial intelligence, exhibiting remarkable abilities to generalize across a wide array of tasks and applications beyond their initial training objectives. However, graph…

Machine Learning · Computer Science 2025-01-22 Yufei He , Yuan Sui , Xiaoxin He , Bryan Hooi

Machine learning techniques have recently been adopted in various applications in medicine, biology, chemistry, and material engineering. An important task is to predict the properties of molecules, which serves as the main subroutine in…

Machine Learning · Computer Science 2019-11-12 Shengchao Liu , Mehmet Furkan Demirel , Yingyu Liang

Understanding molecular structure and related knowledge is crucial for scientific research. Recent studies integrate molecular graphs with their textual descriptions to enhance molecular representation learning. However, they focus on the…

Artificial Intelligence · Computer Science 2025-06-02 Yibo Li , Yuan Fang , Mengmei Zhang , Chuan Shi

Large language models have made significant strides in natural language processing, enabling innovative applications in molecular science by processing textual representations of molecules. However, most existing language models cannot…

Machine Learning · Computer Science 2024-02-07 Pengfei Liu , Yiming Ren , Jun Tao , Zhixiang Ren

Meta-training, which fine-tunes the language model (LM) on various downstream tasks by maximizing the likelihood of the target label given the task instruction and input instance, has improved the zero-shot task generalization performance.…

Computation and Language · Computer Science 2023-06-07 Seonghyeon Ye , Doyoung Kim , Joel Jang , Joongbo Shin , Minjoon Seo

Molecular language modeling tasks such as molecule captioning have been recognized for their potential to further understand molecular properties that can aid drug discovery or material synthesis based on chemical reactions. Unlike the…

Machine Learning · Computer Science 2025-03-12 Sangyeup Kim , Nayeon Kim , Yinhua Piao , Sun Kim

Small molecules are essential to drug discovery, and graph-language models hold promise for learning molecular properties and functions from text. However, existing molecule-text datasets are limited in scale and informativeness,…

Biomolecules · Quantitative Biology 2025-06-03 Yihan Zhu , Gang Liu , Eric Inae , Meng Jiang

This paper studies learning on text-attributed graphs (TAGs), where each node is associated with a text description. An ideal solution for such a problem would be integrating both the text and graph structure information with large language…

Machine Learning · Computer Science 2023-03-02 Jianan Zhao , Meng Qu , Chaozhuo Li , Hao Yan , Qian Liu , Rui Li , Xing Xie , Jian Tang

Large Language Models (LLMs) have demonstrated strong capabilities in various natural language processing tasks; however, their application to graph-related problems remains limited, primarily due to scalability constraints and the absence…

Machine Learning · Computer Science 2025-05-08 Hyun Lee , Chris Yi , Maminur Islam , B. D. S. Aritra

Graphs with abundant attributes are essential in modeling interconnected entities and enhancing predictions across various real-world applications. Traditional Graph Neural Networks (GNNs) often require re-training for different graph tasks…

Computation and Language · Computer Science 2026-05-26 Yanchao Tan , Hang Lv , Pengxiang Zhan , Shiping Wang , Carl Yang

Pretrained language models (PLMs) have demonstrated remarkable performance in various natural language processing tasks: Unidirectional PLMs (e.g., GPT) are well known for their superior text generation capabilities; bidirectional PLMs…

Computation and Language · Computer Science 2022-10-13 Yu Meng , Jiaxin Huang , Yu Zhang , Jiawei Han
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