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Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, primarily affecting the elderly population and leading to significant cognitive decline. This decline manifests in various mental faculties such as attention,…

Machine Learning · Computer Science 2025-04-22 Emine Akpinar

Alzheimer's Disease is an incurable cognitive condition that affects thousands of people globally. While some diagnostic methods exist for Alzheimer's Disease, many of these methods cannot detect Alzheimer's in its earlier stages. Recently,…

Neural and Evolutionary Computing · Computer Science 2024-09-12 Akshay Sunkara , Sriram Sattiraju , Aakarshan Kumar , Zaryab Kanjiani , Himesh Anumala

Alzheimer's Disease (AD) is marked by significant inter-individual variability in its progression, complicating accurate prognosis and personalized care planning. This heterogeneity underscores the critical need for predictive models…

Machine Learning · Computer Science 2025-05-01 Gulsah Hancerliogullari Koksalmis , Bulent Soykan , Laura J. Brattain , Hsin-Hsiung Huang

Current neuroimaging techniques provide paths to investigate the structure and function of the brain in vivo and have made great advances in understanding Alzheimer's disease (AD). However, the group-level analyses prevalently used for…

Quantitative Methods · Quantitative Biology 2021-05-31 Nanyan Zhu , Chen Liu , Xinyang Feng , Dipika Sikka , Sabrina Gjerswold-Selleck , Scott A. Small , Jia Guo

Early prognosis of Alzheimer's dementia is hard. Mild cognitive impairment (MCI) typically precedes Alzheimer's dementia, yet only a fraction of MCI individuals will progress to dementia, even when screened using biomarkers. We propose here…

Quantitative Methods · Quantitative Biology 2018-03-05 Christian Dansereau , Angela Tam , AmanPreet Badhwar , Sebastian Urchs , Pierre Orban , Pedro Rosa-Neto , Pierre Bellec

Language is a valuable source of clinical information in Alzheimer's Disease, as it declines concurrently with neurodegeneration. Consequently, speech and language data have been extensively studied in connection with its diagnosis. This…

Artificial Intelligence · Computer Science 2020-10-14 Sofia de la Fuente Garcia , Craig Ritchie , Saturnino Luz

An interpretable machine learning (ML) framework is introduced to enhance the diagnosis of Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) by ensuring robustness of the ML models' interpretations. The dataset used comprises…

Dementia is a collection of symptoms associated with impaired cognition and impedes everyday normal functioning. Dementia, with Alzheimer's disease constituting its most common type, is highly complex in terms of etiology and…

In order to find effective treatments for Alzheimer's disease (AD), we need to identify subjects at risk of AD as early as possible. To this end, recently developed disease progression models can be used to perform early diagnosis, as well…

Quantitative Methods · Quantitative Biology 2020-03-11 Razvan V. Marinescu

Alzheimer's Disease (AD) is a neurodegenerative disease that affects subjects in a broad range of severity and is assessed in clinical trials with multiple cognitive and functional instruments. As clinical trials in AD increasingly focus on…

Alzheimers Disease (AD) is a progressive neurodegenerative disorder that poses significant challenges in its early diagnosis, often leading to delayed treatment and poorer outcomes for patients. Traditional diagnostic methods, typically…

Machine Learning · Computer Science 2025-08-06 Tatwadarshi P Nagarhalli , Sanket Patil , Vishal Pande , Uday Aswalekar , Prafulla Patil

Deep learning has been recently used for the analysis of neuroimages, such as structural magnetic resonance imaging (MRI), functional MRI, and positron emission tomography (PET), and has achieved significant performance improvements over…

Image and Video Processing · Electrical Eng. & Systems 2020-05-12 Li Zhang , Mingliang Wang , Mingxia Liu , Daoqiang Zhang

Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by the accumulation of amyloid-beta (A$\beta$) and phosphorylated tau (p-tau) proteins, leading to cognitive decline measured by the Alzheimer's Disease…

Neurons and Cognition · Quantitative Biology 2025-04-21 Swadesh Pal , Roderick Melnik

Alzheimer's Disease (AD) is the most common type of dementia. In all leading countries, it is one of the primary reasons of death in senior citizens. Currently, it is diagnosed by calculating the MSME score and by the manual study of MRI…

Machine Learning · Computer Science 2019-12-11 Rishu Garg , Rekh Ram Janghel , Yogesh Rathore

Deep learning methods based on Convolutional Neural Networks (CNNs) have shown great potential to improve early and accurate diagnosis of Alzheimer's disease (AD) dementia based on imaging data. However, these methods have yet to be widely…

Computer Vision and Pattern Recognition · Computer Science 2025-01-22 Wenjie Kang , Lize Jiskoot , Peter De Deyn , Geert Biessels , Huiberdina Koek , Jurgen Claassen , Huub Middelkoop , Wiesje Flier , Willemijn J. Jansen , Stefan Klein , Esther Bron

With populations ageing, the number of people with dementia worldwide is expected to triple to 152 million by 2050. Seventy percent of cases are due to Alzheimer's disease (AD) pathology and there is a 10-20 year 'pre-clinical' period…

Artificial Intelligence · Computer Science 2021-04-30 Renjie Li , Xinyi Wang , Katherine Lawler , Saurabh Garg , Quan Bai , Jane Alty

Alzheimer's, an old age disease of people over 65 years causes problems with memory, thinking and behavior. This disease progresses very slow and its identification in early stages is very difficult. The symptoms of Alzheimer's appear…

Computer Vision and Pattern Recognition · Computer Science 2013-05-15 Ijaz Bukhari

Alzheimer's Disease (AD) is a complex neurodegenerative disorder marked by memory loss, executive dysfunction, and personality changes. Early diagnosis is challenging due to subtle symptoms and varied presentations, often leading to…

Computer Vision and Pattern Recognition · Computer Science 2025-01-06 Yifei Chen , Shenghao Zhu , Zhaojie Fang , Chang Liu , Binfeng Zou , Yuhe Wang , Shuo Chang , Fan Jia , Feiwei Qin , Jin Fan , Yong Peng , Changmiao Wang

Cognitive decline is a sign of Alzheimer's disease (AD), and there is evidence that tracking a person's eye movement, using eye tracking devices, can be used for the automatic identification of early signs of cognitive decline. However,…

Computation and Language · Computer Science 2019-10-02 Bahman Mirheidari , Yilin Pan , Traci Walker , Markus Reuber , Annalena Venneri , Daniel Blackburn , Heidi Christensen

Dementia is a group of irreversible, chronic, and progressive neurodegenerative disorders resulting in impaired memory, communication, and thought processes. In recent years, clinical research advances in brain aging have focused on the…

Computation and Language · Computer Science 2021-02-25 Swati Padhee , Anurag Illendula , Megan Sadler , Valerie L. Shalin , Tanvi Banerjee , Krishnaprasad Thirunarayan , William L. Romine