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Open-source simulation tools play a crucial role for neuromorphic application engineers and hardware architects to investigate performance bottlenecks and explore design optimizations before committing to silicon. Reconfigurable…

Emerging Technologies · Computer Science 2024-04-26 Sahil Hassan , Michael Inouye , Miguel C. Gonzalez , Ilkin Aliyev , Joshua Mack , Maisha Hafiz , Ali Akoglu

Here, we present the Digital Brain (DB), a platform for simulating spiking neuronal networks at the large neuron scale of the human brain based on personalized magnetic-resonance-imaging data and biological constraints. The DB aims to…

Neurons and Cognition · Quantitative Biology 2024-10-25 Wenlian Lu , Xin Du , Jiexiang Wang , Longbin Zeng , Leijun Ye , Shitong Xiang , Qibao Zheng , Jie Zhang , Ningsheng Xu , Jianfeng Feng

Big science initiatives are trying to reconstruct and model the brain by attempting to simulate brain tissue at larger scales and with increasingly more biological detail than previously thought possible. The exponential growth of parallel…

Performance · Computer Science 2020-06-25 Francesco Cremonesi , Georg Hager , Gerhard Wellein , Felix Schürmann

Much of studies on neural computation are based on network models of static neurons that produce analog output, despite the fact that information processing in the brain is predominantly carried out by dynamic neurons that produce discrete…

Neurons and Cognition · Quantitative Biology 2017-06-21 Dongsung Huh , Terrence J. Sejnowski

There has been a strong push recently to examine biological scale simulations of neuromorphic algorithms to achieve stronger inference capabilities. This paper presents a set of piecewise linear spiking neuron models, which can reproduce…

Machine Learning · Computer Science 2012-12-18 Hamid Soleimani , Arash Ahmadi , Mohammad Bavandpour

Spiking neural networks (SNNs) are a promising candidate for biologically-inspired and energy efficient computation. However, their simulation is notoriously time consuming, and may be seen as a bottleneck in developing competitive training…

Neural and Evolutionary Computing · Computer Science 2019-09-06 Daniel J. Saunders , Cooper Sigrist , Kenneth Chaney , Robert Kozma , Hava T. Siegelmann

Spiking neural network is a type of artificial neural network in which neurons communicate between each other with spikes. Spikes are identical Boolean events characterized by the time of their arrival. A spiking neuron has internal…

Neural and Evolutionary Computing · Computer Science 2016-02-16 Oleg Y. Sinyavskiy

Cortical synapse organization supports a range of dynamic states on multiple spatial and temporal scales, from synchronous slow wave activity (SWA), characteristic of deep sleep or anesthesia, to fluctuating, asynchronous activity during…

Neural and Evolutionary Computing · Computer Science 2019-11-27 Elena Pastorelli , Cristiano Capone , Francesco Simula , Maria V. Sanchez-Vives , Paolo Del Giudice , Maurizio Mattia , Pier Stanislao Paolucci

Spiking Neural Networks (SNNs) hold great potential to realize brain-inspired, energy-efficient computational systems. However, current SNNs still fall short in terms of multi-scale temporal processing compared to their biological…

Neural and Evolutionary Computing · Computer Science 2024-08-28 Xinyi Chen , Jibin Wu , Chenxiang Ma , Yinsong Yan , Yujie Wu , Kay Chen Tan

Simulation is a third pillar next to experiment and theory in the study of complex dynamic systems such as biological neural networks. Contemporary brain-scale networks correspond to directed graphs of a few million nodes, each with an…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-08-03 Jari Pronold , Jakob Jordan , Brian J. N. Wylie , Itaru Kitayama , Markus Diesmann , Susanne Kunkel

We present a SNN simulator which scales to millions of neurons, billions of synapses, and 8 GPUs. This is made possible by 1) a novel, cache-aware spike transmission algorithm 2) a model parallel multi-GPU distribution scheme and 3) a…

Neural and Evolutionary Computing · Computer Science 2021-09-23 Dennis Bautembach , Iason Oikonomidis , Antonis Argyros

As recurrent neural networks become larger and deeper, training times for single networks are rising into weeks or even months. As such there is a significant incentive to improve the performance and scalability of these networks. While…

Machine Learning · Computer Science 2016-04-08 Jeremy Appleyard , Tomas Kocisky , Phil Blunsom

Artificial Intelligence has looked into biological systems as a source of inspiration. Although there are many aspects of the brain yet to be discovered, neuroscience has found evidence that the connections between neurons continuously grow…

Neural and Evolutionary Computing · Computer Science 2020-10-29 Javier Lopez Randulfe , Leon Bonde Larsen

Cortical neurons include many sub-cellular processes, operating at multiple timescales, which may affect their response to stimulation through non-linear and stochastic interaction with ion channels and ionic concentrations. Since new…

Neurons and Cognition · Quantitative Biology 2014-05-01 Daniel Soudry , Ron Meir

Spiking Neural Networks (SNNs) are distinguished from Artificial Neural Networks (ANNs) for their complex neuronal dynamics and sparse binary activations (spikes) inspired by the biological neural system. Traditional neuron models use…

Neural and Evolutionary Computing · Computer Science 2025-10-31 Peng Xue , Wei Fang , Zhengyu Ma , Zihan Huang , Zhaokun Zhou , Yonghong Tian , Timothée Masquelier , Huihui Zhou

Computational neuroscience is being revolutionized with the advent of multi-electrode arrays that provide real-time, dynamic, perspectives into brain function. Mining event streams from these chips is critical to understanding the firing…

Distributed, Parallel, and Cluster Computing · Computer Science 2009-05-15 Yong Cao , Debprakash Patnaik , Sean Ponce , Jeremy Archuleta , Patrick Butler , Wu-chun Feng , Naren Ramakrishnan

Spiking neural networks (SNNs), central to computational neuroscience and neuromorphic machine learning (ML), require efficient simulation and gradient-based training. While AI accelerators offer promising speedups, gradient-based SNNs…

Neural and Evolutionary Computing · Computer Science 2025-12-08 Lennart P. L. Landsmeer , Amirreza Movahedin , Said Hamdioui , Christos Strydis

The complex regulatory dynamics of a biological network can be succinctly captured using discrete logic models. Given even sparse time-course data from the system of interest, previous work has shown that global optimization schemes are…

Molecular Networks · Quantitative Biology 2026-04-22 Joyce Reimer , Pranta Saha , Chris Chen , Neeraj Dhar , Brook Byrns , Steven Rayan , Gordon Broderick

Full scale simulations of neuronal network models of the brain are challenging due to the high density of connections between neurons. This contribution reports run times shorter than the simulated span of biological time for a full scale…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-10-04 Anno C. Kurth , Johanna Senk , Dennis Terhorst , Justin Finnerty , Markus Diesmann

Spiking neural networks (SNNs) recently gained momentum due to their low-power multiplication-free computing and the closer resemblance of biological processes in the nervous system of humans. However, SNNs require very long spike trains…

Hardware Architecture · Computer Science 2022-06-07 Daniel Gerlinghoff , Zhehui Wang , Xiaozhe Gu , Rick Siow Mong Goh , Tao Luo