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Understanding how stochastic gene expression is regulated in biological systems using snapshots of single-cell transcripts requires state-of-the-art methods of computational analysis and statistical inference. A Bayesian approach to…

Quantitative Methods · Quantitative Biology 2018-12-10 Yen Ting Lin , Nicolas E. Buchler

We consider learning problems of an intuitive and concise preference model, called lexicographic preference lists (LP-lists). Given a set of examples that are pairwise ordinal preferences over a universe of objects built of attributes of…

Artificial Intelligence · Computer Science 2019-09-20 Ahmed Moussa , Xudong Liu

Protein structure prediction can be shown to be an NP-hard problem; the number of conformations grows exponentially with the number of residues. The native conformations of proteins occupy a very small subset of these, hence an exploratory,…

Chemical Physics · Physics 2008-02-03 Mehul M. Khimasia , Peter V. Coveney

Symbolic regression is a machine learning technique, and it has seen many advancements in recent years, especially in genetic programming approaches (GPSR). Furthermore, it has been known for many years that constant optimization of…

Machine Learning · Computer Science 2024-12-04 L. G. A dos Reis , V. L. P. S. Caminha , T. J. P. Penna

This paper explores the use of genetic algorithms for the design of networks, where the demands on the network fluctuate in time. For varying network constraints, we find the best network using the standard genetic algorithm operators such…

Neural and Evolutionary Computing · Computer Science 2009-11-10 Matthew J. Berryman , Andrew Allison , Derek Abbott

Industrial robots are designed as general-purpose hardware with limited ability to adapt to changing task requirements or environments. Modular robots, on the other hand, offer flexibility and can be easily customized to suit diverse needs.…

Robotics · Computer Science 2024-03-05 Jonathan Külz , Matthias Althoff

Genetic algorithms are highly effective optimization techniques for many computationally challenging problems, including combinatorial optimization tasks like portfolio optimization. Quantum computing has also shown potential in addressing…

Emerging Technologies · Computer Science 2025-04-28 Mohammad Kashfi Haghighi , Matthieu Fortin-Deschênes , Christophe Pere , Mickaël Camus

This paper introduces Gene-Machine, an efficient and new search heuristic algorithm, based in the building-block hypothesis. It is inspired by natural evolution, but does not use some of the concepts present in genetic algorithms like…

Neural and Evolutionary Computing · Computer Science 2015-03-13 Alfredo Garcia Woods

A large number of application problems involve two levels of optimization, where one optimization task is nested inside the other. These problems are known as bilevel optimization problems and have been studied by both classical…

Optimization and Control · Mathematics 2017-05-09 Ankur Sinha , Zhichao Lu , Kalyanmoy Deb , Pekka Malo

In this paper, we study the influence of the selective pressure on the performance of cellular genetic algorithms. Cellular genetic algorithms are genetic algorithms where the population is embedded on a toroidal grid. This structure makes…

Artificial Intelligence · Computer Science 2008-12-18 David Simoncini , Philippe Collard , Sébastien Verel , Manuel Clergue

A new technique of global optimization and its applications in particular to neural networks are presented. The algorithm is also compared to other global optimization algorithms such as Gradient descent (GD), Monte Carlo (MC), Genetic…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-12-18 Homayoun Valafar , Okan K. Ersoy , Faramarz Valafar

Here we propose an evolutionary algorithm that self modifies its operators at the same time that candidate solutions are evolved. This tackles convergence and lack of diversity issues, leading to better solutions. Operators are represented…

Neural and Evolutionary Computing · Computer Science 2017-12-19 Andres Felipe Cruz Salinas , Jonatan Gomez Perdomo

This paper proposes Genetic Algorithm with Border Trades (GAB), a novel modification of the standard genetic algorithm that enhances exploration by incorporating new chromosome patterns in the breeding process. This approach significantly…

Machine Learning · Computer Science 2025-06-27 Qingchuan Lyu

Genetic algorithms are high-level heuristic optimization methods which enjoy great popularity thanks to their intuitive description, flexibility, and, of course, effectiveness. The optimization procedure is based on the evolution of…

Probability · Mathematics 2026-03-27 Giacomo Borghi

Gradient boosting is a state-of-the-art prediction technique that sequentially produces a model in the form of linear combinations of simple predictors---typically decision trees---by solving an infinite-dimensional convex optimization…

Statistics Theory · Mathematics 2017-07-18 Gérard Biau , Benoît Cadre

The primary aim of automated performance improvement is to reduce the running time of programs while maintaining (or improving on) functionality. In this paper, Genetic Programming is used to find performance improvements in regular…

Neural and Evolutionary Computing · Computer Science 2017-04-14 Brendan Cody-Kenny , Michael Fenton , Adrian Ronayne , Eoghan Considine , Thomas McGuire , Michael O'Neill

Genetic algorithms have unique properties which are useful when applied to black box optimization. Using selection, crossover, and mutation operators, candidate solutions may be obtained without the need to calculate a gradient. In this…

Quantum Physics · Physics 2022-06-23 David Von Dollen , Sheir Yarkoni , Daniel Weimer , Florian Neukart , Thomas Bäck

Optimization problem, nowadays, have more application in all major but they have problem in computation. Calculation of the optimum point in the spaces with the above dimensions is very time consuming. In this paper, there is presented a…

Neural and Evolutionary Computing · Computer Science 2013-07-24 Masoumeh Vali

The challenge of finding a global optimum in a solution search space with limited resources and higher accuracy has given rise to several optimization algorithms. Generally, the gradient-based optimizers converge to the global solution very…

Neural and Evolutionary Computing · Computer Science 2023-11-23 Subhrangshu Adhikary

We consider the optimization of an uncertain objective over continuous and multi-dimensional decision spaces in problems in which we are only provided with observational data. We propose a novel algorithmic framework that is tractable,…

Machine Learning · Statistics 2018-10-30 Dimitris Bertsimas , Christopher McCord
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