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In biological microscopy, light scattering represents the main limitation to image at depth. Recently, a set of wavefront shaping techniques has been developed in order to manipulate coherent light in strongly disordered materials. The…

Optics · Physics 2021-01-07 Antoine Boniface , Jonathan Dong , Sylvain Gigan

Holotomography (HT) has revolutionized quantitative label-free 3D imaging, yet conventional lens-based implementations are fundamentally constrained in field-of-view (FOV) and imaging depth, limiting their utility for critical…

Vision transformers have gained significant attention and achieved state-of-the-art performance in various computer vision tasks, including image classification, instance segmentation, and object detection. However, challenges remain in…

Computer Vision and Pattern Recognition · Computer Science 2023-11-21 Badri N. Patro , Vijay Srinivas Agneeswaran

Multiple light scattering hampers imaging objects in complex scattering media. Approaches used in real practices mainly aim to filter out multiple scattering obscuring the ballistic waves that travel straight through the scattering medium.…

We present a liquid crystal method of correcting the phase of an aberrated wavefront using a spatial light modulator. A simple and efficient lab model has been demonstrated for wavefront correction. The crux of a wavefront correcting system…

Instrumentation and Methods for Astrophysics · Physics 2009-10-11 Akondi Vyas , M. B. Roopashree , Ravinder Kumar Banyal , B. Raghavendra Prasad

Aberrations limit scanning fluorescence microscopy when imaging in scattering materials such as biological tissue. Model-based approaches for adaptive optics take advantage of a computational model of the optical setup. Such models can be…

Optics · Physics 2021-07-07 Ivan Vishniakou , Johannes D. Seelig

We present an imaging technique particularly suited to the detection of a target embedded in a strongly scattering medium. Classical imaging techniques based on the Born approximation fail in this kind of configuration because of multiply…

Classical Physics · Physics 2009-08-21 Alexandre Aubry , Arnaud Derode

Optical-resolution fluorescence imaging through and within complex samples presents a significant challenge due to random light scattering, with substantial implications across multiple fields. While significant advancements in coherent…

Optics · Physics 2023-12-27 Gil Weinberg , Elad Sunray , Ori Katz

Optical imaging through turbid or heterogeneous environments (collectively referred to as complex media) is fundamentally challenged by scattering, which scrambles structured spatial and phase information. To address this, we propose a…

Imaging inside scattering media at optical resolution is a longstanding challenge affecting multiple fields, from bio-medicine to astronomy. In recent years, several groundbreaking techniques for imaging inside scattering media, in…

Optics · Physics 2024-05-17 Elad Sunray , Gil Weinberg , Moriya Rosenfeld , Ori Katz

Complex Semi-Definite Programming (SDP) is introduced as a novel approach to phase retrieval enabled control of monochromatic light transmission through highly scattering media. In a simple optical setup, a spatial light modulator is used…

An ideal imaging system provides a spatial resolution that is ultimately dictated by the numerical aperture (NA) of the illumination and collection optics. In biological tissue, resolution is further affected by scattering limiting the…

Adaptive optics in combination with multi-photon techniques is a powerful approach to image deep into a specimen. Remarkably, virtually all adaptive optics schemes today rely on wavefront modulators which are reflective, diffractive, or…

Optical imaging through scattering media is a long-standing challenge. Although many approaches have been developed to focus light or image objects through scattering media, they are either invasive, restricted to stationary or…

Optics · Physics 2022-10-11 Xingchen Zhao , Xiaoyu Nie , Zhenhuan Yi , Tao Peng , Marlan O. Scully

The accurate segmentation of medical images is crucial for diagnosing and treating diseases. Recent studies demonstrate that vision transformer-based methods have significantly improved performance in medical image segmentation, primarily…

Computer Vision and Pattern Recognition · Computer Science 2024-05-22 Wentao Wang , Xi Xiao , Mingjie Liu , Qing Tian , Xuanyao Huang , Qizhen Lan , Swalpa Kumar Roy , Tianyang Wang

The goal of synthetic aperture imaging is to estimate the reflectivity of a remote region of interest by processing data gathered with a moving sensor which emits periodically a signal and records the backscattered wave. We introduce and…

Image and Video Processing · Electrical Eng. & Systems 2019-07-05 Liliana Borcea , Josselin Garnier

Three-photon (3P) microscopy is getting traction due to its superior performance in deep tissues. Yet, aberrations and light scattering still pose one of the main limitations in the attainable depth ranges for high-resolution imaging. Here,…

Deep-tissue optical imaging suffers from the reduction of resolving power due to tissue-induced optical aberrations and multiple scattering noise. Reflection matrix approaches recording the maps of backscattered waves for all the possible…

Adaptive optics can focus light through opaque media by compensating the random phase delay acquired while crossing a scattering curtain. The technique is commonly exploited in many fields, including astrophysics, microscopy, biomedicine…

Optics · Physics 2015-06-24 Diego Di Battista , Giannis Zacharakis , Marco Leonetti

Aberrations limit optical systems in many situations, for example when imaging in biological tissue. Machine learning offers novel ways to improve imaging under such conditions by learning inverse models of aberrations. Learning requires…

Optics · Physics 2021-04-30 Ivan Vishniakou , Johannes D. Seelig