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Related papers: Mol-Instructions: A Large-Scale Biomolecular Instr…

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Fine-tuning large language models (LLMs) on multi-task instruction-following data has been proven to be a powerful learning paradigm for improving their zero-shot capabilities on new tasks. Recent works about high-quality…

Computation and Language · Computer Science 2024-06-17 Wei Han , Hui Chen , Soujanya Poria

Large language models (LLMs) have substantially advanced machine learning research, including natural language processing, computer vision, data mining, etc., yet they still exhibit critical limitations in explainability, reliability,…

Machine Learning · Computer Science 2025-09-19 Xin Wang , Haoyang Li , Haibo Chen , Zeyang Zhang , Wenwu Zhu

In recent years, Large Language Models (LLMs) have achieved significant success in natural language processing (NLP) and various interdisciplinary areas. However, applying LLMs to chemistry is a complex task that requires specialized domain…

Machine Learning · Computer Science 2024-02-05 Chang Liao , Yemin Yu , Yu Mei , Ying Wei

Large language models (LLMs) have demonstrated impressive capabilities in various natural language processing tasks. Despite this, their application to information retrieval (IR) tasks is still challenging due to the infrequent occurrence…

Computation and Language · Computer Science 2024-05-29 Yutao Zhu , Peitian Zhang , Chenghao Zhang , Yifei Chen , Binyu Xie , Zheng Liu , Ji-Rong Wen , Zhicheng Dou

Recent advances in large language models (LLMs) have led to models that tackle diverse molecular tasks, such as chemical reaction prediction and molecular property prediction. Large-scale molecular instruction-tuning datasets have enabled…

Machine Learning · Computer Science 2025-05-27 Chanhui Lee , Hanbum Ko , Yuheon Song , YongJun Jeong , Rodrigo Hormazabal , Sehui Han , Kyunghoon Bae , Sungbin Lim , Sungwoong Kim

Multimodal large language models (MLLMs) have made impressive progress in many applications in recent years. However, chemical MLLMs that can handle cross-modal understanding and generation remain underexplored. To fill this gap, we propose…

Machine Learning · Computer Science 2025-08-05 Qian Tan , Dongzhan Zhou , Peng Xia , Wanhao Liu , Wanli Ouyang , Lei Bai , Yuqiang Li , Tianfan Fu

The emergence of Large Language Models (LLMs) has achieved tremendous success in the field of Natural Language Processing owing to diverse training paradigms that empower LLMs to effectively capture intricate linguistic patterns and…

Information Retrieval · Computer Science 2024-07-04 Lemei Zhang , Peng Liu , Yashar Deldjoo , Yong Zheng , Jon Atle Gulla

With the rapid advancements in large language model (LLM) technology and the emergence of bioinformatics-specific language models (BioLMs), there is a growing need for a comprehensive analysis of the current landscape, computational…

Molecule discovery is a pivotal research field, impacting everything from medicine to materials. Recently, Large Language Models (LLMs) have been widely adopted in molecular understanding and generation, serving as a bridge between the…

Computation and Language · Computer Science 2026-04-29 Jiatong Li , Yunqing Liu , Wei Liu , Jingdi Le , Di Zhang , Wenqi Fan , Dongzhan Zhou , Yuqiang Li , Qing Li

Large Language Models (LLMs) have made significant strides in natural language processing and are increasingly being integrated into recommendation systems. However, their potential in educational recommendation systems has yet to be fully…

Information Retrieval · Computer Science 2025-04-14 Boxuan Ma , Md Akib Zabed Khan , Tianyuan Yang , Agoritsa Polyzou , Shin'ichi Konomi

Rapid advancements in imaging techniques and analytical methods over the past decade have revolutionized our ability to comprehensively probe the biological world at multiple scales, pinpointing the type, quantity, location, and even…

Artificial Intelligence · Computer Science 2025-10-02 Shanghang Zhang , Gaole Dai , Tiejun Huang , Jianxu Chen

This paper introduces MM-Instruct, a large-scale dataset of diverse and high-quality visual instruction data designed to enhance the instruction-following capabilities of large multimodal models (LMMs). While existing visual instruction…

Computer Vision and Pattern Recognition · Computer Science 2024-07-01 Jihao Liu , Xin Huang , Jinliang Zheng , Boxiao Liu , Jia Wang , Osamu Yoshie , Yu Liu , Hongsheng Li

Large Language Models (LLMs) demonstrate strong performance in real-world applications, yet existing open-source instruction datasets often concentrate on narrow domains, such as mathematics or coding, limiting generalization and widening…

Computation and Language · Computer Science 2025-06-16 Jijie Li , Li Du , Hanyu Zhao , Bo-wen Zhang , Liangdong Wang , Boyan Gao , Guang Liu , Yonghua Lin

Large Language Models (LLMs) have shown promise in assisting scientific discovery. However, such applications are currently limited by LLMs' deficiencies in understanding intricate scientific concepts, deriving symbolic equations, and…

Computation and Language · Computer Science 2024-11-19 Dan Zhang , Ziniu Hu , Sining Zhoubian , Zhengxiao Du , Kaiyu Yang , Zihan Wang , Yisong Yue , Yuxiao Dong , Jie Tang

Large Language Models (LLMs) have shown impressive performance across various domains, but their ability to perform molecular reasoning remains underexplored. Existing methods mostly rely on general-purpose prompting, which lacks…

In recent years, instruction tuning has gained increasing attention and emerged as a crucial technique to enhance the capabilities of Large Language Models (LLMs). To construct high-quality instruction datasets, many instruction processing…

Computation and Language · Computer Science 2024-06-25 Yixin Ou , Ningyu Zhang , Honghao Gui , Ziwen Xu , Shuofei Qiao , Yida Xue , Runnan Fang , Kangwei Liu , Lei Li , Zhen Bi , Guozhou Zheng , Huajun Chen

Large language models (LLMs) can understand human instructions, showing their potential for pragmatic applications beyond traditional NLP tasks. However, they still struggle with complex instructions, which can be either complex task…

In biological tasks, data is rarely plentiful as it is generated from hard-to-gather measurements. Therefore, pre-training foundation models on large quantities of available data and then transfer to low-data downstream tasks is a promising…

Despite their ability to understand chemical knowledge, large language models (LLMs) remain limited in their capacity to propose novel molecules with desired functions (e.g., drug-like properties). In addition, the molecules that LLMs…

The ability of large language models (LLMs) to follow instructions is crucial to real-world applications. Despite recent advances, several studies have highlighted that LLMs struggle when faced with challenging instructions, especially…

Computation and Language · Computer Science 2024-04-04 Haoran Sun , Lixin Liu , Junjie Li , Fengyu Wang , Baohua Dong , Ran Lin , Ruohui Huang