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Objective: To develop a natural language processing (NLP) system to extract medications and contextual information that help understand drug changes. This project is part of the 2022 n2c2 challenge. Materials and methods: We developed NLP…

Computation and Language · Computer Science 2023-05-10 Aokun Chen , Zehao Yu , Xi Yang , Yi Guo , Jiang Bian , Yonghui Wu

Deep learning models have demonstrated superior performance in various healthcare applications. However, the major limitation of these deep models is usually the lack of high-quality training data due to the private and sensitive nature of…

Computation and Language · Computer Science 2022-11-15 Qiuhao Lu , Dejing Dou , Thien Huu Nguyen

The escalating volume of collected healthcare textual data presents a unique challenge for automated Multi-Label Text Classification (MLTC), which is primarily due to the scarcity of annotated texts for training and their nuanced nature.…

Computation and Language · Computer Science 2025-03-04 Hajar Sakai , Sarah S. Lam

The generative capabilities of LLM models offer opportunities for accelerating tasks but raise concerns about the authenticity of the knowledge they produce. To address these concerns, we present a computational approach that evaluates the…

Artificial Intelligence · Computer Science 2025-03-25 Ahmed Abdeen Hamed , Alessandro Crimi , Magdalena M. Misiak , Byung Suk Lee

Large language models (LLMs) have demonstrated powerful text generation capabilities, bringing unprecedented innovation to the healthcare field. While LLMs hold immense promise for applications in healthcare, applying them to real clinical…

Computation and Language · Computer Science 2023-10-16 Rui Yang , Edison Marrese-Taylor , Yuhe Ke , Lechao Cheng , Qingyu Chen , Irene Li

Electronic health records (EHRs) contain vast amounts of complex data, but harmonizing and processing this information remains a challenging and costly task requiring significant clinical expertise. While large language models (LLMs) have…

Computation and Language · Computer Science 2024-07-02 João Matos , Jack Gallifant , Jian Pei , A. Ian Wong

Objective: Clinical trials are essential for advancing pharmaceutical interventions, but they face a bottleneck in selecting eligible participants. Although leveraging electronic health records (EHR) for recruitment has gained popularity,…

Computation and Language · Computer Science 2026-01-15 Mojdeh Rahmanian , Seyed Mostafa Fakhrahmad , Seyedeh Zahra Mousavi

In this paper we study the problem of predicting clinical diagnoses from textual Electronic Health Records (EHR) data. We show the importance of this problem in medical community and present comprehensive historical review of the problem…

Computation and Language · Computer Science 2020-09-29 Pavel Blinov , Manvel Avetisian , Vladimir Kokh , Dmitry Umerenkov , Alexander Tuzhilin

Structured Electronic Health Record (EHR) data stores patient information in relational tables and plays a central role in clinical decision-making. Recent advances have explored the use of large language models (LLMs) to process such data,…

Artificial Intelligence · Computer Science 2026-04-02 Xiao Yang , Xuejiao Zhao , Zhiqi Shen

In support of open and reproducible research, there has been a rapidly increasing number of datasets made available for research. As the availability of datasets increases, it becomes more important to have quality metadata for discovering…

Computation and Language · Computer Science 2023-10-18 Shiwei Zhang , Mingfang Wu , Xiuzhen Zhang

Purpose: Enhanced health literacy has been linked to better health outcomes; however, few interventions have been studied. We investigate whether large language models (LLMs) can serve as a medium to improve health literacy in children and…

Computation and Language · Computer Science 2023-11-17 Kanhai S. Amin , Linda Mayes , Pavan Khosla , Rushabh Doshi

Electronic Health Records (EHRs) offer considerable potential for clinical prediction, but their complexity and heterogeneity challenge traditional machine learning. Domain-specific EHR foundation models trained on unlabeled EHR data have…

Large clinical datasets derived from insurance claims and electronic health record (EHR) systems are valuable sources for precision medicine research. These datasets can be used to develop models for personalized prediction of risk or…

Methodology · Statistics 2021-10-20 Liang Liang , Jue Hou , Hajime Uno , Kelly Cho , Yanyuan Ma , Tianxi Cai

The field of healthcare has increasingly turned its focus towards Large Language Models (LLMs) due to their remarkable performance. However, their performance in actual clinical applications has been underexplored. Traditional evaluations…

Applications of large language models (LLMs) like ChatGPT have potential to enhance clinical decision support through conversational interfaces. However, challenges of human-algorithmic interaction and clinician trust are poorly understood.…

Electronic health records (EHRs) are long, noisy, and often redundant, posing a major challenge for the clinicians who must navigate them. Large language models (LLMs) offer a promising solution for extracting and reasoning over this…

Computation and Language · Computer Science 2025-08-21 Skatje Myers , Dmitriy Dligach , Timothy A. Miller , Samantha Barr , Yanjun Gao , Matthew Churpek , Anoop Mayampurath , Majid Afshar

Background Large Language Models (LLMs), enhanced with Clinical Practice Guidelines (CPGs), can significantly improve Clinical Decision Support (CDS). However, methods for incorporating CPGs into LLMs are not well studied. Methods We…

Computation and Language · Computer Science 2024-01-25 David Oniani , Xizhi Wu , Shyam Visweswaran , Sumit Kapoor , Shravan Kooragayalu , Katelyn Polanska , Yanshan Wang

Rapid integration of large language models (LLMs) in health care is sparking global discussion about their potential to revolutionize health care quality and accessibility. At a time when improving health care quality and access remains a…

Computers and Society · Computer Science 2025-04-01 Troy Zada , Natalie Tam , Francois Barnard , Marlize Van Sittert , Venkat Bhat , Sirisha Rambhatla

ChatGPT has drawn considerable attention from both the general public and domain experts with its remarkable text generation capabilities. This has subsequently led to the emergence of diverse applications in the field of biomedicine and…

With the increasing application of large language models (LLMs) in the medical domain, evaluating these models' performance using benchmark datasets has become crucial. This paper presents a comprehensive survey of various benchmark…