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Surrogate markers are often employed in clinical trials to replace primary outcomes that may be difficult, expensive, or time-consuming to measure directly. These markers can accelerate the evaluation of new treatments, provided they…

Methodology · Statistics 2026-03-17 Pietro Carlotti , Layla Parast

This paper presents a Bayesian method for identification of jump Markov linear system parameters. A primary motivation is to provide accurate quantification of parameter uncertainty without relying on asymptotic in data-length arguments. To…

Methodology · Statistics 2021-02-11 Mark P. Balenzuela , Adrian G. Wills , Christopher Renton , Brett Ninness

Biomarker measurements can be relatively easy and quick to obtain and they are useful to investigate whether a compound works as intended on a mechanistic, pharmacological level. In some situations, it is realistic to assume that patients,…

Methodology · Statistics 2018-06-26 Björn Bornkamp , Georgina Bermann

The simultaneous estimation of multiple unknown parameters lies at heart of a broad class of important problems across science and technology. Currently, the state-of-the-art performance in the such problems is achieved by nonparametric…

Statistics Theory · Mathematics 2023-05-30 Alton Barbehenn , Sihai Dave Zhao

We study methods for simultaneous analysis of many noisy and biased estimates, each paired with an even noisier estimate of its own bias. The analyst's goal is to construct short calibrated intervals for each parameter. The standard…

Methodology · Statistics 2026-05-11 Wanyi Ling , Sida Li , Junming Guan , Nikolaos Ignatiadis

In this work, we delve into the nonparametric empirical Bayes theory and approximate the classical Bayes estimator by a truncation of the generalized Laguerre series and then estimate its coefficients by minimizing the prior risk of the…

Statistics Theory · Mathematics 2021-12-17 Rida Benhaddou , Matthew Connell

We consider an empirical likelihood inference for parameters defined by general estimating equations when some components of the random observations are subject to missingness. As the nature of the estimating equations is wide-ranging, we…

Statistics Theory · Mathematics 2009-03-05 Dong Wang , Song Xi Chen

The presence of interference renders classic Fisher randomization tests infeasible due to nuisance unknowns. To address this issue, we propose imputing the nuisance unknowns and computing Fisher randomization p-values multiple times, then…

Methodology · Statistics 2024-11-14 Tingxuan Han , Ke Zhu , Hanzhong Liu , Ke Deng

A common task in high-throughput biology is to screen for associations across thousands of units of interest, e.g., genes or proteins. Often, the data for each unit are modeled as Gaussian measurements with unknown mean and variance and are…

Statistics Theory · Mathematics 2024-10-01 Nikolaos Ignatiadis , Bodhisattva Sen

Parametric empirical Bayes (EB) estimators have been widely used in variety of fields including small area estimation, disease mapping. Since EB estimator is constructed by plugging in the estimator of parameters in prior distributions, it…

Methodology · Statistics 2017-04-28 Shonosuke Sugasawa

Statistical inference based on lossy or incomplete samples is often needed in research areas such as signal/image processing, medical image storage, remote sensing, signal transmission. In this paper, we propose a nonparametric testing…

Statistics Theory · Mathematics 2023-08-14 Kexuan Li , Ruiqi Liu , Ganggang Xu , Zuofeng Shang

We consider discrete nonparametric priors which induce Gibbs-type exchangeable random partitions and investigate their posterior behavior in detail. In particular, we deduce conditional distributions and the corresponding Bayesian…

Probability · Mathematics 2008-08-22 Antonio Lijoi , Igor Prünster , Stephen G. Walker

Statistical inference with nonresponse is quite challenging, especially when the response mechanism is nonignorable. In this case, the validity of statistical inference depends on untestable correct specification of the response model. To…

Methodology · Statistics 2021-01-15 Shonosuke Sugasawa , Kosuke Morikawa , Keisuke Takahata

Imputation is a popular approach to handling censored, missing, and error-prone covariates -- all coarsened data types for which the true values are unknown. However, there are nuances to imputing these different data types based on the…

Methodology · Statistics 2025-04-29 Sarah C. Lotspeich , Ethan M. Alt

Inference problems with incomplete observations often aim at estimating population properties of unobserved quantities. One simple way to accomplish this estimation is to impute the unobserved quantities of interest at the individual level…

Methodology · Statistics 2012-10-16 Vladimir N. Minin , John D. O'Brien , Arseni Seregin

Implicit sampling is a weighted sampling method that is used in data assimilation, where one sequentially updates estimates of the state of a stochastic model based on a stream of noisy or incomplete data. Here we describe how to use…

Numerical Analysis · Mathematics 2016-01-20 Matthias Morzfeld , Xuemin Tu , Jon Wilkening , Alexandre J. Chorin

Quantitative measurements produced by mass spectrometry proteomics experiments offer a direct way to explore the role of proteins in molecular mechanisms. However, analysis of such data is challenging due to the large proportion of missing…

Methodology · Statistics 2025-01-22 Haeun Moon , Jin-Hong Du , Jing Lei , Kathryn Roeder

Spurred on by recent successes in causal inference competitions, Bayesian nonparametric (and high-dimensional) methods have recently seen increased attention in the causal inference literature. In this paper, we present a comprehensive…

Methodology · Statistics 2022-01-11 Antonio R. Linero , Joseph L. Antonelli

This paper investigates the {\em nonasymptotic} properties of Bayes procedures for estimating an unknown distribution from $n$ i.i.d.\ observations. We assume that the prior is supported by a model $(\scr{S},h)$ (where $h$ denotes the…

Statistics Theory · Mathematics 2014-11-03 Lucien Birgé

We revisit empirical Bayes discrimination detection, focusing on uncertainty arising from both partial identification and sampling variability. While prior work has mostly focused on partial identification, we find that some empirical…

Econometrics · Economics 2025-08-19 Jiaying Gu , Nikolaos Ignatiadis , Azeem M. Shaikh