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The goal of these lecture notes is to review the problem of free energy minimization as a unified framework underlying the definition of maximum entropy modelling, generalized Bayesian inference, learning with latent variables, statistical…

Signal Processing · Electrical Eng. & Systems 2020-12-01 Sharu Theresa Jose , Osvaldo Simeone

We introduce the Free Energy Manifold (FEM), a score-trained conditional energy model specialized for inference in hybrid Bayesian networks with discrete and continuous variables. FEM represents each conditional factor as an energy…

Machine Learning · Computer Science 2026-05-12 Cheol Young Park , Shou Matsumoto

Based on a generative model (GM) and beliefs over hidden states, the free energy principle (FEP) enables an agent to sense and act by minimizing a free energy bound on Bayesian surprise. Inclusion of prior beliefs in the GM about desired…

Systems and Control · Electrical Eng. & Systems 2021-07-28 Thijs van de Laar , Ayça Özçelikkale , Henk Wymeersch

The Free Energy Principle (FEP) states that self-organizing systems must minimize variational free energy to persist, but the path from principle to implementable algorithm has remained unclear. We present a constructive proof that the FEP…

Neural and Evolutionary Computing · Computer Science 2025-10-22 Michael James McCulloch

The Free Energy Principle (FEP) is a theoretical framework for describing how (intelligent) systems self-organise into coherent, stable structures by minimising a free energy functional. Active Inference (AIF) is a corollary of the FEP that…

Artificial Intelligence · Computer Science 2023-10-17 Magnus Koudahl , Thijs van de Laar , Bert de Vries

Maximum entropy principle (MEP) offers an effective and unbiased approach to inferring unknown probability distributions when faced with incomplete information, while neural networks provide the flexibility to learn complex distributions…

Machine Learning · Statistics 2024-12-04 Wuyue Yang , Liangrong Peng , Guojie Li , Liu Hong

Free energy perturbation (FEP) is frequently used to evaluate the free energy change of a biological process, e.g. the drug binding free energy or the ligand solvation free energy. Due to the sampling inefficiency, FEP is often employed…

Chemical Physics · Physics 2017-01-31 Ying-Chih Chiang , Frank Otto

Transformers have emerged as the state of the art neural network architecture for natural language processing and computer vision. In the foundation model paradigm, large transformer models (BERT, GPT3/4, Bloom, ViT) are pre-trained on…

Machine Learning · Computer Science 2023-09-06 Guruprasad Raghavan , Bahey Tharwat , Surya Narayanan Hari , Dhruvil Satani , Matt Thomson

Bayesian model reduction provides an efficient approach for comparing the performance of all nested sub-models of a model, without re-evaluating any of these sub-models. Until now, Bayesian model reduction has been applied mainly in the…

Machine Learning · Computer Science 2024-10-15 Jim Beckers , Bart van Erp , Ziyue Zhao , Kirill Kondrashov , Bert de Vries

The efficient frontier (EF) is a fundamental resource allocation problem where one has to find an optimal portfolio maximizing a reward at a given level of risk. This optimal solution is traditionally found by solving a convex optimization…

Machine Learning · Computer Science 2023-10-17 Philippe Chatigny , Ivan Sergienko , Ryan Ferguson , Jordan Weir , Maxime Bergeron

This work proposes a hybrid modeling framework based on recurrent neural networks (RNNs) and the finite element (FE) method to approximate model discrepancies in time dependent, multi-fidelity problems, and use the trained hybrid models to…

Computational Engineering, Finance, and Science · Computer Science 2024-02-20 Moritz von Tresckow , Herbert De Gersem , Dimitrios Loukrezis

This work presents a machine learning approach to optimize the energy efficiency (EE) in a multi-cell wireless network. This optimization problem is non-convex and its global optimum is difficult to find. In the literature, either simple…

Signal Processing · Electrical Eng. & Systems 2023-12-18 Bile Peng , Karl-Ludwig Besser , Ramprasad Raghunath , Eduard A. Jorswieck

The Free Energy Principle (FEP) postulates that biological agents perceive and interact with their environment in order to minimize a Variational Free Energy (VFE) with respect to a generative model of their environment. The inference of a…

Machine Learning · Statistics 2022-04-07 Thijs van de Laar , Magnus Koudahl , Bart van Erp , Bert de Vries

We address the problem of planning under uncertainty, where an agent must choose actions that not only achieve desired outcomes but also reduce uncertainty. Traditional methods often treat exploration and exploitation as separate…

Coupled multiphysics simulations for high-dimensional, large-scale problems can be prohibitively expensive due to their computational demands. This article presents a novel framework integrating a deep operator network (DeepONet) with the…

Computational Engineering, Finance, and Science · Computer Science 2025-09-03 Fouad M. Amin , Diab W. Abueidda , Panos Pantidis , Mostafa E. Mobasher

The free energy principle, and its corollary active inference, constitute a bio-inspired theory that assumes biological agents act to remain in a restricted set of preferred states of the world, i.e., they minimize their free energy. Under…

Machine Learning · Computer Science 2022-07-15 Pietro Mazzaglia , Tim Verbelen , Ozan Çatal , Bart Dhoedt

We consider physics-informed neural networks (PINNs) [Raissi et al., J.~Comput. Phys. 278 (2019) 686-707] for forward physical problems. In order to find optimal PINNs configuration, we introduce a hyper-parameter optimization (HPO)…

Numerical Analysis · Mathematics 2023-02-01 Paul Escapil-Inchauspé , Gonzalo A. Ruz

The Expectation Maximization (EM) algorithm is the default algorithm for inference in latent variable models. As in any other field of machine learning, applications of latent variable models to very large datasets make the use of advanced…

Optimization and Control · Mathematics 2021-11-11 Aymeric Dieuleveut , Gersende Fort , Eric Moulines , Geneviève Robin

A vast majority of the current research in the field of Machine Learning is done using algorithms with strong arguments pointing to their biological implausibility such as Backpropagation, deviating the field's focus from understanding its…

Machine Learning · Computer Science 2022-10-27 Jose Miguel Ramos , Luis Sa-Couto , Andreas Wichert

The findable, accessible, interoperable, and reusable (FAIR) data principles provide a framework for examining, evaluating, and improving how data is shared to facilitate scientific discovery. Generalizing these principles to research…