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Photoacoustic imaging (PAI) represents an innovative biomedical imaging modality that harnesses the advantages of optical resolution and acoustic penetration depth while ensuring enhanced safety. Despite its promising potential across a…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Lei Wang , Weiming Zeng , Kai Long , Hongyu Chen , Rongfeng Lan , Li Liu , Wai Ting Siok , Nizhuan Wang

Photoacoustic imaging (PAI) is a promising approach to realize in vivo transcranial cerebral vascular imaging. However, the strong attenuation and distortion of the photoacoustic wave caused by the thick porous skull greatly affect the…

Medical Physics · Physics 2022-08-16 Ya Gao , Wenyi Xu , Yiming Chen , Weiya Xie , Qian Cheng

Photoacoustic imaging (PAI) is a promising emerging imaging modality that enables spatially resolved imaging of optical tissue properties up to several centimeters deep in tissue, creating the potential for numerous exciting clinical…

Medical Physics · Physics 2021-04-15 Janek Gröhl , Melanie Schellenberg , Kris Dreher , Lena Maier-Hein

Photoacoustic imaging (PAI) is a powerful imaging modality that relies on the PA effect. PAI works on the principle of electromagnetic energy absorption by the exogenous contrast agents and/or endogenous molecules present in the biological…

Optics · Physics 2020-12-16 Mohsin Zafar , Qiuyun Xu , Rayyan Manwar

Photoacoustic tomography (PAT) is a newly developed medical imaging modality, which combines the advantages of pure optical imaging and ultrasound imaging, owning both high optical contrast and deep penetration depth. Very recently, PAT is…

Medical Physics · Physics 2021-09-21 Tengbo Lyu , Jiadong Zhang , Zijian Gao , Changchun Yang , Feng Gao , Fei Gao

Real-time monitoring of functional tissue parameters, such as local blood oxygenation, based on optical imaging could provide groundbreaking advances in the diagnosis and interventional therapy of various diseases. While photoacoustic (PA)…

Medical Physics · Physics 2018-08-15 Thomas Kirchner , Janek Gröhl , Lena Maier-Hein

Significance: Photoacoustic imaging (PAI) promises to measure spatially-resolved blood oxygen saturation, but suffers from a lack of accurate and robust spectral unmixing methods to deliver on this promise. Accurate blood oxygenation…

One primary technical challenge in photoacoustic microscopy (PAM) is the necessary compromise between spatial resolution and imaging speed. In this study, we propose a novel application of deep learning principles to reconstruct…

Image and Video Processing · Electrical Eng. & Systems 2020-06-02 Anthony DiSpirito , Daiwei Li , Tri Vu , Maomao Chen , Dong Zhang , Jianwen Luo , Roarke Horstmeyer , Junjie Yao

Photoacoustic tomography (PAT) has the potential to recover morphological and functional tissue properties with high spatial resolution. However, previous attempts to solve the optical inverse problem with supervised machine learning were…

Image and Video Processing · Electrical Eng. & Systems 2022-10-26 Melanie Schellenberg , Janek Gröhl , Kris K. Dreher , Jan-Hinrich Nölke , Niklas Holzwarth , Minu D. Tizabi , Alexander Seitel , Lena Maier-Hein

Photoacoustic imaging (PAI) is a non-invasive imaging modality that detects the ultrasound signal generated from tissue with light excitation. Photoacoustic computed tomography (PACT) uses unfocused large-area light to illuminate the target…

Image and Video Processing · Electrical Eng. & Systems 2022-04-13 Hengrong Lan , Jiali Gong , Fei Gao

Multispectral photoacoustic imaging (PAI) is an emerging imaging modality which enables the recovery of functional tissue parameters such as blood oxygenation. However, the underlying inverse problems are potentially ill-posed, meaning that…

Photoacoustic tomography (PAT) is intrinsically sensitive to blood oxygen saturation (sO2) in vivo. However, making accurate sO2 measurements without knowledge of tissue- and instrumentation-related correction factors is extremely…

Medical Physics · Physics 2019-12-17 Marcel Gehrung , Sarah Bohndiek , Joanna Brunker

Background: Photoacoustic Microscopy (PAM) integrates optical and acoustic imaging, offering enhanced penetration depth for detecting optical-absorbing components in tissues. Nonetheless, challenges arise in scanning large areas with high…

Medical Physics · Physics 2023-12-15 Irem Loc , Mehmet Burcin Unlu

Photoacoustic imaging (PAI) is an emerging non-invasive imaging modality combining the advantages of deep ultrasound penetration and high optical contrast. Image reconstruction is an essential topic in PAI, which is unfortunately an…

Image and Video Processing · Electrical Eng. & Systems 2019-08-06 Hengrong Lan , Daohuai Jiang , Changchun Yang , Fei Gao

Photoacoustic tomography leverages ultrasound's deep tissue penetration to retrieve optical absorption contrast well beyond the optical diffusion limit. Conventional photoacoustic systems rely on externally delivered light and are therefore…

Optics · Physics 2026-01-06 David C. Garrett , Lihong V. Wang

Quantitative photoacoustic computed tomography (qPACT) is a promising imaging modality for estimating physiological parameters such as blood oxygen saturation. However, developing robust qPACT reconstruction methods remains challenging due…

Medical Physics · Physics 2025-10-07 Refik Mert Cam , Seonyeong Park , Umberto Villa , Mark A. Anastasio

Deep-learning-based super-resolution photoacoustic angiography (PAA) is a powerful tool that restores blood vessel images from under-sampled images to facilitate disease diagnosis. Nonetheless, due to the scarcity of training samples, PAA…

Image and Video Processing · Electrical Eng. & Systems 2023-05-03 Yuanzheng Ma , Wangting Zhou , Rui Ma , Sihua Yang , Yansong Tang , Xun Guan

We present numerical simulations for modelling optoacoustic (OA) signals observed in PVA hydrogel tissue phantoms. We review the computational approach to model the underlying mechanisms, i.e. optical absorption of laser energy and acoustic…

Computational Physics · Physics 2017-02-27 O. Melchert , E. Blumenröther , M. Wollweber , B. Roth

Multiwavelength photoacoustic images encode information about a tissue's optical absorption distribution. This can be used to estimate its blood oxygen saturation distribution (sO2), an important physiological indicator of tissue health and…

Medical Physics · Physics 2023-05-09 Ciaran Bench , Ben T. Cox

Conventional photoacoustic imaging may suffer from the limited view and bandwidth of ultrasound transducers. A deep learning approach is proposed to handle these problems and is demonstrated both in simulations and in experiments on a…

Image and Video Processing · Electrical Eng. & Systems 2020-11-19 Guillaume Godefroy , Bastien Arnal , Emmanuel Bossy
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