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We put forward the idea of establishing a novel interdisciplinary field of research at the interface between quantum mechanics and proteomics. The new field, called quantum proteomics, is defined as the large-scale study of the electronic…

Biomolecules · Quantitative Biology 2011-08-01 Fabio Pichierri

Emergent behavior, which arises from local interactions between simple elements, is pervasive in nature. It underlies the energy-efficient computing in our brains. However, realizing such dynamics in artificial materials, particularly under…

Atoms are ideal quantum sensors and quantum light emitters. Interfacing atoms with nanophotonic devices promises novel nanoscale sensing and quantum optical functionalities. But precise optical control of atomic states in these devices is…

As the limits of traditional von Neumann computing come into view, the brain's ability to communicate vast quantities of information using low-power spikes has become an increasing source of inspiration for alternative architectures. Key to…

Neurons and Cognition · Quantitative Biology 2020-12-02 Emily Toomey , Ken Segall , Matteo Castellani , Marco Colangelo , Nancy Lynch , Karl K. Berggren

Cryo-electron microscopy (cryo-EM) emerges as a pivotal technology for determining the architecture of cells, viruses, and protein assemblies at near-atomic resolution. Traditional particle picking, a key step in cryo-EM, struggles with…

Biomolecules · Quantitative Biology 2024-04-17 Chentianye Xu , Xueying Zhan , Min Xu

Flow-Imaging Microscopy (FIM) is commonly used in both academia and industry to characterize subvisible particles (those $\le 25 \mu m$ in size) in protein therapeutics. Pharmaceutical companies are required to record vast volumes of FIM…

Quantitative Methods · Quantitative Biology 2017-09-04 Christopher P. Calderon , Austin L. Daniels , Theodore W. Randolph

A device capable of performing real time classification of proteins in a clinical setting would allow for inexpensive and rapid disease diagnosis. One such candidate for this technology are nanopore devices. These devices work by measuring…

Machine Learning · Computer Science 2025-09-18 Samuel Tovey , Julian Hoßbach , Sandro Kuppel , Tobias Ensslen , Jan C. Behrends , Christian Holm

The characteristics of the surface waves along the interface between a plasma and a dielectric material have been investigated using kinetic Particle-In-Cell (PIC) simulations. A microwave source of GHz frequency has been used to trigger…

Plasma Physics · Physics 2022-06-29 Rinku Mishra , Sayan Adhikari , Rupak Mukherjee , B. J. Saikia

The potential energy surface (PES) is crucial for interpreting a variety of chemical reaction processes. However, predicting accurate PESs with high-level electronic structure methods is a challenging task due to the high computational…

Chemical Physics · Physics 2022-06-09 Yanxian Tao , Xiongzhi Zeng , Yi Fan , Jie Liu , Zhenyu Li , Jinlong Yang

Fluid ferroelectrics, a recently discovered class of liquid crystals that exhibit switchable, long-range polar order, offer opportunities in ultrafast electro-optic technologies, responsive soft matter, and next-generation energy materials.…

Analyzing the structure of proteins is a key part of understanding their functions and thus their role in biology at the molecular level. In addition, design new proteins in a methodical way is a major engineering challenge. In this work,…

Computer Vision and Pattern Recognition · Computer Science 2021-06-23 Hao Huang , Boulbaba Ben Amor , Xichan Lin , Fan Zhu , Yi Fang

Control over molecular scale electrical properties within nano junctions is demonstrated, utilizing site-directed C60 targeting into protein macromolecules as a doping means. The protein molecules, self-assembled in a miniaturized…

Mesoscale and Nanoscale Physics · Physics 2011-12-13 Elad Mentovich , Bogdan Belgorodsky , Michael Gozin , Shachar Richter , Hagai Cohen

Dynamical nuclear polarisation (DNP) is an important technique that uses polarisation transfer from electron to nuclear spins to achieve nuclear hyperpolarisation. As the electron spin of the nitrogen vacancy (NV) centres in diamond can be…

It is demonstrated that the time evolution of the electron-nuclear polarization transfer process during pulsed dynamic nuclear polarization (DNP) can be reversed on a microsecond timescale, leading to the observation of DNP echoes. The DNP…

Chemical Physics · Physics 2024-06-28 Nino Wili , Anders B. Nielsen , José P. Carvalho , Niels Chr. Nielsen

We introduce a scheme for molecular simulations, the Deep Potential Molecular Dynamics (DeePMD) method, based on a many-body potential and interatomic forces generated by a carefully crafted deep neural network trained with ab initio data.…

Computational Physics · Physics 2018-04-11 Linfeng Zhang , Jiequn Han , Han Wang , Roberto Car , Weinan E

This work reports a nanostructure resonant tunnelling diode-photodetector (RTD-PD) device and demonstrates its operation as a controllable, optically-triggered excitable spike generator. The top contact layer of the device is designed with…

In this work, we introduce an optoelectronic spiking artificial neuron capable of operating at ultrafast rates ($\approx$ 100 ps/optical spike) and with low energy consumption ($<$ pJ/spike). The proposed system combines an excitable…

For decades, searches for exotic spin interactions have used increasingly-precise laboratory measurements to test various theoretical models of particle physics. However, most searches have focused on interaction length scales greater than…

Quantum Physics · Physics 2022-07-04 P. -H. Chu , N. Ristoff , J. Smits , N. Jackson , Y. J. Kim , I. Savukov , V. M. Acosta

DNA-interacting proteins have roles multiple processes, many operating as molecular machines which undergo dynamic metastable transitions to bring about their biological function. To fully understand this molecular heterogeneity, DNA and…

Biomolecules · Quantitative Biology 2015-04-15 Adam J. M. Wollman , Helen Miller , Zhaokun Zhou , Mark C. Leake

This work exploits the zeptoliter sensing volume of electrolyte-filled nanopores to determine, simultaneously and in real time, the approximate shape, volume, charge, rotational diffusion coefficient, and dipole moment of individual…