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To address the interpretability challenge in machine learning (ML) systems, counterfactual explanations (CEs) have emerged as a promising solution. CEs are unique as they provide workable suggestions to users, instead of explaining why a…

Artificial Intelligence · Computer Science 2026-02-03 Ming Wang , Daling Wang , Wenfang Wu , Shi Feng , Yifei Zhang

Counterfactual explanations (CEs) are advocated as being ideally suited to providing algorithmic recourse for subjects affected by the predictions of machine learning models. While CEs can be beneficial to affected individuals, recent work…

Machine Learning · Computer Science 2024-02-06 Junqi Jiang , Francesco Leofante , Antonio Rago , Francesca Toni

Counterfactual explanations aim to enhance model transparency by showing how inputs can be minimally altered to change predictions. For multivariate time series, existing methods often generate counterfactuals that are invalid, implausible,…

Machine Learning · Computer Science 2026-02-18 Sarah Seifi , Anass Ibrahimi , Tobias Sukianto , Cecilia Carbonelli , Lorenzo Servadei , Robert Wille

Post-hoc explanations of machine learning models are crucial for people to understand and act on algorithmic predictions. An intriguing class of explanations is through counterfactuals, hypothetical examples that show people how to obtain a…

Machine Learning · Computer Science 2019-12-09 Ramaravind Kommiya Mothilal , Amit Sharma , Chenhao Tan

This work presents CounterNet, a novel end-to-end learning framework which integrates Machine Learning (ML) model training and the generation of corresponding counterfactual (CF) explanations into a single end-to-end pipeline.…

Machine Learning · Computer Science 2023-06-23 Hangzhi Guo , Thanh Hong Nguyen , Amulya Yadav

Deep learning-based recommender systems have become an integral part of several online platforms. However, their black-box nature emphasizes the need for explainable artificial intelligence (XAI) approaches to provide human-understandable…

Information Retrieval · Computer Science 2023-05-02 Ziheng Chen , Fabrizio Silvestri , Jia Wang , Yongfeng Zhang , Gabriele Tolomei

Machine learning (ML) systems for medical imaging have demonstrated remarkable diagnostic capabilities, but their susceptibility to biases poses significant risks, since biases may negatively impact generalization performance. In this…

Machine Learning · Computer Science 2025-04-29 Haroui Ma , Francesco Quinzan , Theresa Willem , Stefan Bauer

As machine learning (ML)-based decision support tools proliferate in clinical practice, understanding how clinicians integrate personalized ML predictions alongside randomized controlled trial (RCT) evidence is critical. We designed a…

Human-Computer Interaction · Computer Science 2026-05-19 Zeshan Hussain , Barbara D. Lam , Fernando A. Acosta-Perez , Irbaz Bin Riaz , Maia Jacobs , Andrew J. Yee , David Sontag

This research addresses the challenge of conducting interpretable causal inference between a binary treatment and its resulting outcome when not all confounders are known. Confounders are factors that have an influence on both the treatment…

Machine Learning · Computer Science 2023-10-24 Sohaib Kiani , Jared Barton , Jon Sushinsky , Lynda Heimbach , Bo Luo

This paper considers the use of Machine Learning (ML) in medicine by focusing on the main problem that this computational approach has been aimed at solving or at least minimizing: uncertainty. To this aim, we point out how uncertainty is…

Machine Learning · Computer Science 2018-05-15 Federico Cabitza , Davide Ciucci , Raffaele Rasoini

Accurate and early prediction of a disease allows to plan and improve a patient's quality of future life. During pandemic situations, the medical decision becomes a speed challenge in which physicians have to act fast to diagnose and…

Machine Learning · Computer Science 2022-06-09 Pierluigi Costanzo , Kalia Orphanou

In high-stakes domains like medicine, it may be generally desirable for models to faithfully adhere to the context provided. But what happens if the context does not align with model priors or safety protocols? In this paper, we investigate…

Computation and Language · Computer Science 2026-04-21 Kaijie Mo , Siddhartha Venkatayogi , Chantal Shaib , Ramez Kouzy , Wei Xu , Byron C. Wallace , Junyi Jessy Li

We examine counterfactual explanations for explaining the decisions made by model-based AI systems. The counterfactual approach we consider defines an explanation as a set of the system's data inputs that causally drives the decision (i.e.,…

Machine Learning · Computer Science 2021-10-14 Carlos Fernández-Loría , Foster Provost , Xintian Han

Counterfactual (CF) explanations have been employed as one of the modes of explainability in explainable AI-both to increase the transparency of AI systems and to provide recourse. Cognitive science and psychology, however, have pointed out…

Artificial Intelligence · Computer Science 2022-12-14 Marko Tesic , Ulrike Hahn

Causal machine learning (CML) has experienced increasing popularity in healthcare. Beyond the inherent capabilities of adding domain knowledge into learning systems, CML provides a complete toolset for investigating how a system would react…

Machine Learning · Computer Science 2022-06-01 Pedro Sanchez , Jeremy P. Voisey , Tian Xia , Hannah I. Watson , Alison Q. ONeil , Sotirios A. Tsaftaris

Counterfactual explanations (CEs) enhance the interpretability of machine learning models by describing what changes to an input are necessary to change its prediction to a desired class. These explanations are commonly used to guide users'…

Machine Learning · Computer Science 2024-03-07 Anna P. Meyer , Yuhao Zhang , Aws Albarghouthi , Loris D'Antoni

Clinical practice in psychiatry is burdened with the increased demand for healthcare services and the scarce resources available. New paradigms of health data powered with machine learning techniques could open the possibility to improve…

Artificial Intelligence · Computer Science 2023-06-08 Juan Sebastian Canas , Francisco Gomez , Omar Costilla-Reyes

In medical time series disease diagnosis, two key challenges are identified.First, the high annotation cost of medical data leads to overfitting in models trained on label-limited, single-center datasets. To address this, we propose…

Machine Learning · Computer Science 2025-01-31 Yifan Wang , Hongfeng Ai , Ruiqi Li , Maowei Jiang , Cheng Jiang , Chenzhong Li

Counterfactual (CF) explanations, also known as contrastive explanations and algorithmic recourses, are popular for explaining machine learning models in high-stakes domains. For a subject that receives a negative model prediction (e.g.,…

Machine Learning · Computer Science 2023-06-20 Yilun Zhou

Background: This study investigates how variations in Major Depressive Disorder (MDD) symptoms, quantified by the Hamilton Rating Scale for Depression (HAM-D), causally influence the prescription of SSRIs versus SNRIs. Methods: We applied…

Artificial Intelligence · Computer Science 2025-08-26 Xinyu Qin , Mark H. Chignell , Alexandria Greifenberger , Sachinthya Lokuge , Elssa Toumeh , Tia Sternat , Martin Katzman , Lu Wang