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Related papers: Robust Brain Age Estimation via Regression Models …

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Numerous studies have established that estimated brain age, as derived from statistical models trained on healthy populations, constitutes a valuable biomarker that is predictive of cognitive decline and various neurological diseases. In…

Computer Vision and Pattern Recognition · Computer Science 2019-07-02 Xinyang Feng , Zachary C. Lipton , Jie Yang , Scott A. Small , Frank A. Provenzano

MRI-based brain age estimation models aim to assess a subject's biological brain age based on information, such as neuroanatomical features. Various factors, including neurodegenerative diseases, can accelerate brain aging and measuring…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Simon Joseph Clément Crête , Marta Kersten-Oertel , Yiming Xiao

Purpose: To develop an age prediction model which is interpretable and robust to demographic and technological variances in brain MRI scans. Materials and Methods: We propose a transformer-based architecture that leverages self-supervised…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Pengyu Kan , Craig Jones , Kenichi Oishi

The concept of biological age (BA), although important in clinical practice, is hard to grasp mainly due to the lack of a clearly defined reference standard. For specific applications, especially in pediatrics, medical image data are used…

Image and Video Processing · Electrical Eng. & Systems 2021-03-22 Karim Armanious , Sherif Abdulatif , Wenbin Shi , Shashank Salian , Thomas Küstner , Daniel Weiskopf , Tobias Hepp , Sergios Gatidis , Bin Yang

Brain age estimation from Magnetic Resonance Images (MRI) derives the difference between a subject's biological brain age and their chronological age. This is a potential biomarker for neurodegeneration, e.g. as part of Alzheimer's disease.…

Computer Vision and Pattern Recognition · Computer Science 2020-10-02 Kyriaki-Margarita Bintsi , Vasileios Baltatzis , Arinbjörn Kolbeinsson , Alexander Hammers , Daniel Rueckert

Accurate estimation of biological brain age from three dimensional (3D) T$_1$-weighted magnetic resonance imaging (MRI) is a critical imaging biomarker for identifying accelerated aging associated with neurodegenerative diseases. Effective…

Image and Video Processing · Electrical Eng. & Systems 2025-08-05 Mehreen Kanwal , Yunsik Son

Machine learning analysis of neuroimaging data can accurately predict chronological age in healthy people and deviations from healthy brain ageing have been associated with cognitive impairment and disease. Here we sought to further…

Age is an essential factor in modern diagnostic procedures. However, assessment of the true biological age (BA) remains a daunting task due to the lack of reference ground-truth labels. Current BA estimation approaches are either restricted…

Computer Vision and Pattern Recognition · Computer Science 2021-05-18 Karim Armanious , Sherif Abdulatif , Wenbin Shi , Tobias Hepp , Sergios Gatidis , Bin Yang

Brain aging involves structural and functional changes and therefore serves as a key biomarker for brain health. Combining structural magnetic resonance imaging (sMRI) and functional magnetic resonance imaging (fMRI) has the potential to…

Computer Vision and Pattern Recognition · Computer Science 2024-12-10 Abd Ur Rehman , Azka Rehman , Muhammad Usman , Abdullah Shahid , Sung-Min Gho , Aleum Lee , Tariq M. Khan , Imran Razzak

The accurate quantification of brain age from MRI has emerged as an important biomarker of brain health. However, existing approaches are often restricted to narrow age ranges and single-modality MRI data, limiting their capacity to capture…

Image and Video Processing · Electrical Eng. & Systems 2026-04-21 Dingyi Zhang , Ruiying Liu , Yun Wang

The human electroencephalogram (EEG) of sleep undergoes profound changes with age. These changes can be conceptualized as "brain age", which can be compared to an age norm to reflect the deviation from normal aging process. Here, we develop…

Chronological age of healthy people is able to be predicted accurately using deep neural networks from neuroimaging data, and the predicted brain age could serve as a biomarker for detecting aging-related diseases. In this paper, a novel 3D…

Image and Video Processing · Electrical Eng. & Systems 2021-06-08 Jian Cheng , Ziyang Liu , Hao Guan , Zhenzhou Wu , Haogang Zhu , Jiyang Jiang , Wei Wen , Dacheng Tao , Tao Liu

Brain age has become a prominent biomarker of brain health. Yet most prior work targets whole brain age (WBA), a coarse paradigm that struggles to support tasks such as disease characterization and research on development and aging…

Computer Vision and Pattern Recognition · Computer Science 2026-02-16 Shuai Shao , Yan Wang , Shu Jiang , Shiyuan Zhao , Xinzhe Luo , Di Yang , Jiangtao Wang , Yutong Bai , Jianguo Zhang

Brain Age (BA) estimation via Deep Learning has become a strong and reliable bio-marker for brain health, but the black-box nature of Neural Networks does not easily allow insight into the features of brain ageing.We trained a ResNet model…

Neurons and Cognition · Quantitative Biology 2022-07-26 Daniel Taylor , Jonathan Shock , Deshendran Moodley , Jonathan Ipser , Matthias Treder

Age prediction using brain imaging, such as MRIs, has achieved promising results, with several studies identifying the model's residual as a potential biomarker for chronic disease states. In this study, we developed a brain age predictive…

Machine Learning · Computer Science 2025-04-22 Shahrzad Jamshidi , Arthur Bousquet , Sugata Banerji , Mark F. Conneely , Bita Aslrousta

Age is an important variable to describe the expected brain's anatomy status across the normal aging trajectory. The deviation from that normative aging trajectory may provide some insights into neurological diseases. In neuroimaging,…

Computer Vision and Pattern Recognition · Computer Science 2023-04-14 Huy-Dung Nguyen , Michaël Clément , Boris Mansencal , Pierrick Coupé

Age is one of the major known risk factors for Alzheimer's Disease (AD). Detecting AD early is crucial for effective treatment and preventing irreversible brain damage. Brain age, a measure derived from brain imaging reflecting structural…

Image and Video Processing · Electrical Eng. & Systems 2024-05-07 Jay Shah , Md Mahfuzur Rahman Siddiquee , Yi Su , Teresa Wu , Baoxin Li

Important applications of advancements in machine learning, are in the area of healthcare, more so for neurological disorder detection. A crucial step towards understanding the neurological status, is to estimate the brain age using…

Image and Video Processing · Electrical Eng. & Systems 2024-07-10 Vamshi Krishna Kancharla , Neelam Sinha

Deep learning models have achieved state-of-the-art results in estimating brain age, which is an important brain health biomarker, from magnetic resonance (MR) images. However, most of these models only provide a global age prediction, and…

Image and Video Processing · Electrical Eng. & Systems 2023-08-25 Neha Gianchandani , Mahsa Dibaji , Mariana Bento , Ethan MacDonald , Roberto Souza
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