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PET is affected by statistical noise due to constraints on tracer dose and scan duration, impacting both diagnostic performance and quantitative accuracy. While deep learning (DL)-based PET denoising methods have been used to improve image…

Deep learning (DL) has arguably emerged as the method of choice for the detection and segmentation of biological structures in microscopy images. However, DL typically needs copious amounts of annotated training data that is for biomedical…

Image and Video Processing · Electrical Eng. & Systems 2020-03-20 Mangal Prakash , Tim-Oliver Buchholz , Manan Lalit , Pavel Tomancak , Florian Jug , Alexander Krull

Denoising low-dose computed tomography (CT) images is a critical task in medical image computing. Supervised deep learning-based approaches have made significant advancements in this area in recent years. However, these methods typically…

Image and Video Processing · Electrical Eng. & Systems 2023-07-17 Xuan Liu , Yaoqin Xie , Jun Cheng , Songhui Diao , Shan Tan , Xiaokun Liang

Magnetic particle imaging (MPI) is an in-vivo imaging method to detect magnetic nanoparticles for blood vessel imaging and molecular target imaging. Compared with conventional molecular imaging devices (such as nuclear medicine imaging PET…

Medical Physics · Physics 2024-04-26 Guang Jia , Zhongwei Bian , Tianshu Li , Shi Bai , Chenxing Hu , Lixuan Zhao , Peng Gao , Tanping Li , Hui Hui , Jie Tian

This study aimed to propose a denoising method for dynamic contrast-enhanced computed tomography (DCE-CT) perfusion studies using a three-dimensional deep image prior (DIP), and to investigate its usefulness in comparison with total…

Medical Physics · Physics 2023-04-04 Kenya Murase

Deep image prior (DIP) is an unsupervised deep learning framework that has been successfully applied to a variety of inverse imaging problems. However, DIP-based methods are inherently prone to overfitting, which leads to performance…

Computer Vision and Pattern Recognition · Computer Science 2026-04-10 Panagiotis Gkotsis , Athanasios A. Rontogiannis

With the development of deep learning, medical image processing has been widely used to assist clinical research. This paper focuses on the denoising problem of low-dose computed tomography using deep learning. Although low-dose computed…

Image and Video Processing · Electrical Eng. & Systems 2026-05-19 Zhilin Guan , Wei Zhang

Medical imaging aims to recover underlying tissue properties, using inexact (simplified/linearized) imaging models and often from inaccurate and incomplete measurements. Analytical reconstruction methods rely on hand-crafted regularization,…

Image and Video Processing · Electrical Eng. & Systems 2026-04-03 Can Deniz Bezek , Orcun Goksel

Ultrasound imaging is widely used in noninvasive medical diagnostics due to its efficiency, portability, and avoidance of ionizing radiation. However, its utility is limited by the quality of the signal. Signal-dependent speckle noise,…

Image and Video Processing · Electrical Eng. & Systems 2026-02-10 Soumee Guha , Scott T. Acton

We extend the blindspot model for self-supervised denoising to handle Poisson-Gaussian noise and introduce an improved training scheme that avoids hyperparameters and adapts the denoiser to the test data. Self-supervised models for…

Image and Video Processing · Electrical Eng. & Systems 2020-11-20 Wesley Khademi , Sonia Rao , Clare Minnerath , Guy Hagen , Jonathan Ventura

Low-dose CT images are essential for reducing radiation exposure in cancer screening, pediatric imaging, and longitudinal monitoring protocols, but their quality is often degraded by noise from low-dose acquisition, patient motion, or…

Computer Vision and Pattern Recognition · Computer Science 2026-03-12 Jitindra Fartiyal , Pedro Freire , Sergei K. Turitsyn , Sergei G. Solovski

Image denoising and high-level vision tasks are usually handled independently in the conventional practice of computer vision, and their connection is fragile. In this paper, we cope with the two jointly and explore the mutual influence…

Computer Vision and Pattern Recognition · Computer Science 2018-09-10 Ding Liu , Bihan Wen , Jianbo Jiao , Xianming Liu , Zhangyang Wang , Thomas S. Huang

This work proposes a learning-based statistical refinement method for improving the denoising results of a given denoiser without knowing the precise noise distribution or accessing clean images or calibration data. While there are many…

Machine Learning · Computer Science 2026-05-07 Rihuan Ke

Under certain statistical assumptions of noise, recent self-supervised approaches for denoising have been introduced to learn network parameters without true clean images, and these methods can restore an image by exploiting information…

Computer Vision and Pattern Recognition · Computer Science 2020-01-10 Seunghwan Lee , Donghyeon Cho , Jiwon Kim , Tae Hyun Kim

Since the development of self-supervised visual representation learning from contrastive learning to masked image modeling (MIM), there is no significant difference in essence, that is, how to design proper pretext tasks for vision…

Computer Vision and Pattern Recognition · Computer Science 2023-01-31 Kun Yi , Yixiao Ge , Xiaotong Li , Shusheng Yang , Dian Li , Jianping Wu , Ying Shan , Xiaohu Qie

Recent advances in diffusion models have spurred research into their application for Reconstruction-based unsupervised anomaly detection. However, these methods may struggle with maintaining structural integrity and recovering the…

Computer Vision and Pattern Recognition · Computer Science 2025-03-27 Farzad Beizaee , Gregory A. Lodygensky , Christian Desrosiers , Jose Dolz

Advances in microscopy imaging enable researchers to visualize structures at the nanoscale level thereby unraveling intricate details of biological organization. However, challenges such as image noise, photobleaching of fluorophores, and…

Image and Video Processing · Electrical Eng. & Systems 2024-09-19 Pamela Osuna-Vargas , Maren H. Wehrheim , Lucas Zinz , Johanna Rahm , Ashwin Balakrishnan , Alexandra Kaminer , Mike Heilemann , Matthias Kaschube

Performance of the sensor-based camera identification (SCI) method heavily relies on the denoising filter in estimating Photo-Response Non-Uniformity (PRNU). Given various attempts on enhancing the quality of the extracted PRNU, it still…

Image and Video Processing · Electrical Eng. & Systems 2021-12-07 Hui Zeng , Morteza Darvish Morshedi Hosseini , Kang Deng , Anjie Peng , Miroslav Goljan

Magnetic Resonance Imaging (MRI), including diffusion MRI (dMRI), serves as a ``microscope'' for anatomical structures and routinely mitigates the influence of low signal-to-noise ratio scans by compromising temporal or spatial resolution.…

Image and Video Processing · Electrical Eng. & Systems 2025-03-11 Chenxu Wu , Qingpeng Kong , Zihang Jiang , S. Kevin Zhou

Deconvolution is the most commonly used image processing method to remove the blur caused by the point-spread-function (PSF) in optical imaging systems. While this method has been successful in deblurring, it suffers from several…

Image and Video Processing · Electrical Eng. & Systems 2019-10-10 Huangxuan Zhao , Ziwen Ke , Ningbo Chen , Ke Li , Lidai Wang , Xiaojing Gong , Wei Zheng , Liang Song , Zhicheng Liu , Dong Liang , Chengbo Liu