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Multiplexed imaging allows multiple cell types to be simultaneously visualised in a single tissue sample, generating unprecedented amounts of spatially-resolved, biological data. In topological data analysis, persistent homology provides…

Quantitative Methods · Quantitative Biology 2025-05-06 Maria Torras-Pérez , Iris H. R. Yoon , Praveen Weeratunga , Ling-Pei Ho , Helen M. Byrne , Ulrike Tillmann , Heather A. Harrington

Persistent homology (PH) studies the topology of data across multiple scales by building nested collections of topological spaces called filtrations, computing homology and returning an algebraic object that can be vizualised as a…

Algebraic Topology · Mathematics 2024-11-14 David Beers , Heather A Harrington , Jacob Leygonie , Uzu Lim , Louis Theran

We propose a unified framework based on persistent homology (PH) to characterize both local and global structures in disordered systems. It can simultaneously generate local and global descriptors using the same algorithm and data…

Disordered Systems and Neural Networks · Physics 2025-11-03 An Wang , Li Zou

Including intricate topological information (e.g., cycles) provably enhances the expressivity of message-passing graph neural networks (GNNs) beyond the Weisfeiler-Leman (WL) hierarchy. Consequently, Persistent Homology (PH) methods are…

Machine Learning · Computer Science 2026-02-05 Mattie Ji , Amauri H. Souza , Vikas Garg

Persistent homology (PH) is a rigorous mathematical theory that provides a robust descriptor of data in the form of persistence diagrams (PDs). PDs exhibit, however, complex structure and are difficult to integrate in today's machine…

Machine Learning · Statistics 2019-06-11 Bartosz Zieliński , Michał Lipiński , Mateusz Juda , Matthias Zeppelzauer , Paweł Dłotko

Topological Data Analysis (TDA) offers a suite of computational tools that provide quantified shape features in high dimensional data that can be used by modern statistical and predictive machine learning (ML) models. In particular,…

Cryptography and Security · Computer Science 2023-07-06 Dominic Gold , Koray Karabina , Francis C. Motta

Persistent homology is an effective method for extracting topological information, represented as persistent diagrams, of spatial structure data. Hence it is well-suited for the study of protein structures. Attempts to incorporate…

Machine Learning · Computer Science 2024-08-01 An Wu , Yu Pan , Fuqi Zhou , Jinghui Yan , Chuanlu Liu

Topological data analysis (TDA) is gaining prominence across a wide spectrum of machine learning tasks that spans from manifold learning to graph classification. A pivotal technique within TDA is persistent homology (PH), which furnishes an…

Persistent homology is a popular technique in topological data analysis that tracks the lifespans of homological features in a nested sequence of spaces. This data is typically presented in a multi-set called a persistence diagram or a…

Algebraic Topology · Mathematics 2025-11-26 Deni Salja

Topological data analysis involves the statistical characterization of the shape of data. Persistent homology is a primary tool of topological data analysis, which can be used to analyze topological features and perform statistical…

Methodology · Statistics 2023-03-01 Chul Moon , Nicole A. Lazar

We introduce a new feature map for barcodes that arise in persistent homology computation. The main idea is to first realize each barcode as a path in a convenient vector space, and to then compute its path signature which takes values in…

Machine Learning · Statistics 2020-10-28 Ilya Chevyrev , Vidit Nanda , Harald Oberhauser

A fundamental tool in topological data analysis is persistent homology, which allows extraction of information from complex datasets in a robust way. Persistent homology assigns a module over a principal ideal domain to a one-parameter…

Algebraic Topology · Mathematics 2019-06-19 Heather A. Harrington , Nina Otter , Hal Schenck , Ulrike Tillmann

Persistent homology analysis provides means to capture the connectivity structure of data sets in various dimensions. On the mathematical level, by defining a metric between the objects that persistence attaches to data sets, we can…

Machine Learning · Computer Science 2019-06-12 Henri Riihimäki , José Licón-Saláiz

The theory of multidimensional persistent homology was initially developed in the discrete setting, and involved the study of simplicial complexes filtered through an ordering of the simplices. Later, stability properties of…

Computational Geometry · Computer Science 2013-03-28 Niccolò Cavazza , Marc Ethier , Patrizio Frosini , Tomasz Kaczynski , Claudia Landi

Persistence diagrams (PDs), often characterized as sets of death and birth of homology class, have been known for providing a topological representation of a graph structure, which is often useful in machine learning tasks. Prior works rely…

Machine Learning · Computer Science 2022-09-29 Chau Pham , Trung Dang , Peter Chin

Persistent homology (PH) has recently emerged as a powerful tool for extracting topological features. Integrating PH into machine learning and deep learning models enhances topology awareness and interpretability. However, most PH methods…

Machine Learning · Computer Science 2026-01-05 Xinyang Chen , Amaël Broustet , Guanyuan Zeng , Cheng He , Guoting Chen

Persistent homology (PH) is one of the most popular methods in Topological Data Analysis. Even though PH has been used in many different types of applications, the reasons behind its success remain elusive; in particular, it is not known…

Algebraic Topology · Mathematics 2023-01-18 Renata Turkeš , Guido Montúfar , Nina Otter

Persistent homology barcodes and diagrams are a cornerstone of topological data analysis that capture the "shape" of a wide range of complex data structures, such as point clouds, networks, and functions. However, their use in statistical…

Algebraic Topology · Mathematics 2024-09-24 Qiquan Wang , Inés García-Redondo , Pierre Faugère , Gregory Henselman-Petrusek , Anthea Monod

Persistent homology is a widely-used tool in topological data analysis (TDA) for understanding the underlying shape of complex data. By constructing a filtration of simplicial complexes from data points, it captures topological features…

Algebraic Topology · Mathematics 2025-10-23 Aleksei Luchinsky , Umar Islambekov

The local inductive bias of message-passing graph neural networks (GNNs) hampers their ability to exploit key structural information (e.g., connectivity and cycles). Positional encoding (PE) and Persistent Homology (PH) have emerged as two…

Machine Learning · Computer Science 2025-06-09 Yogesh Verma , Amauri H. Souza , Vikas Garg