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Histopathological image analysis is an essential process for the discovery of diseases such as cancer. However, it is challenging to train CNN on whole slide images (WSIs) of gigapixel resolution considering the available memory capacity.…

Image and Video Processing · Electrical Eng. & Systems 2019-10-11 Shusuke Takahama , Yusuke Kurose , Yusuke Mukuta , Hiroyuki Abe , Masashi Fukayama , Akihiko Yoshizawa , Masanobu Kitagawa , Tatsuya Harada

Annotating cancerous regions in whole-slide images (WSIs) of pathology samples plays a critical role in clinical diagnosis, biomedical research, and machine learning algorithms development. However, generating exhaustive and accurate…

Computer Vision and Pattern Recognition · Computer Science 2022-06-09 Zhenzhen Wang , Carla Saoud , Sintawat Wangsiricharoen , Aaron W. James , Aleksander S. Popel , Jeremias Sulam

It is generally accepted that one of the critical parts of current vision algorithms based on deep learning and convolutional neural networks is the annotation of a sufficient number of images to achieve competitive performance. This is…

Computer Vision and Pattern Recognition · Computer Science 2021-03-05 Kai Yao , Alberto Ortiz , Francisco Bonnin-Pascual

Digital histopathology whole slide images (WSIs) provide gigapixel-scale high-resolution images that are highly useful for disease diagnosis. However, digital histopathology image analysis faces significant challenges due to the limited…

Computer Vision and Pattern Recognition · Computer Science 2026-02-13 Bodong Zhang , Xiwen Li , Hamid Manoochehri , Xiaoya Tang , Deepika Sirohi , Beatrice S. Knudsen , Tolga Tasdizen

Deep learning methods show promising results for overlapping cervical cell instance segmentation. However, in order to train a model with good generalization ability, voluminous pixel-level annotations are demanded which is quite expensive…

Computer Vision and Pattern Recognition · Computer Science 2020-07-22 Yanning Zhou , Hao Chen , Huangjing Lin , Pheng-Ann Heng

Pathologists find tedious to examine the status of the sentinel lymph node on a large number of pathological scans. The examination process of such lymph node which encompasses metastasized cancer cells is histopathologically organized.…

Computer Vision and Pattern Recognition · Computer Science 2019-06-25 Amit Kumar Jaiswal , Ivan Panshin , Dimitrij Shulkin , Nagender Aneja , Samuel Abramov

This paper presents a novel unsupervised segmentation method for 3D medical images. Convolutional neural networks (CNNs) have brought significant advances in image segmentation. However, most of the recent methods rely on supervised…

Computer Vision and Pattern Recognition · Computer Science 2018-04-13 Takayasu Moriya , Holger R. Roth , Shota Nakamura , Hirohisa Oda , Kai Nagara , Masahiro Oda , Kensaku Mori

Deep convolutional neural networks (DCNNs) trained on a large number of images with strong pixel-level annotations have recently significantly pushed the state-of-art in semantic image segmentation. We study the more challenging problem of…

Computer Vision and Pattern Recognition · Computer Science 2015-10-07 George Papandreou , Liang-Chieh Chen , Kevin Murphy , Alan L. Yuille

We propose a new and, arguably, a very simple reduction of instance segmentation to semantic segmentation. This reduction allows to train feed-forward non-recurrent deep instance segmentation systems in an end-to-end fashion using…

Computer Vision and Pattern Recognition · Computer Science 2018-07-27 Victor Kulikov , Victor Yurchenko , Victor Lempitsky

We present a pioneering investigation into the application of deep learning techniques to analyze histopathological images for addressing the substantial challenge of automated prognostic prediction. Prognostic prediction poses a unique…

Multiple Instance Learning is the predominant method for Whole Slide Image classification in digital pathology, enabling the use of slide-level labels to supervise model training. Although MIL eliminates the tedious fine-grained annotation…

Computer Vision and Pattern Recognition · Computer Science 2025-05-28 Chen Shu , Boyu Fu , Yiman Li , Ting Yin , Wenchuan Zhang , Jie Chen , Yuhao Yi , Hong Bu

Deep learning has achieved unprecedented success in various object detection tasks with huge amounts of labeled data. However, obtaining large-scale annotations for medical images is extremely challenging due to the high demand of labour…

Image and Video Processing · Electrical Eng. & Systems 2022-03-21 Zhizhong Chai , Luyang Luo , Huangjing Lin , Hao Chen , Anjia Han , Pheng-Ann Heng

Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology…

Quantitative Methods · Quantitative Biology 2023-07-14 Qiehe Sun , Jiawen Li , Jin Xu , Junru Cheng , Tian Guan , Yonghong He

Nucleus instance segmentation in histology images is crucial for a broad spectrum of clinical applications. Current dominant algorithms rely on regression of nuclear proxy maps. Distinguishing nucleus instances from the estimated maps…

Computer Vision and Pattern Recognition · Computer Science 2024-01-25 Zhongyi Shui , Yunlong Zhang , Kai Yao , Chenglu Zhu , Sunyi Zheng , Jingxiong Li , Honglin Li , Yuxuan Sun , Ruizhe Guo , Lin Yang

We tackle biomedical image segmentation in the scenario of only a few labeled brain MR images. This is an important and challenging task in medical applications, where manual annotations are time-consuming. Current multi-atlas based…

Computer Vision and Pattern Recognition · Computer Science 2020-01-14 Hyeon Woo Lee , Mert R. Sabuncu , Adrian V. Dalca

The success of state-of-the-art deep neural networks heavily relies on the presence of large-scale labelled datasets, which are extremely expensive and time-consuming to annotate. This paper focuses on tackling semi-supervised part…

Computer Vision and Pattern Recognition · Computer Science 2022-11-08 Yu Yang , Xiaotian Cheng , Hakan Bilen , Xiangyang Ji

Weakly supervised point cloud semantic segmentation methods that require 1\% or fewer labels, hoping to realize almost the same performance as fully supervised approaches, which recently, have attracted extensive research attention. A…

Computer Vision and Pattern Recognition · Computer Science 2022-09-19 Tianfang Sun , Zhizhong Zhang , Xin Tan , Yanyun Qu , Yuan Xie , Lizhuang Ma

The quantification of biomarkers on immunohistochemistry breast cancer images is essential for defining appropriate therapy for breast cancer patients, as well as for extracting relevant information on disease prognosis. This is an arduous…

Image and Video Processing · Electrical Eng. & Systems 2023-11-27 Blanca Maria Priego-Torresa , Barbara Lobato-Delgado , Lidia Atienza-Cuevas , Daniel Sanchez-Morillo

Histopathology image analysis plays a crucial role in cancer diagnosis. However, training a clinically applicable segmentation algorithm requires pathologists to engage in labour-intensive labelling. In contrast, weakly supervised learning…

Computer Vision and Pattern Recognition · Computer Science 2024-05-28 Gang Xu , Shuhao Wang , Lingyu Zhao , Xiao Chen , Tongwei Wang , Lang Wang , Zhenwei Luo , Dahan Wang , Zewen Zhang , Aijun Liu , Wei Ba , Zhigang Song , Huaiyin Shi , Dingrong Zhong , Jianpeng Ma

Object category localization is a challenging problem in computer vision. Standard supervised training requires bounding box annotations of object instances. This time-consuming annotation process is sidestepped in weakly supervised…

Computer Vision and Pattern Recognition · Computer Science 2016-05-30 Ramazan Gokberk Cinbis , Jakob Verbeek , Cordelia Schmid