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One of the promising methods for the treatment of complex diseases such as cancer is combinational therapy. Due to the combinatorial complexity, machine learning models can be useful in this field, where significant improvements have…

Machine Learning · Computer Science 2020-01-08 Işıksu Ekşioğlu , Mehmet Tan

In recent years dynamical modelling has been provided with a range of breakthrough methods to perform exact Bayesian inference. However it is often computationally unfeasible to apply exact statistical methodologies in the context of large…

Computation · Statistics 2014-12-24 Umberto Picchini , Julie Lyng Forman

Morphing attacks have diversified significantly over the past years, with new methods based on generative adversarial networks (GANs) and diffusion models posing substantial threats to face recognition systems. Recent research has…

Computer Vision and Pattern Recognition · Computer Science 2024-11-13 Laurent Colbois , Sébastien Marcel

Churn prediction in credit cards, fraud detection in insurance, and loan default prediction are important analytical customer relationship management (ACRM) problems. Since frauds, churns and defaults happen less frequently, the datasets…

Machine Learning · Computer Science 2022-02-11 Prateek Kate , Vadlamani Ravi , Akhilesh Gangwar

Recent Large Language Models (LLMs) have demonstrated remarkable capabilities in generating text that closely resembles human writing across wide range of styles and genres. However, such capabilities are prone to potential abuse, such as…

Computation and Language · Computer Science 2023-11-09 Harika Abburi , Kalyani Roy , Michael Suesserman , Nirmala Pudota , Balaji Veeramani , Edward Bowen , Sanmitra Bhattacharya

Artificial intelligence (AI) is increasingly used in every stage of drug development. One challenge facing drug discovery AI is that drug pharmacokinetic (PK) datasets are often collected independently from each other, often with limited…

Quantitative Methods · Quantitative Biology 2025-07-03 Bing Hu , Anita Layton , Helen Chen

Ensembles are popular methods for solving practical supervised learning problems. They reduce the risk of having underperforming models in production-grade software. Although critical, methods for learning heterogeneous regression ensembles…

Machine Learning · Computer Science 2018-04-18 Jihed Khiari , Luis Moreira-Matias , Ammar Shaker , Bernard Zenko , Saso Dzeroski

Multi-omics data integration is crucial for understanding complex diseases, yet limited sample sizes, noise, and heterogeneity often reduce predictive power. To address these challenges, we introduce Omics-GAN, a Generative Adversarial…

Quantitative Methods · Quantitative Biology 2025-10-24 Md Selim Reza , Sabrin Afroz , Mostafizer Rahman , Md Ashad Alam

Bayesian causal discovery aims to infer the posterior distribution over causal models from observed data, quantifying epistemic uncertainty and benefiting downstream tasks. However, computational challenges arise due to joint inference over…

Machine Learning · Computer Science 2023-12-11 Yashas Annadani , Nick Pawlowski , Joel Jennings , Stefan Bauer , Cheng Zhang , Wenbo Gong

Recent advances in large language models (LLMs) have shown great potential to accelerate drug discovery. However, the specialized nature of biochemical data often necessitates costly domain-specific fine-tuning, posing major challenges.…

Machine Learning · Computer Science 2025-11-17 Namkyeong Lee , Edward De Brouwer , Ehsan Hajiramezanali , Tommaso Biancalani , Chanyoung Park , Gabriele Scalia

Self-assembly of dilute sequence-defined macromolecules is a complex phenomenon in which the local arrangement of chemical moieties can lead to the formation of long-range structure. The dependence of this structure on the sequence…

Soft Condensed Matter · Physics 2022-06-08 Debjyoti Bhattacharya , Devon C. Kleeblatt , Antonia Statt , Wesley F. Reinhart

The applications of Artificial Intelligence (AI) methods especially machine learning techniques have increased in recent years. Classification algorithms have been successfully applied to different problems such as requirement…

Software Engineering · Computer Science 2023-02-13 Behnaz Jamasb , Reza Akbari , Seyed Raouf Khayami

Discovering new medicines is the hallmark of human endeavor to live a better and longer life. Yet the pace of discovery has slowed down as we need to venture into more wildly unexplored biomedical space to find one that matches today's high…

Artificial Intelligence · Computer Science 2022-02-16 Tri Minh Nguyen , Thin Nguyen , Truyen Tran

In recent years, Explainable AI (XAI) methods have facilitated profound validation and knowledge extraction from ML models. While extensively studied for classification, few XAI solutions have addressed the challenges specific to regression…

Machine Learning · Computer Science 2025-07-21 Simon Letzgus , Klaus-Robert Müller , Grégoire Montavon

Encrypted network communication ensures confidentiality, integrity, and privacy between endpoints. However, attackers are increasingly exploiting encryption to conceal malicious behavior. Detecting unknown encrypted malicious traffic…

Cryptography and Security · Computer Science 2025-01-10 Sileshi Nibret Zeleke , Amsalu Fentie Jember , Mario Bochicchio

Deep learning (DL) has significantly improved automatic modulation classification (AMC) by leveraging neural networks as the feature extractor.However, as the DL-based AMC becomes increasingly widespread, it is faced with the severe secure…

Signal Processing · Electrical Eng. & Systems 2024-10-16 Jingchun Wang , Peihao Dong , Fuhui Zhou , Qihui Wu

Generative Adversarial Networks (GANs) are a revolutionary class of Deep Neural Networks (DNNs) that have been successfully used to generate realistic images, music, text, and other data. However, GAN training presents many challenges,…

Machine Learning · Computer Science 2022-03-30 Vineel Nagisetty , Laura Graves , Joseph Scott , Vijay Ganesh

Disease heterogeneity has been a critical challenge for precision diagnosis and treatment, especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple distinct brain phenotypes across individuals, potentially…

In semantic segmentation datasets, classes of high importance are oftentimes underrepresented, e.g., humans in street scenes. Neural networks are usually trained to reduce the overall number of errors, attaching identical loss to errors of…

Computer Vision and Pattern Recognition · Computer Science 2019-12-17 Robin Chan , Matthias Rottmann , Fabian Hüger , Peter Schlicht , Hanno Gottschalk

This paper presents a comprehensive comparative analysis of explainable artificial intelligence (XAI) ensembling methods. Our research brings three significant contributions. Firstly, we introduce a novel ensembling method, NormEnsembleXAI,…

Machine Learning · Computer Science 2024-01-31 Weronika Hryniewska-Guzik , Bartosz Sawicki , Przemysław Biecek