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Biologically-informed neural networks typically leverage pathway annotations to enhance performance in biomedical applications. We hypothesized that the benefits of pathway integration does not arise from its biological relevance, but…

Quantitative Methods · Quantitative Biology 2025-05-08 Isabella Caranzano , Corrado Pancotti , Cesare Rollo , Flavio Sartori , Pietro Liò , Piero Fariselli , Tiziana Sanavia

Anti-cancer drug discoveries have been serendipitous, we sought to present the Open Molecular Graph Learning Benchmark, named CandidateDrug4Cancer, a challenging and realistic benchmark dataset to facilitate scalable, robust, and…

Machine Learning · Computer Science 2022-08-23 Xianbin Ye , Ziliang Li , Fei Ma , Zongbi Yi , Pengyong Li , Jun Wang , Peng Gao , Yixuan Qiao , Guotong Xie

Cancer is known as a disease mainly caused by gene alterations. Discovery of mutated driver pathways or gene sets is becoming an important step to understand molecular mechanisms of carcinogenesis. However, systematically investigating…

Genomics · Quantitative Biology 2017-01-02 Junhua Zhang , Shihua Zhang

The identification of cancer genes is a critical yet challenging problem in cancer genomics research. Existing computational methods, including deep graph neural networks, fail to exploit the multilayered gene-gene interactions or provide…

Machine Learning · Computer Science 2023-05-04 Michail Chatzianastasis , Michalis Vazirgiannis , Zijun Zhang

Fault-tolerant Quantum Processing Units (QPUs) promise to deliver exponential speed-ups in select computational tasks, yet their integration into modern deep learning pipelines remains unclear. In this work, we take a step towards bridging…

Quantum Physics · Physics 2026-05-19 Arthur G. Rattew , Po-Wei Huang , Naixu Guo , Lirandë Pira , Patrick Rebentrost

Running Deep Neural Network (DNN) models on devices with limited computational capability is a challenge due to large compute and memory requirements. Quantized Neural Networks (QNNs) have emerged as a potential solution to this problem,…

Computer Vision and Pattern Recognition · Computer Science 2018-05-31 Yaman Umuroglu , Magnus Jahre

Breast cancer diagnosis through thermographic image analysis remains a critical challenge in medical AI, with classical deep learning approaches facing limitations in complex thermal pattern classification tasks. This paper presents a novel…

We introduce a method to train Quantized Neural Networks (QNNs) --- neural networks with extremely low precision (e.g., 1-bit) weights and activations, at run-time. At train-time the quantized weights and activations are used for computing…

Neural and Evolutionary Computing · Computer Science 2016-09-23 Itay Hubara , Matthieu Courbariaux , Daniel Soudry , Ran El-Yaniv , Yoshua Bengio

Developing computational tools for integrative analysis across multiple types of omics data has been of immense importance in cancer molecular biology and precision medicine research. While recent advancements have yielded integrative…

Nuclear segmentation, classification and quantification within Haematoxylin & Eosin stained histology images enables the extraction of interpretable cell-based features that can be used in downstream explainable models in computational…

Computer Vision and Pattern Recognition · Computer Science 2021-11-30 Simon Graham , Mostafa Jahanifar , Quoc Dang Vu , Giorgos Hadjigeorghiou , Thomas Leech , David Snead , Shan E Ahmed Raza , Fayyaz Minhas , Nasir Rajpoot

Accurate identification and localisation of brain tumours from medical images remain challenging due to tumour variability and structural complexity. Convolutional Neural Networks (CNNs), particularly ResNet and Unet, have made significant…

Image and Video Processing · Electrical Eng. & Systems 2024-12-31 Peixin Dai , Jingsi Zhang , Zhitao Shu

Machine learning has recently developed novel approaches, mimicking the synapses of the human brain to achieve similarly efficient learning strategies. Such an approach retains the universality of standard methods, while attempting to…

Identifying the mutations that drive cancer growth is key in clinical decision making and precision oncology. As driver mutations confer selective advantage and thus have an increased likelihood of occurrence, frequency-based statistical…

Genomics · Quantitative Biology 2021-05-04 Adnan Akbar , Andrey Solovyev , John W Cassidy , Nirmesh Patel , Harry W Clifford

The study by Gohr et.al at CRYPTO 2019 and sunsequent related works have shown that neural networks can uncover previously unused features, offering novel insights into cryptanalysis. Motivated by these findings, we employ neural networks…

Cryptography and Security · Computer Science 2025-05-19 Liu Zhang , Yiran Yao , Danping Shi , Dongchen Chai , Jian Guo , Zilong Wang

Breast cancer has long been a prominent cause of mortality among women. Diagnosis, therapy, and prognosis are now possible, thanks to the availability of RNA sequencing tools capable of recording gene expression data. Molecular subtyping…

Machine Learning · Computer Science 2021-11-11 Sheetal Rajpal , Virendra Kumar , Manoj Agarwal , Naveen Kumar

Optimal biomarker combinations for treatment-selection can be derived by minimizing total burden to the population caused by the targeted disease and its treatment. However, when multiple biomarkers are present, including all in the model…

Applications · Statistics 2019-06-07 Sayan Dasgupta , Ying Huang

Recent one-shot Neural Architecture Search algorithms rely on training a hardware-agnostic super-network tailored to a specific task and then extracting efficient sub-networks for different hardware platforms. Popular approaches separate…

Machine Learning · Computer Science 2023-12-22 Sharath Nittur Sridhar , Maciej Szankin , Fang Chen , Sairam Sundaresan , Anthony Sarah

Recurrent Neural Networks are powerful machine learning frameworks that allow for data to be saved and referenced in a temporal sequence. This opens many new possibilities in fields such as handwriting analysis and speech recognition. This…

Machine Learning · Computer Science 2021-09-14 Joseph M. Ackerson , Dave Rushit , Seliya Jim

Quantized deep neural networks (QDNNs) are necessary for low-power, high throughput, and embedded applications. Previous studies mostly focused on developing optimization methods for the quantization of given models. However, quantization…

Machine Learning · Computer Science 2020-06-02 Yoonho Boo , Sungho Shin , Wonyong Sung

Quantized Neural Networks (QNNs), which use low bitwidth numbers for representing parameters and performing computations, have been proposed to reduce the computation complexity, storage size and memory usage. In QNNs, parameters and…

Computer Vision and Pattern Recognition · Computer Science 2017-06-23 Shuchang Zhou , Yuzhi Wang , He Wen , Qinyao He , Yuheng Zou
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