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The growing integration of machine learning (ML) and artificial intelligence (AI) models into high-stakes domains such as healthcare and scientific research calls for models that are not only accurate but also interpretable. Among the…

Machine Learning · Computer Science 2025-10-23 Zhuo Cao , Xuan Zhao , Lena Krieger , Hanno Scharr , Ira Assent

With reference to a binary outcome and a binary mediator, we derive identification bounds for natural effects under a reduced set of assumptions. Specifically, no assumptions about confounding are made that involve the outcome; we only…

Methodology · Statistics 2026-04-03 Marco Doretti , Elena Stanghellini

Counterfactual inference provides a mathematical framework for reasoning about hypothetical outcomes under alternative interventions, bridging causal reasoning and predictive modeling. We present a counterfactual inference framework for…

Machine Learning · Computer Science 2025-10-22 Jingya Cheng , Alaleh Azhir , Jiazi Tian , Hossein Estiri

Machine learning models that operate on graph-structured data, such as molecular graphs or social networks, often make accurate predictions but offer little insight into why certain predictions are made. Counterfactual explanations address…

Machine Learning · Computer Science 2025-11-21 David Bechtoldt , Sidney Bender

In biomedical research, repeated measurements within each subject are often processed to remove artifacts and unwanted sources of variation. The resulting data are used to construct derived outcomes that act as proxies for scientific…

Methodology · Statistics 2026-02-03 Zihang Wang , Razieh Nabi , Benjamin B. Risk

Beneficial to advanced computing devices, models with massive parameters are increasingly employed to extract more information to enhance the precision in describing and predicting the patterns of objective systems. This phenomenon is…

Information Theory · Computer Science 2024-03-08 Liye Jia , Fengyufan Yang , Ka Lok Man , Erick Purwanto , Sheng-Uei Guan , Jeremy Smith , Yutao Yue

Uplift modeling estimates the causal effect of an intervention as the difference between potential outcomes under treatment and control, whereas counterfactual identification aims to recover the joint distribution of these potential…

Machine Learning · Computer Science 2025-12-10 Théo Verhelst , Gianluca Bontempi

Causal parameters may not be point identified in the presence of unobserved confounding. However, information about non-identified parameters, in the form of bounds, may still be recovered from the observed data in some cases. We develop a…

Methodology · Statistics 2020-07-02 Noam Finkelstein , Ilya Shpitser

Counterfactual inference enables clinicians to ask "what if" questions about patient outcomes, but standard methods assume feature independence and simultaneous modifiability -- assumptions violated by longitudinal clinical data. We…

Machine Learning · Computer Science 2026-02-25 Jingya Cheng , Alaleh Azhir , Jiazi Tian , Hossein Estiri

The No Unmeasured Confounding Assumption is widely used to identify causal effects in observational studies. Recent work on proximal inference has provided alternative identification results that succeed even in the presence of unobserved…

Machine Learning · Statistics 2022-10-17 Benjamin Kompa , David R. Bellamy , Thomas Kolokotrones , James M. Robins , Andrew L. Beam

Being able to reason about how one's behaviour can affect the behaviour of others is a core skill required of intelligent driving agents. Despite this, the state of the art struggles to meet the need of agents to discover causal links…

Robotics · Computer Science 2024-03-07 Rhys Howard , Lars Kunze

This paper tackles the problem of time-to-event counterfactual survival prediction, aiming to optimize individualized survival outcomes in the presence of heterogeneity and censored data. We propose CURE, a framework that advances…

Instrumental variable (IV) methods play a central role in causal inference, particularly in settings where treatment assignment is confounded by unobserved variables. IV methods have been extensively developed in recent years and applied…

Counterfactual explanations (CE) explain model decisions by identifying input modifications that lead to different predictions. Most existing methods operate at the instance level. Distributional Counterfactual Explanations (DCE) extend…

Machine Learning · Computer Science 2026-03-18 Yikai Gu , Lele Cao , Bo Zhao , Lei Lei , Lei You

The fundamental problem of causal inference - that the counterfactual outcome for any individual is never observed - has shaped the entire methodology of the field. Every existing approach substitutes assumptions for missing data:…

Artificial Intelligence · Computer Science 2026-04-03 Olav Laudy

In the framework of structural causal models, counterfactual queries describe events that concern multiple alternative states of the system under study. Counterfactual queries often take the form of "what if" type questions such as "would…

Methodology · Statistics 2023-11-23 Santtu Tikka

Most machine learning (ML) models are developed for prediction only; offering no option for causal interpretation of their predictions or parameters/properties. This can hamper the health systems' ability to employ ML models in clinical…

Most existing debiasing methods for multimodal models, including causal intervention and inference methods, utilize approximate heuristics to represent the biases, such as shallow features from early stages of training or unimodal features…

Machine Learning · Computer Science 2023-11-29 Vaidehi Patil , Adyasha Maharana , Mohit Bansal

Recent approaches to causal inference have focused on causal effects defined as contrasts between the distribution of counterfactual outcomes under hypothetical interventions on the nodes of a graphical model. In this article we develop…

Methodology · Statistics 2023-04-26 Iván Díaz

This paper considers (partial) identification of a variety of counterfactual parameters in binary response models with possibly endogenous regressors. Our framework allows for nonseparable index functions with multi-dimensional latent…

Econometrics · Economics 2022-07-26 Jiaying Gu , Thomas M. Russell
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