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Longitudinal targeted maximum likelihood estimation (LTMLE) has very rarely been used to estimate dynamic treatment effects in the context of time-dependent confounding affected by prior treatment when faced with long follow-up times,…

Meta-analyses of observational studies often show substantial between-study heterogeneity, limiting the interpretability of pooled estimates. Meta-regression can be used to explore heterogeneity, but it is often underpowered to handle…

Methodology · Statistics 2026-05-29 Kanella Panagiotopoulou , Theodoros Evrenoglou

The application of transfer learning, leveraging knowledge from source domains to enhance model performance in a target domain, has significantly grown, supporting diverse real-world applications. Its success often relies on shared…

Machine Learning · Computer Science 2024-07-19 Runxue Bao , Yiming Sun , Yuhe Gao , Jindong Wang , Qiang Yang , Zhi-Hong Mao , Ye Ye

When devising a course of treatment for a patient, doctors often have little quantitative evidence on which to base their decisions, beyond their medical education and published clinical trials. Stanford Health Care alone has millions of…

Prediction tasks about students have practical significance for both student and college. Making multiple predictions about students is an important part of a smart campus. For instance, predicting whether a student will fail to graduate…

Machine Learning · Computer Science 2023-09-27 Haobing Liu , Yanmin Zhu , Tianzi Zang , Yanan Xu , Jiadi Yu , Feilong Tang

This paper proposes a doubly robust two-stage semiparametric difference-in-difference estimator for estimating heterogeneous treatment effects with high-dimensional data. Our new estimator is robust to model miss-specifications and allows…

Econometrics · Economics 2020-09-08 Yang Ning , Sida Peng , Jing Tao

The real-world data usually exhibits heterogeneous properties such as modalities, views, or resources, which brings some unique challenges wherein the key is Heterogeneous Representation Learning (HRL) termed in this paper. This brief…

Machine Learning · Computer Science 2020-05-01 Joey Tianyi Zhou , Xi Peng , Yew-Soon Ong

Deep learning models have demonstrated promising results in estimating treatment effects (TEE). However, most of them overlook the variations in treatment outcomes among subgroups with distinct characteristics. This limitation hinders their…

Machine Learning · Computer Science 2024-01-31 Seungyeon Lee , Ruoqi Liu , Wenyu Song , Ping Zhang

We consider Heterogeneous Transfer Learning (HTL) from a source to a new target domain for high-dimensional regression with differing feature sets. Most homogeneous TL methods assume that target and source domains share the same feature…

Machine Learning · Statistics 2025-12-02 Jae Ho Chang , Massimiliano Russo , Subhadeep Paul

In this work we present a method for the statistical analysis of continually monitored data arising in a recurrent diseases problem. The model enables individual level inference in the presence of time transience and population…

Applications · Statistics 2014-11-19 Madhuchhanda Bhattacharjee , Elja Arjas

Machine learning approaches have been effective in predicting adverse outcomes in different clinical settings. These models are often developed and evaluated on datasets with heterogeneous patient populations. However, good predictive…

Machine Learning · Computer Science 2018-06-11 Harini Suresh , Jen J. Gong , John Guttag

Multi-regional clinical trials (MRCTs) enable efficient global drug development by assessing treatment effects across regions within a single protocol. While powered for overall efficacy, MRCTs are typically not designed to provide…

Heterogeneity is a hallmark of complex diseases. Regression-based heterogeneity analysis, which is directly concerned with outcome-feature relationships, has led to a deeper understanding of disease biology. Such an analysis identifies the…

Methodology · Statistics 2022-11-29 Ziye Luo , Xinyue Yao , Yifan Sun , Xinyan Fan

Estimation of heterogeneous treatment effects is an active area of research. Most of the existing methods, however, focus on estimating the conditional average treatment effects of a single, binary treatment given a set of pre-treatment…

Methodology · Statistics 2025-05-30 Max Goplerud , Kosuke Imai , Nicole E. Pashley

The R-learner is widely used in causal inference due to its flexibility and efficiency in estimating the conditional average treatment effect. However, extending the R-learner framework from binary to continuous treatments introduces a…

Methodology · Statistics 2025-04-21 Yichi Zhang , Dehan Kong , Shu Yang

In recent years, there has been growing interest in causal machine learning estimators for quantifying subject-specific effects of a binary treatment on time-to-event outcomes. Estimation approaches have been proposed which attenuate the…

Methodology · Statistics 2026-03-30 Matthew Pryce , Karla Diaz-Ordaz , Ruth H. Keogh , Stijn Vansteelandt

Causal learning is the key to obtaining stable predictions and answering \textit{what if} problems in decision-makings. In causal learning, it is central to seek methods to estimate the average treatment effect (ATE) from observational…

Machine Learning · Statistics 2022-12-07 Yiyan Huang , Cheuk Hang Leung , Qi Wu , Xing Yan

We address the problem of estimating heterogeneous treatment effects in panel data, adopting the popular Difference-in-Differences (DiD) framework under the conditional parallel trends assumption. We propose a novel doubly robust…

Machine Learning · Statistics 2025-04-29 Hui Lan , Haoge Chang , Eleanor Dillon , Vasilis Syrgkanis

The estimation of heterogeneous treatment effects in the potential outcome setting is biased when there exists model misspecification or unobserved confounding. As these biases are unobservable, what model to use when remains a critical…

Methodology · Statistics 2024-05-09 Shonosuke Sugasawa , Kosaku Takanashi , Kenichiro McAlinn , Edoardo M. Airoldi

An important task in drug development is to identify patients, which respond better or worse to an experimental treatment. Identifying predictive covariates, which influence the treatment effect and can be used to define subgroups of…

Methodology · Statistics 2018-11-27 Marius Thomas , Björn Bornkamp , Katja Ickstadt