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Despite continuous advancements in cancer treatment, brain metastatic disease remains a significant complication of primary cancer and is associated with an unfavorable prognosis. One approach for improving diagnosis, management, and…

Other Quantitative Biology · Quantitative Biology 2025-07-11 Nazanin Maleki , Raisa Amiruddin , Ahmed W. Moawad , Nikolay Yordanov , Athanasios Gkampenis , Pascal Fehringer , Fabian Umeh , Crystal Chukwurah , Fatima Memon , Bojan Petrovic , Justin Cramer , Mark Krycia , Elizabeth B. Shrickel , Ichiro Ikuta , Gerard Thompson , Lorenna Vidal , Vilma Kosovic , Adam E. Goldman-Yassen , Virginia Hill , Tiffany So , Sedra Mhana , Albara Alotaibi , Nathan Page , Prisha Bhatia , Melisa S. Guelen , Yasaman Sharifi , Marko Jakovljevic , Salma Abosabie , Sara Abosabie , Mohanad Ghonim , Mohamed Ghonim , Amirreza Manteghinejad , Anastasia Janas , Kiril Krantchev , Maruf Adewole , Jake Albrecht , Udunna Anazodo , Sanjay Aneja , Syed Muhammad Anwar , Timothy Bergquist , Veronica Chiang , Verena Chung , Gian Marco Conte , Farouk Dako , James Eddy , Ivan Ezhov , Nastaran Khalili , Keyvan Farahani , Juan Eugenio Iglesias , Zhifan Jiang , Elaine Johanson , Anahita Fathi Kazerooni , Florian Kofler , Dominic LaBella , Koen Van Leemput , Hongwei Bran Li , Marius George Linguraru , Xinyang Liu , Zeke Meier , Bjoern H Menze , Harrison Moy , Klara Osenberg , Marie Piraud , Zachary Reitman , Russell Takeshi Shinohara , Chunhao Wang , Benedikt Wiestler , Walter Wiggins , Umber Shafique , Klara Willms , Arman Avesta , Khaled Bousabarah , Satrajit Chakrabarty , Nicolo Gennaro , Wolfgang Holler , Manpreet Kaur , Pamela LaMontagne , MingDe Lin , Jan Lost , Daniel S. Marcus , Ryan Maresca , Sarah Merkaj , Gabriel Cassinelli Pedersen , Marc von Reppert , Aristeidis Sotiras , Oleg Teytelboym , Niklas Tillmans , Malte Westerhoff , Ayda Youssef , Devon Godfrey , Scott Floyd , Andreas Rauschecker , Javier Villanueva-Meyer , Irada Pflüger , Jaeyoung Cho , Martin Bendszus , Gianluca Brugnara , Gloria J. Guzman Perez-Carillo , Derek R. Johnson , Anthony Kam , Benjamin Yin Ming Kwan , Lillian Lai , Neil U. Lall , Satya Narayana Patro , Lei Wu , Anu Bansal , Frederik Barkhof , Cristina Besada , Sammy Chu , Jason Druzgal , Alexandru Dusoi , Luciano Farage , Fabricio Feltrin , Amy Fong , Steve H. Fung , R. Ian Gray , Michael Iv , Alida A. Postma , Amit Mahajan , David Joyner , Chase Krumpelman , Laurent Letourneau-Guillon , Christie M. Lincoln , Mate E. Maros , Elka Miller , Fanny Morón , Esther A. Nimchinsky , Ozkan Ozsarlak , Uresh Patel , Saurabh Rohatgi , Atin Saha , Anousheh Sayah , Eric D. Schwartz , Robert Shih , Mark S. Shiroishi , Juan E. Small , Manoj Tanwar , Jewels Valerie , Brent D. Weinberg , Matthew L. White , Robert Young , Vahe M. Zohrabian , Aynur Azizova , Melanie Maria Theresa Brüßeler , Abdullah Okar , Luca Pasquini , Yasaman Sharifi , Gagandeep Singh , Nico Sollmann , Theodora Soumala , Mahsa Taherzadeh , Philipp Vollmuth , Martha Foltyn-Dumitru , Ajay Malhotra , Francesco Dellepiane , Víctor M. Pérez-García , Hesham Elhalawani , Maria Correia de Verdier , Sanaria Al Rubaiey , Rui Duarte Armindo , Kholod Ashraf , Moamen M. Asla , Mohamed Badawy , Jeroen Bisschop , Nima Broomand Lomer , Jan Bukatz , Jim Chen , Petra Cimflova , Felix Corr , Alexis Crawley , Lisa Deptula , Tasneem Elakhdar , Islam H. Shawali , Shahriar Faghani , Alexandra Frick , Vaibhav Gulati , Muhammad Ammar Haider , Fátima Hierro , Rasmus Holmboe Dahl , Sarah Maria Jacobs , Kuang-chun Jim Hsieh , Sedat G. Kandemirli , Katharina Kersting , Laura Kida , Sofia Kollia , Ioannis Koukoulithras , Xiao Li , Ahmed Abouelatta , Aya Mansour , Ruxandra-Catrinel Maria-Zamfirescu , Marcela Marsiglia , Yohana Sarahi Mateo-Camacho , Mark McArthur , Olivia McDonnel , Maire McHugh , Mana Moassefi , Samah Mostafa Morsi , Alexander Munteanu , Khanak K. Nandolia , Syed Raza Naqvi , Yalda Nikanpour , Mostafa Alnoury , Abdullah Mohamed Aly Nouh , Francesca Pappafava , Markand D. Patel , Samantha Petrucci , Eric Rawie , Scott Raymond , Borna Roohani , Sadeq Sabouhi , Laura M. Sanchez Garcia , Zoe Shaked , Pokhraj P. Suthar , Talissa Altes , Edvin Isufi , Yaseen Dhemesh , Jaime Gass , Jonathan Thacker , Abdul Rahman Tarabishy , Benjamin Turner , Sebastiano Vacca , George K. Vilanilam , Daniel Warren , David Weiss , Fikadu Worede , Sara Yousry , Wondwossen Lerebo , Alejandro Aristizabal , Alexandros Karargyris , Hasan Kassem , Sarthak Pati , Micah Sheller , Katherine E. Link , Evan Calabrese , Nourel Hoda Tahon , Ayman Nada , Jeffrey D. Rudie , Janet Reid , Kassa Darge , Aly H. Abayazeed , Philipp Lohmann , Yuri S. Velichko , Spyridon Bakas , Mariam Aboian

We describe the design and results from the BraTS 2023 Intracranial Meningioma Segmentation Challenge. The BraTS Meningioma Challenge differed from prior BraTS Glioma challenges in that it focused on meningiomas, which are typically benign…

Image and Video Processing · Electrical Eng. & Systems 2025-03-10 Dominic LaBella , Ujjwal Baid , Omaditya Khanna , Shan McBurney-Lin , Ryan McLean , Pierre Nedelec , Arif Rashid , Nourel Hoda Tahon , Talissa Altes , Radhika Bhalerao , Yaseen Dhemesh , Devon Godfrey , Fathi Hilal , Scott Floyd , Anastasia Janas , Anahita Fathi Kazerooni , John Kirkpatrick , Collin Kent , Florian Kofler , Kevin Leu , Nazanin Maleki , Bjoern Menze , Maxence Pajot , Zachary J. Reitman , Jeffrey D. Rudie , Rachit Saluja , Yury Velichko , Chunhao Wang , Pranav Warman , Maruf Adewole , Jake Albrecht , Udunna Anazodo , Syed Muhammad Anwar , Timothy Bergquist , Sully Francis Chen , Verena Chung , Rong Chai , Gian-Marco Conte , Farouk Dako , James Eddy , Ivan Ezhov , Nastaran Khalili , Juan Eugenio Iglesias , Zhifan Jiang , Elaine Johanson , Koen Van Leemput , Hongwei Bran Li , Marius George Linguraru , Xinyang Liu , Aria Mahtabfar , Zeke Meier , Ahmed W. Moawad , John Mongan , Marie Piraud , Russell Takeshi Shinohara , Walter F. Wiggins , Aly H. Abayazeed , Rachel Akinola , András Jakab , Michel Bilello , Maria Correia de Verdier , Priscila Crivellaro , Christos Davatzikos , Keyvan Farahani , John Freymann , Christopher Hess , Raymond Huang , Philipp Lohmann , Mana Moassefi , Matthew W. Pease , Phillipp Vollmuth , Nico Sollmann , David Diffley , Khanak K. Nandolia , Daniel I. Warren , Ali Hussain , Pascal Fehringer , Yulia Bronstein , Lisa Deptula , Evan G. Stein , Mahsa Taherzadeh , Eduardo Portela de Oliveira , Aoife Haughey , Marinos Kontzialis , Luca Saba , Benjamin Turner , Melanie M. T. Brüßeler , Shehbaz Ansari , Athanasios Gkampenis , David Maximilian Weiss , Aya Mansour , Islam H. Shawali , Nikolay Yordanov , Joel M. Stein , Roula Hourani , Mohammed Yahya Moshebah , Ahmed Magdy Abouelatta , Tanvir Rizvi , Klara Willms , Dann C. Martin , Abdullah Okar , Gennaro D'Anna , Ahmed Taha , Yasaman Sharifi , Shahriar Faghani , Dominic Kite , Marco Pinho , Muhammad Ammar Haider , Alejandro Aristizabal , Alexandros Karargyris , Hasan Kassem , Sarthak Pati , Micah Sheller , Michelle Alonso-Basanta , Javier Villanueva-Meyer , Andreas M. Rauschecker , Ayman Nada , Mariam Aboian , Adam E. Flanders , Benedikt Wiestler , Spyridon Bakas , Evan Calabrese

The 2024 Brain Tumor Segmentation Meningioma Radiotherapy (BraTS-MEN-RT) challenge aimed to advance automated segmentation algorithms using the largest known multi-institutional dataset of 750 radiotherapy planning brain MRIs with…

Computer Vision and Pattern Recognition · Computer Science 2025-07-23 Dominic LaBella , Valeriia Abramova , Mehdi Astaraki , Andre Ferreira , Zhifan Jiang , Mason C. Cleveland , Ramandeep Kang , Uma M. Lal-Trehan Estrada , Cansu Yalcin , Rachika E. Hamadache , Clara Lisazo , Adrià Casamitjana , Joaquim Salvi , Arnau Oliver , Xavier Lladó , Iuliana Toma-Dasu , Tiago Jesus , Behrus Puladi , Jens Kleesiek , Victor Alves , Jan Egger , Daniel Capellán-Martín , Abhijeet Parida , Austin Tapp , Xinyang Liu , Maria J. Ledesma-Carbayo , Jay B. Patel , Thomas N. McNeal , Maya Viera , Owen McCall , Albert E. Kim , Elizabeth R. Gerstner , Christopher P. Bridge , Katherine Schumacher , Michael Mix , Kevin Leu , Shan McBurney-Lin , Pierre Nedelec , Javier Villanueva-Meyer , David R. Raleigh , Jonathan Shapey , Tom Vercauteren , Kazumi Chia , Marina Ivory , Theodore Barfoot , Omar Al-Salihi , Justin Leu , Lia M. Halasz , Yuri S. Velichko , Chunhao Wang , John P. Kirkpatrick , Scott R. Floyd , Zachary J. Reitman , Trey C. Mullikin , Eugene J. Vaios , Christina Huang , Ulas Bagci , Sean Sachdev , Jona A. Hattangadi-Gluth , Tyler M. Seibert , Nikdokht Farid , Connor Puett , Matthew W. Pease , Kevin Shiue , Syed Muhammad Anwar , Shahriar Faghani , Peter Taylor , Pranav Warman , Jake Albrecht , András Jakab , Mana Moassefi , Verena Chung , Rong Chai , Alejandro Aristizabal , Alexandros Karargyris , Hasan Kassem , Sarthak Pati , Micah Sheller , Nazanin Maleki , Rachit Saluja , Florian Kofler , Christopher G. Schwarz , Philipp Lohmann , Phillipp Vollmuth , Louis Gagnon , Maruf Adewole , Hongwei Bran Li , Anahita Fathi Kazerooni , Nourel Hoda Tahon , Udunna Anazodo , Ahmed W. Moawad , Bjoern Menze , Marius George Linguraru , Mariam Aboian , Benedikt Wiestler , Ujjwal Baid , Gian-Marco Conte , Andreas M. Rauschecker , Ayman Nada , Aly H. Abayazeed , Raymond Huang , Maria Correia de Verdier , Jeffrey D. Rudie , Spyridon Bakas , Evan Calabrese

Brain tumor segmentation is a critical task for patient's disease management. In order to automate and standardize this task, we trained multiple U-net like neural networks, mainly with deep supervision and stochastic weight averaging, on…

Image and Video Processing · Electrical Eng. & Systems 2020-11-30 Theophraste Henry , Alexandre Carre , Marvin Lerousseau , Theo Estienne , Charlotte Robert , Nikos Paragios , Eric Deutsch

Automatic segmentation of brain tumors is an essential but challenging step for extracting quantitative imaging biomarkers for accurate tumor detection, diagnosis, prognosis, treatment planning and assessment. Multimodal Brain Tumor…

Image and Video Processing · Electrical Eng. & Systems 2020-11-30 Yading Yuan

Automatic segmentation is essential for the brain tumor diagnosis, disease prognosis, and follow-up therapy of patients with gliomas. Still, accurate detection of gliomas and their sub-regions in multimodal MRI is very challenging due to…

Image and Video Processing · Electrical Eng. & Systems 2022-12-20 Ramy A. Zeineldin , Mohamed E. Karar , Oliver Burgert , Franziska Mathis-Ullrich

Accurate and automatic segmentation of brain tumors in multi-parametric magnetic resonance imaging (mpMRI) is essential for quantitative measurements, which play an increasingly important role in clinical diagnosis and prognosis. The…

Tumor segmentation from multi-modal brain MRI images is a challenging task due to the limited samples, high variance in shapes and uneven distribution of tumor morphology. The performance of automated medical image segmentation has been…

Image and Video Processing · Electrical Eng. & Systems 2024-02-13 Tianyi Ren , Ethan Honey , Harshitha Rebala , Abhishek Sharma , Agamdeep Chopra , Mehmet Kurt

Automated segmentation proves to be a valuable tool in precisely detecting tumors within medical images. The accurate identification and segmentation of tumor types hold paramount importance in diagnosing, monitoring, and treating highly…

Image and Video Processing · Electrical Eng. & Systems 2024-03-15 Fadillah Maani , Anees Ur Rehman Hashmi , Mariam Aljuboory , Numan Saeed , Ikboljon Sobirov , Mohammad Yaqub

Segmenting brain tumors in multi-parametric magnetic resonance imaging enables performing quantitative analysis in support of clinical trials and personalized patient care. This analysis provides the potential to impact clinical…

Resection and whole brain radiotherapy (WBRT) are the standards of care for the treatment of patients with brain metastases (BM) but are often associated with cognitive side effects. Stereotactic radiosurgery (SRS) involves a more targeted…

Brain metastases (BMs) are the most frequently occurring brain tumors. The treatment of patients having multiple BMs with stereo tactic radiosurgery necessitates accurate localization of the metastases. Neural networks can assist in this…

Image and Video Processing · Electrical Eng. & Systems 2023-10-05 Ayhan Can Erdur , Daniel Scholz , Josef A. Buchner , Stephanie E. Combs , Daniel Rueckert , Jan C. Peeken

Background: Brain tumor segmentation has a significant impact on the diagnosis and treatment of brain tumors. Accurate brain tumor segmentation remains challenging due to their irregular shapes, vague boundaries, and high variability.…

Computer Vision and Pattern Recognition · Computer Science 2025-05-07 Zhanyuan Jia , Ni Yao , Danyang Sun , Chuang Han , Yanting Li , Jiaofen Nan , Fubao Zhu , Chen Zhao , Weihua Zhou

This manuscript describes the first challenge on Federated Learning, namely the Federated Tumor Segmentation (FeTS) challenge 2021. International challenges have become the standard for validation of biomedical image analysis methods.…

In the realm of medical diagnostics, rapid advancements in Artificial Intelligence (AI) have significantly yielded remarkable improvements in brain tumor segmentation. Encoder-Decoder architectures, such as U-Net, have played a…

Computer Vision and Pattern Recognition · Computer Science 2025-10-23 Eyad Gad , Seif Soliman , M. Saeed Darweesh

Gliomas are the most common malignant primary brain tumors in adults and one of the deadliest types of cancer. There are many challenges in treatment and monitoring due to the genetic diversity and high intrinsic heterogeneity in…

Computer Vision and Pattern Recognition · Computer Science 2024-05-29 Maria Correia de Verdier , Rachit Saluja , Louis Gagnon , Dominic LaBella , Ujjwall Baid , Nourel Hoda Tahon , Martha Foltyn-Dumitru , Jikai Zhang , Maram Alafif , Saif Baig , Ken Chang , Gennaro D'Anna , Lisa Deptula , Diviya Gupta , Muhammad Ammar Haider , Ali Hussain , Michael Iv , Marinos Kontzialis , Paul Manning , Farzan Moodi , Teresa Nunes , Aaron Simon , Nico Sollmann , David Vu , Maruf Adewole , Jake Albrecht , Udunna Anazodo , Rongrong Chai , Verena Chung , Shahriar Faghani , Keyvan Farahani , Anahita Fathi Kazerooni , Eugenio Iglesias , Florian Kofler , Hongwei Li , Marius George Linguraru , Bjoern Menze , Ahmed W. Moawad , Yury Velichko , Benedikt Wiestler , Talissa Altes , Patil Basavasagar , Martin Bendszus , Gianluca Brugnara , Jaeyoung Cho , Yaseen Dhemesh , Brandon K. K. Fields , Filip Garrett , Jaime Gass , Lubomir Hadjiiski , Jona Hattangadi-Gluth , Christopher Hess , Jessica L. Houk , Edvin Isufi , Lester J. Layfield , George Mastorakos , John Mongan , Pierre Nedelec , Uyen Nguyen , Sebastian Oliva , Matthew W. Pease , Aditya Rastogi , Jason Sinclair , Robert X. Smith , Leo P. Sugrue , Jonathan Thacker , Igor Vidic , Javier Villanueva-Meyer , Nathan S. White , Mariam Aboian , Gian Marco Conte , Anders Dale , Mert R. Sabuncu , Tyler M. Seibert , Brent Weinberg , Aly Abayazeed , Raymond Huang , Sevcan Turk , Andreas M. Rauschecker , Nikdokht Farid , Philipp Vollmuth , Ayman Nada , Spyridon Bakas , Evan Calabrese , Jeffrey D. Rudie

The BraTS 2021 challenge celebrates its 10th anniversary and is jointly organized by the Radiological Society of North America (RSNA), the American Society of Neuroradiology (ASNR), and the Medical Image Computing and Computer Assisted…

Computer Vision and Pattern Recognition · Computer Science 2021-09-14 Ujjwal Baid , Satyam Ghodasara , Suyash Mohan , Michel Bilello , Evan Calabrese , Errol Colak , Keyvan Farahani , Jayashree Kalpathy-Cramer , Felipe C. Kitamura , Sarthak Pati , Luciano M. Prevedello , Jeffrey D. Rudie , Chiharu Sako , Russell T. Shinohara , Timothy Bergquist , Rong Chai , James Eddy , Julia Elliott , Walter Reade , Thomas Schaffter , Thomas Yu , Jiaxin Zheng , Ahmed W. Moawad , Luiz Otavio Coelho , Olivia McDonnell , Elka Miller , Fanny E. Moron , Mark C. Oswood , Robert Y. Shih , Loizos Siakallis , Yulia Bronstein , James R. Mason , Anthony F. Miller , Gagandeep Choudhary , Aanchal Agarwal , Cristina H. Besada , Jamal J. Derakhshan , Mariana C. Diogo , Daniel D. Do-Dai , Luciano Farage , John L. Go , Mohiuddin Hadi , Virginia B. Hill , Michael Iv , David Joyner , Christie Lincoln , Eyal Lotan , Asako Miyakoshi , Mariana Sanchez-Montano , Jaya Nath , Xuan V. Nguyen , Manal Nicolas-Jilwan , Johanna Ortiz Jimenez , Kerem Ozturk , Bojan D. Petrovic , Chintan Shah , Lubdha M. Shah , Manas Sharma , Onur Simsek , Achint K. Singh , Salil Soman , Volodymyr Statsevych , Brent D. Weinberg , Robert J. Young , Ichiro Ikuta , Amit K. Agarwal , Sword C. Cambron , Richard Silbergleit , Alexandru Dusoi , Alida A. Postma , Laurent Letourneau-Guillon , Gloria J. Guzman Perez-Carrillo , Atin Saha , Neetu Soni , Greg Zaharchuk , Vahe M. Zohrabian , Yingming Chen , Milos M. Cekic , Akm Rahman , Juan E. Small , Varun Sethi , Christos Davatzikos , John Mongan , Christopher Hess , Soonmee Cha , Javier Villanueva-Meyer , John B. Freymann , Justin S. Kirby , Benedikt Wiestler , Priscila Crivellaro , Rivka R. Colen , Aikaterini Kotrotsou , Daniel Marcus , Mikhail Milchenko , Arash Nazeri , Hassan Fathallah-Shaykh , Roland Wiest , Andras Jakab , Marc-Andre Weber , Abhishek Mahajan , Bjoern Menze , Adam E. Flanders , Spyridon Bakas

Automated brain tumor segmentation methods have become well-established and reached performance levels offering clear clinical utility. These methods typically rely on four input magnetic resonance imaging (MRI) modalities: T1-weighted…

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