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Protein structure prediction can be shown to be an NP-hard problem; the number of conformations grows exponentially with the number of residues. The native conformations of proteins occupy a very small subset of these, hence an exploratory,…

Chemical Physics · Physics 2008-02-03 Mehul M. Khimasia , Peter V. Coveney

Disease-gene prediction (DGP) refers to the computational challenge of predicting associations between genes and diseases. Effective solutions to the DGP problem have the potential to accelerate the therapeutic development pipeline at early…

Machine Learning · Computer Science 2019-07-15 Vikash Singh , Pietro Lio'

Deep neural networks are typically trained by uniformly sampling large datasets across epochs, despite evidence that not all samples contribute equally throughout learning. Recent work shows that progressively reducing the amount of…

Machine Learning · Computer Science 2026-04-15 Amar Gahir , Varshil Patel , Shreyank N Gowda

The choice of parameters, and the design of the network architecture are important factors affecting the performance of deep neural networks. Genetic Algorithms (GA) have been used before to determine parameters of a network. Yet, GAs…

Computer Vision and Pattern Recognition · Computer Science 2018-09-28 Yantao Lu , Burak Kakillioglu , Senem Velipasalar

Routing configurations of a network should constantly adapt to traffic variations to achieve good network performance. Adaptive routing faces two main challenges: 1) how to accurately measure/estimate time-varying traffic matrices? 2) how…

Networking and Internet Architecture · Computer Science 2025-08-21 Zhun Yin , Xiaotian Li , Lifan Mei , Yong Liu , Zhong-Ping Jiang

Self-adaptive software can assess and modify its behavior when the assessment indicates that the program is not performing as intended or when improved functionality or performance is available. Since the mid-1960s, the subject of system…

Software Engineering · Computer Science 2023-02-14 Tarik A. Rashid , Bryar A. Hassan , Abeer Alsadoon , Shko Qader , S. Vimal , Amit Chhabra , Zaher Mundher Yaseen

This paper presents a spanning tree-based genetic algorithm (GA) for the reconfiguration of electrical distribution systems with the objective of minimizing active power losses. Due to low voltage levels at distribution systems, power…

Systems and Control · Electrical Eng. & Systems 2020-08-19 Mukesh Gautam , Narayan Bhusal , Mohammed Benidris , Sushil J. Louis

Neural network optimization remains one of the most consequential yet poorly understood challenges in modern AI research, where improvements in training algorithms can lead to enhanced feature learning in foundation models,…

Machine Learning · Computer Science 2025-12-23 Ansh Nagwekar

Generally, when genetic programming (GP) is used for function synthesis any valuable experience gained by the system is lost from one problem to the next, even when the problems are closely related. With the aim of developing a system which…

Neural and Evolutionary Computing · Computer Science 2015-05-07 Robyn Ffrancon

This paper presents a powerful automated framework for making complex systems resilient under failures, by optimized adaptive distribution and replication of interdependent software components across heterogeneous hardware components with…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-06-13 Scott D. Stoller , Balaji Jayasankar , Yanhong A. Liu

There are two common approaches for optimizing the performance of a machine: genetic algorithms and machine learning. A genetic algorithm is applied over many generations whereas machine learning works by applying feedback until the system…

Artificial Intelligence · Computer Science 2017-09-01 Leigh Sheneman , Arend Hintze

Networks are designed with functionality, security, performance, and cost in mind. Tools exist to check or optimize individual properties of a network. These properties may conflict, so it is not always possible to run these tools in series…

Cryptography and Security · Computer Science 2019-02-19 Timothy Curry , Devon Callahan , Benjamin Fuller , Laurent Michel

Cyber security adversaries and engagements are ubiquitous and ceaseless. We delineate Adversarial Genetic Programming for Cyber Security, a research topic that, by means of genetic programming (GP), replicates and studies the behavior of…

The choice of parameters, and the design of the network architecture are important factors affecting the performance of deep neural networks. However, there has not been much work on developing an established and systematic way of building…

Neural and Evolutionary Computing · Computer Science 2018-05-25 Burak Kakillioglu , Yantao Lu , Senem Velipasalar

Voltage control in power distribution networks has been greatly challenged by the increasing penetration of volatile and intermittent devices. These devices can also provide limited reactive power resources that can be used to regulate the…

Systems and Control · Computer Science 2016-07-26 Hao Jan Liu , Wei Shi , Hao Zhu

Search Based Software Testing (SBST) is a popular automated testing technique which uses a feedback mechanism to search for faults in software. Despite its popularity, it has fundamental challenges related to the design, construction and…

Software Engineering · Computer Science 2020-07-01 Leonid Joffe , David J. Clark

Graph classification is a pivotal challenge in machine learning, especially within the realm of graph-based data, given its importance in numerous real-world applications such as social network analysis, recommendation systems, and…

Machine Learning · Computer Science 2024-07-03 Bowen Zhang , Zhichao Huang , Genan Dai , Guangning Xu , Xiaomao Fan , Hu Huang

We introduce a soft computing approach for automatically selecting and combining indices from remote sensing multispectral images that can be used for classification tasks. The proposed approach is based on a Genetic-Programming (GP)…

Neural and Evolutionary Computing · Computer Science 2020-11-11 Juan F. H. Albarracín , Rafael S. Oliveira , Marina Hirota , Jefersson A. dos Santos , Ricardo da S. Torres

With the increasing number of intrusions in system and network infrastructures, Intrusion Detection Systems (IDS) have become an active area of research to develop reliable and effective solutions to detect and counter them. The use of…

Cryptography and Security · Computer Science 2012-12-04 Herve Kabamba Mbikayi

We present the Star-Based Automated Single-locus and Epistasis analysis tool - Genetic Programming (StarBASE-GP), an automated framework for discovering meaningful genetic variants associated with phenotypic variation in large-scale genomic…

Neural and Evolutionary Computing · Computer Science 2025-05-30 Jose Guadalupe Hernandez , Attri Ghosh , Philip J. Freda , Yufei Meng , Nicholas Matsumoto , Jason H. Moore