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The development of machine learning for cardiac care is severely hampered by privacy restrictions on sharing real patient electrocardiogram (ECG) data. Although generative AI offers a promising solution, the real-world use of existing…

Many clinical deep learning algorithms are population-based and difficult to interpret. Such properties limit their clinical utility as population-based findings may not generalize to individual patients and physicians are reluctant to…

Signal Processing · Electrical Eng. & Systems 2020-12-01 Dani Kiyasseh , Tingting Zhu , David A. Clifton

A continuum model of epithelial tissue mechanics was formulated using cellular-level mechanical ingredients and cell morphogenetic processes, including cellular shape changes and cellular rearrangements. This model can include finite…

Tissues and Organs · Quantitative Biology 2017-09-06 Shuji Ishihara , Philippe Marcq , Kaoru Sugimura

In the context of embodied artificial intelligence, morphological computation refers to processes which are conducted by the body (and environment) that otherwise would have to be performed by the brain. Exploiting environmental and…

Artificial Intelligence · Computer Science 2016-07-13 Keyan Ghazi-Zahedi , Daniel F. B. Haeufle , Guido Montufar , Syn Schmitt , Nihat Ay

Aortic stenosis (AS) is the most common valvular heart disease in developed countries. High-fidelity preclinical models can improve AS management by enabling therapeutic innovation, early diagnosis, and tailored treatment planning. However,…

Computational Engineering, Finance, and Science · Computer Science 2024-07-02 Caglar Ozturk , Daniel H. Pak , Luca Rosalia , Debkalpa Goswami , Mary E. Robakowski , Raymond McKay , Christopher T. Nguyen , James S. Duncan , Ellen T. Roche

Deep learning (DL) based predictive models from electronic health records (EHR) deliver impressive performance in many clinical tasks. Large training cohorts, however, are often required to achieve high accuracy, hindering the adoption of…

Computation and Language · Computer Science 2020-05-27 Laila Rasmy , Yang Xiang , Ziqian Xie , Cui Tao , Degui Zhi

Neurological and Physiological Disorders that impact emotional regulation each have their own unique characteristics which are important to understand in order to create a generalized solution to all of them. The purpose of this experiment…

Human-Computer Interaction · Computer Science 2024-11-25 Vedant Mehta

Creating haptic interfaces capable of rendering the rich sensation needed for dexterous manipulation is crucial for the advancement of human-in-the-loop telerobotic systems (HiLTS). One limiting factor has been the absence of detailed…

Robotics · Computer Science 2021-07-23 Mohit Singhala , Jeremy D. Brown

Background: Transcranial magnetic stimulation (TMS) is a powerful tool to investigate neurophysiology of the human brain and treat brain disorders. Traditionally, therapeutic TMS has been applied in a one-size-fits-all approach,…

We provide an accessible description of a peer-reviewed generalizable causal machine learning pipeline to (i) discover latent causal sources of large-scale electronic health records observations, and (ii) quantify the source causal effects…

Machine Learning · Computer Science 2025-11-03 Marco Barbero-Mota , Eric V. Strobl , John M. Still , William W. Stead , Thomas A. Lasko

Electronic health records (EHRs) contain a vast amount of high-dimensional multi-modal data that can accurately represent a patient's medical history. Unfortunately, most of this data is either unstructured or semi-structured, rendering it…

Computation and Language · Computer Science 2023-12-06 Ashwyn Sharma , David I. Feldman , Aneesh Jain

This chapter presents an innovative framework for the application of machine learning and data analytics for the identification of alloys or composites exhibiting certain desired properties of interest. The main focus is on alloys and…

Materials Science · Physics 2020-12-15 Baldur Steingrimsson , Xuesong Fan , Anand Kulkarni , Michael C. Gao , Peter K. Liaw

Generative models have been found effective for data synthesis due to their ability to capture complex underlying data distributions. The quality of generated data from these models is commonly evaluated by visual inspection for image…

Machine Learning · Computer Science 2022-10-18 Emily Muller , Xu Zheng , Jer Hayes

Heart rate variability (HRV) is a well-known phenomenon whose characteristics are of great clinical relevance in pathophysiologic investigations. In particular, respiration is a powerful modulator of HRV contributing to the oscillations at…

Tissues and Organs · Quantitative Biology 2015-06-26 R. Balocchi , D. Menicucci , E. Santarcangelo , L. Sebastiani , A. Gemignani , B. Ghelarducci , M. Varanini

The heterogeneous micromechanical properties of biological tissues have profound implications across diverse medical and engineering domains. However, identifying full-field heterogeneous elastic properties of soft materials using…

Numerical Analysis · Mathematics 2025-07-09 Wensi Wu , Mitchell Daneker , Kevin T. Turner , Matthew A. Jolley , Lu Lu

A severe application of stress on articular cartilage can initiate a cascade of biochemical reactions that can lead to the development of osteoarthritis. We constructed a multiscale mathematical model of the process with three components:…

Tissues and Organs · Quantitative Biology 2023-02-14 Georgi I. Kapitanov , Xiayi Wang , Bruce P. Ayati , Marc J. Brouillette , James A. Martin

Tendon-bone enthesis connects tendon and bone, two mechanically dissimilar materials, while effectively minimizing stress concentrations, a capability rarely achieved in engineering materials. Its hierarchical organization and graded…

Soft Condensed Matter · Physics 2026-04-14 Zhangke Yang , Zhaoxu Meng

The Electrocardiograph signal represents the heart's electrical activity while blood pressure results from the heart's mechanical activity. Previous studies have investigated how the heart's electrical and mechanical activities are related…

Signal Processing · Electrical Eng. & Systems 2020-08-25 Seyedeh Somayyeh Mousavi , Mostafa Charmi , Mohammad Firouzmand , Mohammad Hemmati , Maryam Moghadam , Yadollah Ghorbani

While computational modeling may help to develop new treatment options for hand and wrist injuries, at present, few models exist. The time and expertise required to develop and use these models is considerable. Moreover, most do not allow…

Quantitative Methods · Quantitative Biology 2025-05-27 Thor E. Andreassen , Taylor P. Trentadue , Andrew R. Thoreson , Kai-Nan An , Sanjeev Kakar , Kristin D. Zhao

Patients resuscitated from cardiac arrest (CA) face a high risk of neurological disability and death, however pragmatic methods are lacking for accurate and reliable prognostication. The aim of this study was to build computational models…

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