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The automated construction of coarse-grained models represents a pivotal component in computer simulation of physical systems and is a key enabler in various analysis and design tasks related to uncertainty quantification. Pertinent methods…

Machine Learning · Statistics 2019-09-11 Constantin Grigo , Phaedon-Stelios Koutsourelakis

Stochastic kinetic models describe systems across biology, chemistry, and physics where discrete events and small populations render deterministic approximations inadequate. Parameter inference and inverse design in these systems require…

Computational Physics · Physics 2026-03-06 Francesco Mottes , Qian-Ze Zhu , Michael P. Brenner

We develop a quadratic regularization approach for the solution of high-dimensional multistage stochastic optimization problems characterized by a potentially large number of time periods/stages (e.g. hundreds), a high-dimensional resource…

Optimization and Control · Mathematics 2017-02-28 Tsvetan Asamov , Warren B. Powell

Developing physics-based models for molecular simulation requires fitting many unknown parameters to diverse experimental datasets. Traditionally, this process is piecemeal and difficult to reproduce, leading to a fragmented landscape of…

Biological Physics · Physics 2025-04-10 Ryan K. Krueger , Megan C. Engel , Ryan Hausen , Michael P. Brenner

We present a detailed derivation and testing of our approach to rescale the dynamics of mesoscale simulations of coarse-grained polymer melts (I. Y. Lyubimov et al. J. Chem. Phys. \textbf{132}, 11876, 2010). Starting from the…

Soft Condensed Matter · Physics 2015-05-27 I. Y. Lyubimov , M. G. Guenza

We consider the problem of coarse-graining in the context of finite-volume fluid models. If a variable is defined on a high-resolution grid it may be coarse-grained so that it is defined on a grid of lower resolution. In general this will…

Atmospheric and Oceanic Physics · Physics 2022-01-26 Stuart Patching

Discrete models usually represent approximations to continuum physics. Cylindrical consistency provides a framework in which discretizations mirror exactly the continuum limit. Being a standard tool for the kinematics of loop quantum…

General Relativity and Quantum Cosmology · Physics 2015-06-05 Bianca Dittrich

Simulating nonlinear classical dynamics on a quantum computer is an inherently challenging task due to the linear operator formulation of quantum mechanics. In this work, we provide a systematic approach to alleviate this difficulty by…

The techniques of data-driven backmapping from coarse-grained (CG) to fine-grained (FG) representation often struggle with accuracy, unstable training, and physical realism, especially when applied to complex systems such as proteins. In…

Machine Learning · Computer Science 2025-05-26 Georgios Kementzidis , Erin Wong , John Nicholson , Ruichen Xu , Yuefan Deng

Detecting broken time-reversibility at micro- and nanoscale is often difficult when experiments offer limited state resolution. We introduce a lumping method that builds an effective semi-Markov model able to reproduce exactly the full…

Statistical Mechanics · Physics 2025-12-16 Gianluca Teza , Attilio L. Stella , Trevor GrandPre

We derive a coarse-grained description of the dynamics of a nanoparticle immersed in an isothermal simple fluid by performing a systematic coarse graining of the underlying microscopic dynamics. As coarse-grained or relevant variables we…

Mesoscale and Nanoscale Physics · Physics 2016-01-20 Pep Español , Aleksandar Donev

Enriching Brownian motion with regenerations from a fixed regeneration distribution $\mu$ at a particular regeneration rate $\kappa$ results in a Markov process that has a target distribution $\pi$ as its invariant distribution. For the…

Computation · Statistics 2024-02-22 Hector McKimm , Andi Q Wang , Murray Pollock , Christian P Robert , Gareth O Roberts

We propose a general method for simplifying master equations by eliminating from the description rapidly evolving states. The physical recipe we impose is the suppression of these states and a renormalization of the rates of all the…

Soft Condensed Matter · Physics 2008-04-20 Simone Pigolotti , Angelo Vulpiani

The ability to control complex networks is of crucial importance across a wide range of applications in natural and engineering sciences. However, issues of both theoretical and numerical nature introduce fundamental limitations to…

Systems and Control · Electrical Eng. & Systems 2023-12-13 Daniele Toller , Mirco Tribastone , Max Tschaikowski , Andrea Vandin

Energy transport equations are derived directly from full molecular dynamics models as coarse-grained description. With the local energy chosen as the coarse-grained variables, we apply the Mori-Zwanzig formalism to derive a reduced model,…

Statistical Mechanics · Physics 2017-09-19 Weiqi Chu , Xiantao Li

In recent years, a few multiple-resolution modelling strategies have been proposed, in which functionally relevant parts of a biomolecule are described with atomistic resolution, while the remainder of the system is concurrently treated…

Soft Condensed Matter · Physics 2023-01-20 Raffaele Fiorentini , Thomas Tarenzi , Raffaello Potestio

Grain growth in nanocrystalline Al was studied by means of molecular dynamics simulations. The novelty of this study results from the utilization of an algorithm to resolve per-grain kinetics and orientation change from molecular dynamics…

Materials Science · Physics 2016-12-30 Paul W. Hoffrogge , Luis A. Barrales-Mora

Quantum stochastic processes are widely used in describing open quantum systems and in the context of quantum foundations. Physically relevant quantum stochastic processes driven by multiplicative colored noise are generically non-Markovian…

Quantum Physics · Physics 2026-03-12 Aritro Mukherjee

Accurately predicting the long-term behavior of chaotic systems is crucial for various applications such as climate modeling. However, achieving such predictions typically requires iterative computations over a dense spatiotemporal grid to…

Machine Learning · Computer Science 2025-08-01 Chuwei Wang , Julius Berner , Zongyi Li , Di Zhou , Jiayun Wang , Jane Bae , Anima Anandkumar

In many time-dependent problems of practical interest the parameters entering the equations describing the evolution of the various quantities exhibit uncertainty. One way to address the problem of how this uncertainty impacts the solution…

Numerical Analysis · Mathematics 2012-11-20 Panagiotis Stinis