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Monte Carlo methods, Variational Inference, and their combinations play a pivotal role in sampling from intractable probability distributions. However, current studies lack a unified evaluation framework, relying on disparate performance…

Machine Learning · Computer Science 2024-06-12 Denis Blessing , Xiaogang Jia , Johannes Esslinger , Francisco Vargas , Gerhard Neumann

Understanding protein conformational dynamics is essential for elucidating biological function but remains challenging due to the wide range of timescales and the complexity of collective motions. Enhanced sampling methods overcome…

Statistical Mechanics · Physics 2026-05-11 Souvik Mondal , Michael A. Sauer , Matthias Heyden

Incorporation of machine learning (ML) techniques into atomic-scale modeling has proven to be an extremely effective strategy to improve the accuracy and reduce the computational cost of simulations. It also entails conceptual and practical…

Finding proper collective variables for complex systems and processes is one of the most challenging tasks in simulations, which limits the interpretation of experimental and simulated data and the application of enhanced sampling…

We introduce a method for elucidating and modifying the functionality of systems dominated by rare events that relies on the automated tuning of their underlying free energy surface. The proposed approach seeks to construct collective…

Computational Physics · Physics 2021-08-31 Dan Mendels , Juan J. de Pablo

Mixed-integer linear programming (MILP) has been a fundamental problem in combinatorial optimization. Conventional MILP solving mainly relies on carefully designed heuristics embedded in the branch-and-bound framework. Driven by the strong…

Artificial Intelligence · Computer Science 2026-01-13 Siyuan Li , Yifan Yu , Zhihao Zhang , Mengjing Chen , Fangzhou Zhu , Tao Zhong , Peng Liu , Jianye Hao

Multimodal Large Language Models (MLLMs) show impressive vision-language benchmark performance, yet growing concerns about data contamination (test set exposure during training) risk masking true generalization. This concern extends to…

Artificial Intelligence · Computer Science 2025-06-10 Ming Liu , Wensheng Zhang

Identifying statistical regularities in solutions to some tasks in multi-task reinforcement learning can accelerate the learning of new tasks. Skill learning offers one way of identifying these regularities by decomposing pre-collected…

Machine Learning · Computer Science 2022-12-12 Yiding Jiang , Evan Zheran Liu , Benjamin Eysenbach , Zico Kolter , Chelsea Finn

Multi-task learning (MTL) is a learning paradigm that enables the simultaneous training of multiple communicating algorithms. Although MTL has been successfully applied to ether regression or classification tasks alone, incorporating mixed…

Machine Learning · Computer Science 2024-05-17 Han Cao , Sivanesan Rajan , Bianka Hahn , Ersoy Kocak , Daniel Durstewitz , Emanuel Schwarz , Verena Schneider-Lindner

MLMOD is a software package for incorporating machine learning approaches and models into simulations of microscale mechanics and molecular dynamics in LAMMPS. Recent machine learning approaches provide promising data-driven approaches for…

Machine Learning · Computer Science 2023-10-24 Paul J. Atzberger

Meta-learning (a.k.a. learning to learn) has recently emerged as a promising paradigm for a variety of applications. There are now many meta-learning methods, each focusing on different modeling aspects of base and meta learners, but all…

Machine Learning · Computer Science 2020-09-29 Yaohua Liu , Risheng Liu

Tabular data synthesis is crucial in machine learning, yet existing general methods-primarily based on statistical or deep learning models-are highly data-dependent and often fall short in recommender systems. This limitation arises from…

Information Retrieval · Computer Science 2025-02-12 Jingtong Gao , Zhaocheng Du , Xiaopeng Li , Yichao Wang , Xiangyang Li , Huifeng Guo , Ruiming Tang , Xiangyu Zhao

Molecular dynamics simulations hold great promise for providing insight into the microscopic behavior of complex molecular systems. However, their effectiveness is often constrained by long timescales associated with rare events. Enhanced…

Computational Physics · Physics 2026-03-03 Kai Zhu , Enrico Trizio , Jintu Zhang , Renling Hu , Linlong Jiang , Tingjun Hou , Luigi Bonati

This paper introduces Evalverse, a novel library that streamlines the evaluation of Large Language Models (LLMs) by unifying disparate evaluation tools into a single, user-friendly framework. Evalverse enables individuals with limited…

Computation and Language · Computer Science 2024-10-08 Jihoo Kim , Wonho Song , Dahyun Kim , Yunsu Kim , Yungi Kim , Chanjun Park

Molecular dynamics is crucial for understanding molecular systems but its applicability is often limited by the vast timescales of rare events like protein folding. Enhanced sampling techniques overcome this by accelerating the simulation…

Machine Learning · Computer Science 2026-02-24 Seonghyun Park , Kiyoung Seong , Soojung Yang , Rafael Gómez-Bombarelli , Sungsoo Ahn

Embedded systems have proliferated in various consumer and industrial applications with the evolution of Cyber-Physical Systems and the Internet of Things. These systems are subjected to stringent constraints so that embedded software must…

Finding collective variables to describe some important coarse-grained information on physical systems, in particular metastable states, remains a key issue in molecular dynamics. Recently, machine learning techniques have been intensively…

Chemical Physics · Physics 2024-03-15 Tony Lelièvre , Thomas Pigeon , Gabriel Stoltz , Wei Zhang

Large Language Models (LLMs) equipped with external tools have demonstrated enhanced performance on complex reasoning tasks. The widespread adoption of this tool-augmented reasoning is hindered by the scarcity of domain-specific tools. For…

Computation and Language · Computer Science 2025-10-10 Murong Yue , Zhiwei Liu , Liangwei Yang , Jianguo Zhang , Zuxin Liu , Haolin Chen , Ziyu Yao , Silvio Savarese , Caiming Xiong , Shelby Heinecke , Huan Wang

Investigating processes in complex molecular systems, which are characterized by many variables, is a crucial problem in computational physics. These systems can be reduced to a few meaningful degrees of freedom known as collective…

Chemical Physics · Physics 2024-05-27 Tuğçe Gökdemir , Jakub Rydzewski

Automated analyses of the outcome of a simulation have been an important part of atomistic modeling since the early days, addressing the need of linking the behavior of individual atoms and the collective properties that are usually the…

Chemical Physics · Physics 2019-05-22 Michele Ceriotti