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Curable hydrogels have tunable properties that make them well-suited for applications in drug delivery, cell therapies, and 3D bioprinting. Advances in microfluidic droplet generation enable rapid fabrication of polymer-filled droplets.…

Fluid Dynamics · Physics 2025-12-02 Sabrina Marnoto , Avi J. Patel , Sara M. Hashmi

Most commercial microfluidic droplet generators rely on the planar flow-focusing configuration implemented in polymer or glass chips. The planar geometry, however, suffers from many limitations and drawbacks, such as the need of specific…

Fluid Dynamics · Physics 2020-12-14 Adrien Dewandre , Javier Rivero-Rodriguez , Youen Vitry , Benjamin Sobac , Benoit Scheid

Droplet microfluidics offers a versatile platform for analyzing liquid samples. Despite its potential, there is a lack of techniques that allow to reliably probe individual circulating droplets. The prospect of combining droplet…

Quantitative Methods · Quantitative Biology 2024-03-08 Marc Sulliger , Jaime Ortega Arroyo , Romain Quidant

Microfluidic chips provide unparalleled control over droplets and jets, which have advanced all natural sciences. However, microfluidic applications could be vastly expanded by increasing the per-channel throughput and directly exploiting…

Generating droplets from a continuous stream of fluid requires precise tuning of a device to find optimized control parameter conditions. It is analytically intractable to compute the necessary control parameter values of a…

Machine Learning · Computer Science 2022-01-19 Alexander E. Siemenn , Evyatar Shaulsky , Matthew Beveridge , Tonio Buonassisi , Sara M. Hashmi , Iddo Drori

Electrohydrodynamic (EHD) generation, a commonly used method in BioMEMS, plays a significant role in the pulsed-release drug delivery system for a decade. In this paper, an EHD based drug delivery system is well designed, which can be used…

Medical Physics · Physics 2012-07-18 Yi Zheng , Yuan Zhang , Junqiang Hu , Qiao Lin

In this paper we present a comprehensive study of the step-emulsification process for high-throughput production of (sub-)$\mu$m-size monodisperse droplets. The microfluidic device combines a Hele-Shaw nanofluidic cell with a step-like…

Fluid Dynamics · Physics 2014-05-15 Z. Li , A. M. Leshansky , L. M. Pismen , P. Tabeling

We report on experiments of drop impacting a hydrophobic micro-grid, of typical spacing a few tens of $\mu$m. Above a threshold in impact speed, liquid emerges to the other side, forming micro-droplets of size about that of the grid holes.…

Fluid Dynamics · Physics 2015-05-14 P. Brunet , F. Lapierre , F. Zoueshtiagh , V. Thomy , A. Merlen

We present a mesoscale representation of near-contact interactions between colliding droplets which permits to reach up to the scale of full microfluidic devices, where such droplets are produced. The method is demonstrated for the case of…

Computational Physics · Physics 2020-06-23 Andrea Montessori , Marco Lauricella , Adriano Tiribocchi , Sauro Succi

Recent progress in colloidal science has led to elaborate self-assembled structures whose complexity raises hopes for elaborating new materials. However, the throughputs are extremely low and consequently, the chance to produce materials of…

Soft Condensed Matter · Physics 2014-09-16 Bingqing Shen , Joshua Ricouvier , Mathilde Reyssat , Florent Malloggi , Patrick Tabeling

Producing food-grade soft particles with controlled structure is of interest to elucidate the structure-properties relationship in soft-particles suspensions. The aim of this work is to evaluate the ability of two elaboration processes to…

Soft Condensed Matter · Physics 2022-06-30 Alban Lacroix , Murielle Hayert , Veronique Bosc , Paul Menut

We present a microfluidic platform for two-dimensional manipulation of water droplets immersed in bulk oil-based ferrofluid. Although non-magnetic, the droplets are exclusively controlled by magnetic fields, without any pressure-driven…

Fluid Dynamics · Physics 2017-12-05 Georgios Katsikis , Alexandre Breant , Anatoly Rinberg , Manu Prakash

Engineering simple, artificial models of living cells allows synthetic biologists to study cellular functions under well-controlled conditions. Reconstituting multicellular behaviors with synthetic cell-mimics is still a challenge because…

Biomolecules · Quantitative Biology 2021-04-29 Imre Banlaki , Francois-Xavier Lehr , Henrike Niederholtmeyer

The overall traffic of droplets in a network of microfluidic channels is strongly influenced by the liquid properties of the moving droplets. In particular, the effective hydrodynamic resistance of individual droplets plays a key role in…

Fluid Dynamics · Physics 2009-04-01 Vincent Labrot , Michael Schindler , Pierre Guillot , Annie Colin , Mathieu Joanicot

Encapsulation of chemicals using polymer membranes enables to control their transport and delivery for applications such as agrochemistry or detergency. To rationalize the design of polymer capsules, it is necessary to understand how the…

Soft Condensed Matter · Physics 2018-12-18 Corentin Tregouët , Thomas Salez , Mathilde Reyssat , Cécile Monteux

In microfluidic systems, droplets undergo intricate deformations as they traverse flow-focusing junctions, posing a challenging task for accurate measurement, especially during short transit times. This study investigates the physical…

This chapter presents an overview of microfluidic devices reported in the literature, used to develop methodologies for nucleation of biomolecules, with crystal size control, and for collecting thermodynamic and kinetic data. Part I is…

Soft Condensed Matter · Physics 2025-12-16 Nadine Candoni , Romain Grossier , Stéphane Veesler

Droplet-based microfluidics has emerged as a powerful technology for the miniaturization and automation of biochemical assays. The replacement of surfactants by nanoparticles as interfacial stabilizers has gained increasing interest.…

Soft Condensed Matter · Physics 2019-06-21 Laura Andreina Chacon Orellana , Jean-Christophe Baret

We have developed a method for producing spatially stable micron-scale liquid targets of flexible shapes at kilohertz repetition rate for use in air and vacuum, by perturbing 5 and 30 \mu m diameter streams with femtosecond laser pulses and…

Fluid Dynamics · Physics 2012-12-17 Pavel Chvykov , Wise Ongg , James Easter , Bixue Hou , John Nees , Karl Krushelnick

Microgels are cross-linked, colloidal polymer networks with great potential for stimuli-response release in drug-delivery applications, as their size in the nanometer range allows them to pass human cell boundaries. For applications with…

Computational Engineering, Finance, and Science · Computer Science 2023-09-01 Luise F. Kaven , Artur M. Schweidtmann , Jan Keil , Jana Israel , Nadja Wolter , Alexander Mitsos