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Hierarchical models for regionally aggregated disease incidence data commonly involve region specific latent random effects that are modeled jointly as having a multivariate Gaussian distribution. The covariance or precision matrix…

Methodology · Statistics 2019-04-30 Abhirup Datta , Sudipto Banerjee , James S. Hodges

Bayesian networks represent relations between variables using a directed acyclic graph (DAG). Learning the DAG is an NP-hard problem and exact learning algorithms are feasible only for small sets of variables. We propose two scalable…

Machine Learning · Computer Science 2021-07-02 Pierre Gillot , Pekka Parviainen

A common theme in causal inference is learning causal relationships between observed variables, also known as causal discovery. This is usually a daunting task, given the large number of candidate causal graphs and the combinatorial nature…

Machine Learning · Statistics 2022-10-11 Romain Lopez , Jan-Christian Hütter , Jonathan K. Pritchard , Aviv Regev

Deep learning (DL) has recently drawn much attention in image analysis, natural language process, and high-dimensional medical data analysis. Under the causal direct acyclic graph (DAG) interpretation, the input variables without incoming…

Applications · Statistics 2022-03-22 Jong-Hyeon Jeong , Yichen Jia

Discovering causal structure among a set of variables is a fundamental problem in many empirical sciences. Traditional score-based casual discovery methods rely on various local heuristics to search for a Directed Acyclic Graph (DAG)…

Machine Learning · Computer Science 2020-06-09 Shengyu Zhu , Ignavier Ng , Zhitang Chen

Describing the causal relations governing a system is a fundamental task in many scientific fields, ideally addressed by experimental studies. However, obtaining data under intervention scenarios may not always be feasible, while…

Methodology · Statistics 2022-05-06 Jack Kuipers , Giusi Moffa

The recent works on causal discovery have followed a similar trend of learning partial ancestral graphs (PAGs) since observational data constrain the true causal directed acyclic graph (DAG) only up to a Markov equivalence class. This…

Machine Learning · Computer Science 2026-03-03 Tingrui Huang , Devendra Singh Dhami

Leveraging labelled data from multiple domains to enable prediction in another domain without labels is a significant, yet challenging problem. To address this problem, we introduce the framework DAPDAG (\textbf{D}omain \textbf{A}daptation…

Machine Learning · Computer Science 2022-08-03 Yanke Li , Hatt Tobias , Ioana Bica , Mihaela van der Schaar

Recently directed acyclic graph (DAG) structure learning is formulated as a constrained continuous optimization problem with continuous acyclicity constraints and was solved iteratively through subproblem optimization. To further improve…

Machine Learning · Computer Science 2021-06-15 Yue Yu , Tian Gao , Naiyu Yin , Qiang Ji

Discovering causal structures from data is a challenging inference problem of fundamental importance in all areas of science. The appealing properties of neural networks have recently led to a surge of interest in differentiable neural…

Bayesian causal discovery aims to infer the posterior distribution over causal models from observed data, quantifying epistemic uncertainty and benefiting downstream tasks. However, computational challenges arise due to joint inference over…

Machine Learning · Computer Science 2023-12-11 Yashas Annadani , Nick Pawlowski , Joel Jennings , Stefan Bauer , Cheng Zhang , Wenbo Gong

We revisit the structure learning problem for dynamic Bayesian networks and propose a method that simultaneously estimates contemporaneous (intra-slice) and time-lagged (inter-slice) relationships between variables in a time-series. Our…

Emerging single-cell technologies that integrate CRISPR-based genetic perturbations with single-cell RNA sequencing, such as Perturb-seq, have substantially advanced our understanding of gene regulation and causal influence of genes. While…

Methodology · Statistics 2026-02-03 Kwangmoon Park , Hongzhe Li

Inferring the causal relationships among a set of variables in the form of a directed acyclic graph (DAG) is an important but notoriously challenging problem. Recently, advancements in high-throughput genomic perturbation screens have…

Machine Learning · Computer Science 2025-10-03 Seong Woo Han , Daniel Duy Vo , Brielin C. Brown

Causal discovery combines data with knowledge provided by experts to learn the DAG representing the causal relationships between a given set of variables. When data are scarce, bagging is used to measure our confidence in an average DAG…

Machine Learning · Statistics 2025-11-19 Alessio Zanga , Marco Scutari , Fabio Stella

Causal processes in biomedicine may contain cycles, evolve over time or differ between populations. However, many graphical models cannot accommodate these conditions. We propose to model causation using a mixture of directed cyclic graphs…

Machine Learning · Statistics 2020-09-08 Eric V. Strobl

Discovering the causal relationship via recovering the directed acyclic graph (DAG) structure from the observed data is a well-known challenging combinatorial problem. When there are latent variables, the problem becomes even more…

Machine Learning · Statistics 2023-11-02 Yunfeng Cai , Xu Li , Minging Sun , Ping Li

Reasoning about the effect of interventions and counterfactuals is a fundamental task found throughout the data sciences. A collection of principles, algorithms, and tools has been developed for performing such tasks in the last decades…

Methodology · Statistics 2023-02-08 Tara V. Anand , Adèle H. Ribeiro , Jin Tian , Elias Bareinboim

Background: There is increasing interest in approaches for analyzing the effect of exposure mixtures on health. A key issue is how to simultaneously analyze often highly collinear components of the mixture, which can create problems such as…

Methodology · Statistics 2020-07-06 Thomas F. Webster , Marc G. Weisskopf

We study structure learning for linear Gaussian SEMs in the presence of latent confounding. Existing continuous methods excel when errors are independent, while deconfounding-first pipelines rely on pervasive factor structure or…

Machine Learning · Computer Science 2025-10-03 Samhita Pal , James O'quinn , Kaveh Aryan , Heather Pua , James P. Long , Amir Asiaee
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