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Accurate prediction of thermodynamic properties is essential in drug discovery and materials science. Molecular dynamics (MD) simulations provide a principled approach to this task, yet they typically rely on prohibitively long sequential…

Chemical Physics · Physics 2025-04-03 Juan Viguera Diez , Mathias Schreiner , Ola Engkvist , Simon Olsson

Molecular dynamics (MD) simulations underpin modern computational drug discovery, materials science, and biochemistry. Recent machine learning models provide high-fidelity MD predictions without the need to repeatedly solve quantum…

Machine Learning · Computer Science 2026-04-24 Luke Thompson , Davy Guan , Dai Shi , Slade Matthews , Junbin Gao , Andi Han

Machine-learned potential-driven molecular dynamics (MLMD) simulations are of great value in guiding the design and optimization of memory devices. Amorphous indium-tin-oxide (ITO) is widely used as transparent conducting oxide for…

Materials Science · Physics 2026-01-05 Shuaiyang Guo , Yuan Wang , Wei Zhang

Image-text contrastive pretraining has become a dominant paradigm for visual representation learning, yet existing methods often yield representations that remain partially organized by modality. We propose ITO, a framework addressing this…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Hanpeng Liu , Yaqian Li , Zidan Wang , Shuoxi Zhang , Zonglin Zhao , Zihao Bo , Rinyoichi Takezoe , Kaiwen Long , Kun He

Molecular dynamics (MD) simulation is a widely used technique to simulate molecular systems, most commonly at the all-atom resolution where equations of motion are integrated with timesteps on the order of femtoseconds…

We consider the general class of time-homogeneous stochastic dynamical systems, both discrete and continuous, and study the problem of learning a representation of the state that faithfully captures its dynamics. This is instrumental to…

Machine Learning · Computer Science 2024-03-15 Vladimir R. Kostic , Pietro Novelli , Riccardo Grazzi , Karim Lounici , Massimiliano Pontil

Continued progress in inertial confinement fusion (ICF) requires solving inverse problems relating experimental observations to simulation input parameters, followed by design optimization. However, such high-dimensional dynamic…

Computational Physics · Physics 2026-01-06 Tyler E. Maltba , Ben S. Southworth , Jeffrey R. Haack , Marc L. Klasky

This paper introduces unified models for high-dimensional factor-based Ito process, which can accommodate both continuous-time Ito diffusion and discrete-time stochastic volatility (SV) models by embedding the discrete SV model in the…

Methodology · Statistics 2020-06-23 Donggyu Kim , Xinyu Song , Yazhen Wang

We present a novel active learning algorithm, termed as iterative surrogate model optimization (ISMO), for robust and efficient numerical approximation of PDE constrained optimization problems. This algorithm is based on deep neural…

Optimization and Control · Mathematics 2020-12-30 Kjetil O. Lye , Siddhartha Mishra , Deep Ray , Praveen Chandrasekhar

Neural operators, which emerge as implicit solution operators of hidden governing equations, have recently become popular tools for learning responses of complex real-world physical systems. Nevertheless, the majority of neural operator…

Machine Learning · Computer Science 2023-01-31 Ning Liu , Yue Yu , Huaiqian You , Neeraj Tatikola

Molecular dynamics simulations are powerful tools to extract the microscopic mechanisms characterizing the properties of soft materials. We recently introduced machine learning surrogates for molecular dynamics simulations of soft materials…

Soft Condensed Matter · Physics 2021-10-29 J. C. S. Kadupitiya , Nasim Anousheh , Vikram Jadhao

Molecular dynamics is based on solving Newton's equations for many-particle systems that evolve along complex, highly fluctuating trajectories. The orbital instability and short-time complexity of Newtonian orbits is in sharp contrast to…

Chemical Physics · Physics 2017-09-19 Yuriy V. Sereda , Andrew Abi Mansour , Peter J. Ortoleva

Imitation learning (IL) is notably effective for robotic tasks where directly programming behaviors or defining optimal control costs is challenging. In this work, we address a scenario where the imitator relies solely on observed behavior…

Machine Learning · Computer Science 2024-08-20 Rishabh Agrawal , Nathan Dahlin , Rahul Jain , Ashutosh Nayyar

We establish that there are properties of quantum many-body dynamics which are efficiently learnable if we are given access to out-of-time-order correlators (OTOCs), but which require exponentially many operations in the system size if we…

Quantum Physics · Physics 2022-08-05 Jordan Cotler , Thomas Schuster , Masoud Mohseni

Extrapolation remains a grand challenge in deep neural networks across all application domains. We propose an operator learning method to solve time-dependent partial differential equations (PDEs) continuously and with extrapolation in time…

Machine Learning · Computer Science 2023-12-12 Oded Ovadia , Vivek Oommen , Adar Kahana , Ahmad Peyvan , Eli Turkel , George Em Karniadakis

Multi-Agent Reinforcement Learning involves agents that learn together in a shared environment, leading to emergent dynamics sensitive to initial conditions and parameter variations. A Dynamical Systems approach, which studies the evolution…

Multiagent Systems · Computer Science 2025-01-03 David Goll , Jobst Heitzig , Wolfram Barfuss

The dominant paradigm for power system dynamic simulation is to build system-level simulations by combining physics-based models of individual components. The sheer size of the system along with the rapid integration of inverter-based…

Systems and Control · Electrical Eng. & Systems 2024-10-24 Matthew Bossart , Jose Daniel Lara , Ciaran Roberts , Rodrigo Henriquez-Auba , Duncan Callaway , Bri-Mathias Hodge

Edge robotics involves frequent exchanges of large-volume multi-modal data. Existing methods ignore the interdependency between robotic functionalities and communication conditions, leading to excessive communication overhead. This paper…

Robotics · Computer Science 2025-10-21 Dan Guo , Xibin Jin , Shuai Wang , Zhigang Wen , Miaowen Wen , Chengzhong Xu

Molecular dynamics (MD) simulation is essential for various scientific domains but computationally expensive. Learning-based force fields have made significant progress in accelerating ab-initio MD simulation but are not fast enough for…

Machine Learning · Computer Science 2023-08-29 Xiang Fu , Tian Xie , Nathan J. Rebello , Bradley D. Olsen , Tommi Jaakkola

The goal of this paper is to investigate distributed temporal difference (TD) learning for a networked multi-agent Markov decision process. The proposed approach is based on distributed optimization algorithms, which can be interpreted as…

Machine Learning · Computer Science 2025-05-14 Han-Dong Lim , Donghwan Lee
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