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Complex diseases are caused by a multitude of factors that may differ between patients. As a result, hypothesis tests comparing all patients to all healthy controls can detect many significant variables with inconsequential effect sizes. A…

Machine Learning · Statistics 2022-05-25 Eric V. Strobl , Thomas A. Lasko

Attributing an observed outcome to its root cause is a central task in domains ranging from medical diagnosis to engineering fault diagnosis. Existing approaches either equate the root cause with a root node of the causal graph, as in…

Methodology · Statistics 2026-05-13 Zitong Lu , Zhi Geng , Wei Li , Min Xie

Root causal analysis seeks to identify the set of initial perturbations that induce an unwanted outcome. In prior work, we defined sample-specific root causes of disease using exogenous error terms that predict a diagnosis in a structural…

Machine Learning · Statistics 2022-10-28 Eric V. Strobl , Thomas A. Lasko

Structural causal models are the basic modelling unit in Pearl's causal theory; in principle they allow us to solve counterfactuals, which are at the top rung of the ladder of causation. But they often contain latent variables that limit…

Artificial Intelligence · Computer Science 2021-11-23 Marco Zaffalon , Alessandro Antonucci , Rafael Cabañas

Complex diseases are caused by a multitude of factors that may differ between patients even within the same diagnostic category. A few underlying root causes may nevertheless initiate the development of disease within each patient. We…

Machine Learning · Statistics 2023-07-10 Eric V. Strobl , Thomas A. Lasko

Identifying the underlying reason for a failing dynamic process or otherwise anomalous observation is a fundamental challenge, yet has numerous industrial applications. Identifying the failure-causing sub-system using causal inference, one…

Machine Learning · Computer Science 2024-06-13 Juliane Weilbach , Sebastian Gerwinn , Karim Barsim , Martin Fränzle

This paper describes the development of a counterfactual Root Cause Analysis diagnosis approach for an industrial multivariate time series environment. It drives the attention toward the Point of Incipient Failure, which is the moment in…

Machine Learning · Computer Science 2024-07-17 Alexandre Trilla , Rajesh Rajendran , Ossee Yiboe , Quentin Possamaï , Nenad Mijatovic , Jordi Vitrià

Causal discovery, the task of automatically constructing a causal model from data, is of major significance across the sciences. Evaluating the performance of causal discovery algorithms should ideally involve comparing the inferred models…

Artificial Intelligence · Computer Science 2021-08-26 Maxime Peyrard , Robert West

Previous work establishing completeness results for counterfactual identification has been circumscribed to the setting where the input data belongs to observational or interventional distributions (Layers 1 and 2 of Pearl's Causal…

Artificial Intelligence · Computer Science 2026-03-05 Arvind Raghavan , Elias Bareinboim

The problem of individualization is recognized as crucial in almost every field. Identifying causes of effects in specific events is likewise essential for accurate decision making. However, such estimates invoke counterfactual…

Methodology · Statistics 2021-05-04 Scott Mueller , Ang Li , Judea Pearl

The framework of Pearl's Causal Hierarchy (PCH) formalizes three types of reasoning: probabilistic (i.e. purely observational), interventional, and counterfactual, that reflect the progressive sophistication of human thought regarding…

Artificial Intelligence · Computer Science 2025-02-07 Julian Dörfler , Benito van der Zander , Markus Bläser , Maciej Liskiewicz

Algorithmic recourse aims to provide actionable recommendations to individuals to obtain a more favourable outcome from an automated decision-making system. As it involves reasoning about interventions performed in the physical world,…

Machine Learning · Statistics 2021-06-23 Julius von Kügelgen , Nikita Agarwal , Jakob Zeitler , Afsaneh Mastouri , Bernhard Schölkopf

Machine learning promises to revolutionize clinical decision making and diagnosis. In medical diagnosis a doctor aims to explain a patient's symptoms by determining the diseases \emph{causing} them. However, existing diagnostic algorithms…

Machine Learning · Statistics 2020-03-17 Jonathan G. Richens , Ciaran M. Lee , Saurabh Johri

Feature attributions are a common paradigm for model explanations due to their simplicity in assigning a single numeric score for each input feature to a model. In the actionable recourse setting, wherein the goal of the explanations is to…

Machine Learning · Computer Science 2022-05-17 Emanuele Albini , Jason Long , Danial Dervovic , Daniele Magazzeni

Causal discovery in health data faces evaluation challenges when ground truth is unknown. We address this by collaborating with experts to construct proxy ground-truth graphs, establishing benchmarks for synthetic Alzheimer's disease and…

Machine Learning · Computer Science 2026-03-18 Nitish Nagesh , Elahe Khatibi , Thomas Hughes , Mahdi Bagheri , Pratik Gajane , Amir M. Rahmani

Many researchers have voiced their support towards Pearl's counterfactual theory of causation as a stepping stone for AI/ML research's ultimate goal of intelligent systems. As in any other growing subfield, patience seems to be a virtue…

Artificial Intelligence · Computer Science 2022-12-27 Matej Zečević , Moritz Willig , Devendra Singh Dhami , Kristian Kersting

Shapley values underlie one of the most popular model-agnostic methods within explainable artificial intelligence. These values are designed to attribute the difference between a model's prediction and an average baseline to the different…

Artificial Intelligence · Computer Science 2020-11-04 Tom Heskes , Evi Sijben , Ioan Gabriel Bucur , Tom Claassen

The use of machine learning systems to support decision making in healthcare raises questions as to what extent these systems may introduce or exacerbate disparities in care for historically underrepresented and mistreated groups, due to…

Machine Learning · Computer Science 2019-07-16 Stephen Pfohl , Tony Duan , Daisy Yi Ding , Nigam H. Shah

Counterfactuals are central in causal human reasoning and the scientific discovery process. The uplift, also called conditional average treatment effect, measures the causal effect of some action, or treatment, on the outcome of an…

Machine Learning · Computer Science 2025-12-10 Théo Verhelst , Denis Mercier , Jeevan Shrestha , Gianluca Bontempi

Recent rapid advancements of machine learning have greatly enhanced the accuracy of prediction models, but most models remain "black boxes", making prediction error diagnosis challenging, especially with outliers. This lack of transparency…

Machine Learning · Statistics 2025-04-29 Hiroshi Yokoyama , Ryusei Shingaki , Kaneharu Nishino , Shohei Shimizu , Thong Pham
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