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In this work, we introduce a novel computational framework that we developed to use numerical simulations to investigate the complexity of brain tissue at a microscopic level with a detail never realised before. Directly inspired by the…

Medical Physics · Physics 2018-06-20 Marco Palombo , Daniel C. Alexander , Hui Zhang

Kinetic Monte Carlo (KMC) is a powerful method for simulation of diffusion processes in various systems. The accuracy of the method, however, relies on the extent of details used for the parameterization of the model. Migration barriers are…

Characterizing the properties and orientations of sub-voxel fiber populations, although essential to study white-matter architecture, microstructure and connectivity, remains one of the main challenges faced by the MRI microstructure…

MATI (Microstructural Analysis Toolbox for Imaging) is a versatile MATLAB-based toolbox that combines both simulation and data fitting capabilities for microstructural dMRI research. It provides a user-friendly, GUI-driven interface that…

Diffusion models have been successful on a range of conditional generation tasks including molecular design and text-to-image generation. However, these achievements have primarily depended on task-specific conditional training or…

Machine Learning · Statistics 2024-11-26 Luhuan Wu , Brian L. Trippe , Christian A. Naesseth , David M. Blei , John P. Cunningham

Recent work showed that large diffusion models can be reused as highly precise monocular depth estimators by casting depth estimation as an image-conditional image generation task. While the proposed model achieved state-of-the-art results,…

Computer Vision and Pattern Recognition · Computer Science 2026-01-23 Gonzalo Martin Garcia , Karim Knaebel , Christian Schmidt , Daan de Geus , Alexander Hermans , Bastian Leibe

Accurate MR signal simulation, including microvascular structures and water diffusion, is crucial for MRI techniques like fMRI BOLD modeling and MR vascular Fingerprinting (MRF), which use susceptibility effects on MR signals for tissue…

Diffusion transformers enable flexible generative modeling for video. However, it is still technically challenging and computationally expensive to generate high-resolution videos with rich semantics and complex motion. Similar to…

Computer Vision and Pattern Recognition · Computer Science 2024-12-16 Xunnong Xu , Mengying Cao

Diffusion models have proven to be highly effective in image and video generation; however, they encounter challenges in the correct composition of objects when generating images of varying sizes due to single-scale training data. Adapting…

Computer Vision and Pattern Recognition · Computer Science 2024-09-23 Lanqing Guo , Yingqing He , Haoxin Chen , Menghan Xia , Xiaodong Cun , Yufei Wang , Siyu Huang , Yong Zhang , Xintao Wang , Qifeng Chen , Ying Shan , Bihan Wen

Microstructure reconstruction has been an essential part of computational material engineering to reveal the relationship between microstructures and material properties. However, finding a general solution for microstructure…

Materials Science · Physics 2023-01-24 Kang-Hyun Lee , Gun Jin Yun

Complex soft tissues, for example the knee meniscus, play a crucial role in mobility and joint health, but when damaged are incredibly difficult to repair and replace. This is due to their highly hierarchical and porous nature which in turn…

Computer Vision and Pattern Recognition · Computer Science 2022-11-29 J. Waghorne , C. Howard , H. Hu , J. Pang , W. J. Peveler , L. Harris , O. Barrera

Generative models are becoming popular for the synthesis of medical images. Recently, neural diffusion models have demonstrated the potential to generate photo-realistic images of objects. However, their potential to generate medical images…

Image and Video Processing · Electrical Eng. & Systems 2022-11-03 Hazrat Ali , Shafaq Murad , Zubair Shah

Diffusion generative models have excelled at diverse image generation and reconstruction tasks across fields. A less explored avenue is their application to discriminative tasks involving regression or classification problems. The…

Cosmology and Nongalactic Astrophysics · Physics 2025-02-26 Nayantara Mudur , Carolina Cuesta-Lazaro , Douglas P. Finkbeiner

Fast and accurate prediction of optimal crystal structure, topology, and microstructures is important for accelerating the design and discovery of new materials. A challenge lies in the exorbitantly large structural and compositional space…

Objective: Cone-beam computed tomography (CBCT) provides a low-dose imaging alternative to conventional CT, but suffers from noise, scatter, and artifacts that degrade image quality. Synthetic CT (sCT) aims to translate CBCT to high-quality…

Medical Physics · Physics 2025-09-23 Alzahra Altalib , Chunhui Li , Alessandro Perelli

Spatial profiling technologies in biology, such as imaging mass cytometry (IMC) and spatial transcriptomics (ST), generate high-dimensional, multi-channel data with strong spatial alignment and complex inter-channel relationships.…

Machine Learning · Computer Science 2025-07-08 Haoran Zhang , Mingyuan Zhou , Wesley Tansey

Deep denoising models require extensive real-world training data, which is challenging to acquire. Current noise synthesis techniques struggle to accurately model complex noise distributions. We propose a novel Realistic Noise Synthesis…

Computer Vision and Pattern Recognition · Computer Science 2025-01-03 Qi Wu , Mingyan Han , Ting Jiang , Chengzhi Jiang , Jinting Luo , Man Jiang , Haoqiang Fan , Shuaicheng Liu

Diffusion models for image generation have been a subject of increasing interest due to their ability to generate diverse, high-quality images. Image generation has immense potential in medical imaging because open-source medical images are…

Computer Vision and Pattern Recognition · Computer Science 2025-02-13 Benoit Freiche , Anthony El-Khoury , Ali Nasiri-Sarvi , Mahdi S. Hosseini , Damien Garcia , Adrian Basarab , Mathieu Boily , Hassan Rivaz

We propose a novel optimization framework for computing the medial axis transform that simultaneously preserves the medial structure and ensures high medial mesh quality. The medial structure, consisting of interconnected sheets, seams, and…

Graphics · Computer Science 2025-10-14 Ningna Wang , Rui Xu , Yibo Yin , Zichun Zhong , Taku Komura , Wenping Wang , Xiaohu Guo

Scarcity of annotated data, particularly for rare or atypical morphologies, present significant challenges for cell and nuclei segmentation in computational pathology. While manual annotation is labor-intensive and costly, synthetic data…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Dominik Winter , Mai Bui , Monica Azqueta Gavaldon , Nicolas Triltsch , Marco Rosati , Nicolas Brieu