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The clinical adoption of artificial intelligence (AI) in medical imaging requires models that are both diagnostically accurate and interpretable to clinicians. While current multimodal biomedical foundation models prioritize performance,…

Despite being widely used to support clinical care, general-purpose large multimodal models (LMMs) have generally shown poor or inconclusive performance in medical image interpretation, particularly in pathology, where gigapixel images are…

Computer Vision and Pattern Recognition · Computer Science 2025-11-26 Thomas A. Buckley , Kian R. Weihrauch , Katherine Latham , Andrew Z. Zhou , Padmini A. Manrai , Arjun K. Manrai

Intraoperative pathology is pivotal to precision surgery, yet its clinical impact is constrained by diagnostic complexity and the limited availability of high-quality frozen-section data. While computational pathology has made significant…

This paper presents an in-depth survey on the use of multimodal Generative Artificial Intelligence (GenAI) and autoregressive Large Language Models (LLMs) for human motion understanding and generation, offering insights into emerging…

Computer Vision and Pattern Recognition · Computer Science 2025-06-05 Muhammad Islam , Tao Huang , Euijoon Ahn , Usman Naseem

The diagnosis of pathological images is often limited by expert availability and regional disparities, highlighting the importance of automated diagnosis using Vision-Language Models (VLMs). Traditional multimodal models typically emphasize…

Computer Vision and Pattern Recognition · Computer Science 2025-04-21 Jianyu Wu , Hao Yang , Xinhua Zeng , Guibing He , Zhiyu Chen , Zihui Li , Xiaochuan Zhang , Yangyang Ma , Run Fang , Yang Liu

Large multimodal language models (LMMs) have achieved significant success in general domains. However, due to the significant differences between medical images and text and general web content, the performance of LMMs in medical scenarios…

Computer Vision and Pattern Recognition · Computer Science 2023-06-23 Weihao Gao , Zhuo Deng , Zhiyuan Niu , Fuju Rong , Chucheng Chen , Zheng Gong , Wenze Zhang , Daimin Xiao , Fang Li , Zhenjie Cao , Zhaoyi Ma , Wenbin Wei , Lan Ma

Vision-Language Models (VLMs) are advancing computational pathology with superior visual understanding capabilities. However, current systems often reduce diagnosis to directly output conclusions without verifiable evidence-linked…

Computer Vision and Pattern Recognition · Computer Science 2026-01-30 Songhan Jiang , Fengchun Liu , Ziyue Wang , Linghan Cai , Yongbing Zhang

The scarcity of well-annotated diverse medical images is a major hurdle for developing reliable AI models in healthcare. Substantial technical advances have been made in generative foundation models for natural images. Here we develop…

Computer Vision and Pattern Recognition · Computer Science 2025-09-05 Yuanfeng Ji , Dan Lin , Xiyue Wang , Lu Zhang , Wenhui Zhou , Chongjian Ge , Ruihang Chu , Xiaoli Yang , Junhan Zhao , Junsong Chen , Xiangde Luo , Sen Yang , Jin Fang , Ping Luo , Ruijiang Li

Advancements in artificial intelligence (AI) are transforming pathology by integrat-ing large language models (LLMs) with retrieval-augmented generation (RAG) and domain-specific foundation models. This study explores the application of…

Computation and Language · Computer Science 2025-05-14 Hussien Al-Asi , Jordan P Reynolds , Shweta Agarwal , Bryan J Dangott , Aziza Nassar , Zeynettin Akkus

Pathological assessment guides lung cancer diagnosis, treatment selection, and prognostic evaluation, yet current CPath approaches rely on task-specific models for isolated objectives. Although pan-cancer foundation models offer…

Automating medical report generation from histopathology images is a critical challenge requiring effective visual representations and domain-specific knowledge. Inspired by the common practices of human experts, we propose an in-context…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Shih-Wen Liu , Hsuan-Yu Fan , Wei-Ta Chu , Fu-En Yang , Yu-Chiang Frank Wang

Multimodal large language models (MLLMs) have shown remarkable performance in vision-language tasks. However, existing MLLMs are primarily trained on generic datasets, limiting their ability to reason on domain-specific visual cues such as…

Computer Vision and Pattern Recognition · Computer Science 2025-07-15 Hatef Otroshi Shahreza , Sébastien Marcel

Deep learning is widely applied in computer-aided pathological diagnosis, which alleviates the pathologist workload and provide timely clinical analysis. However, most models generally require large-scale annotated data for training, which…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Zeyu Liu , Tianyi Zhang , Yufang He , Yunlu Feng , Yu Zhao , Guanglei Zhang

We present ViDRiP-LLaVA, the first large multimodal model (LMM) in computational pathology that integrates three distinct image scenarios, including single patch images, automatically segmented pathology video clips, and manually segmented…

Computer Vision and Pattern Recognition · Computer Science 2025-10-14 Trinh T. L. Vuong , Jin Tae Kwak

Accurate semantic segmentation for histopathology image is crucial for quantitative tissue analysis and downstream clinical modeling. Recent segmentation foundation models have improved generalization through large-scale pretraining, yet…

Computer Vision and Pattern Recognition · Computer Science 2026-01-26 Peixian Liang , Songhao Li , Shunsuke Koga , Yutong Li , Zahra Alipour , Yucheng Tang , Daguang Xu , Zhi Huang

Pathology image analysis plays a pivotal role in medical diagnosis, with deep learning techniques significantly advancing diagnostic accuracy and research. While numerous studies have been conducted to address specific pathological tasks,…

Image and Video Processing · Electrical Eng. & Systems 2025-03-31 Dankai Liao , Sicheng Chen , Nuwa Xi , Qiaochu Xue , Jieyu Li , Lingxuan Hou , Zeyu Liu , Chang Han Low , Yufeng Wu , Yiling Liu , Yanqin Jiang , Dandan Li , Shangqing Lyu

Medical large vision-language Models (Med-LVLMs) have shown promise in clinical applications but suffer from factual inaccuracies and unreliable outputs, posing risks in real-world diagnostics. While RAG has emerged as a potential solution,…

Computation and Language · Computer Science 2026-05-05 Zhe Chen , Yusheng Liao , Zhiyuan Zhu , Haolin Li , Hongcheng Liu , Yanfeng Wang , Yu Wang

Plant phenotyping increasingly relies on (semi-)automated image-based analysis workflows to improve its accuracy and scalability. However, many existing solutions remain overly complex, difficult to reimplement and maintain, and pose high…

Training AI models for computational pathology currently requires access to expensive whole-slide-image datasets, GPU infrastructure, deep expertise in machine learning, and substantial engineering effort. We present CellDX AI Autopilot, a…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Alexey Pchelnikov , Aleksei Pchelnikov

The microscopic examination of surgical tissue remains a cornerstone of disease classification but relies on subjective interpretations and access to highly specialized experts, which can compromise accuracy and clinical care. While…

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