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Immunohistochemistry is a valuable diagnostic tool for cancer pathology. However, it requires specialist labs and equipment, is time-intensive, and is difficult to reproduce. Consequently, a long term aim is to provide a digital method of…

Image and Video Processing · Electrical Eng. & Systems 2022-04-15 Christopher D. Walsh , Joanne Edwards , Robert H. Insall

The overexpression of the human epidermal growth factor receptor 2 (HER2) in breast cells is a key driver of HER2-positive breast cancer, a highly aggressive subtype requiring precise diagnosis and targeted therapy. Immunohistochemistry…

Image and Video Processing · Electrical Eng. & Systems 2026-03-10 Sara Rehmat , Hafeez Ur Rehman , Byeong-Gwon Kang , Sarra Ayouni , Yunyoung Nam

Stains are essential in histopathology to visualize specific tissue characteristics, with Haematoxylin and Eosin (H&E) serving as the clinical standard. However, pathologists frequently utilize a variety of special stains for the diagnosis…

Computer Vision and Pattern Recognition · Computer Science 2026-02-11 Oskar Thaeter , Christian Grashei , Anette Haas , Elisa Schmoeckel , Han Li , Peter J. Schüffler

The presence and density of specific types of immune cells are important to understand a patient's immune response to cancer. However, immunofluorescence staining required to identify T cell subtypes is expensive, time-consuming, and rarely…

Computer Vision and Pattern Recognition · Computer Science 2022-10-18 Georg Wölflein , In Hwa Um , David J Harrison , Ognjen Arandjelović

Different types of staining highlight different structures in organs, thereby assisting in diagnosis. However, due to the impossibility of repeated staining, we cannot obtain different types of stained slides of the same tissue area.…

Image and Video Processing · Electrical Eng. & Systems 2024-04-17 Zexin Li , Yiyang Lin , Zijie Fang , Shuyan Li , Xiu Li

Generative models are widely employed to enhance the photorealism of visual synthetic data for training computer vision algorithms. However, they often introduce visual artifacts that degrade the accuracy of these algorithms and require…

Computer Vision and Pattern Recognition · Computer Science 2026-03-19 Stefanos Pasios , Nikos Nikolaidis

New medical datasets are now more open to the public, allowing for better and more extensive research. Although prepared with the utmost care, new datasets might still be a source of spurious correlations that affect the learning process.…

Image and Video Processing · Electrical Eng. & Systems 2022-09-23 Agnieszka Mikołajczyk , Sylwia Majchrowska , Sandra Carrasco Limeros

Accurate histopathological diagnosis often requires multiple differently stained tissue sections, a process that is time-consuming, labor-intensive, and environmentally taxing due to the use of multiple chemical stains. Recently, virtual…

Computer Vision and Pattern Recognition · Computer Science 2025-09-18 Jiabo MA , Wenqiang Li , Jinbang Li , Ziyi Liu , Linshan Wu , Fengtao Zhou , Li Liang , Ronald Cheong Kin Chan , Terence T. W. Wong , Hao Chen

Recent advancements in Low-Light Image Enhancement (LLIE) have focused heavily on Diffusion Probabilistic Models, which achieve high perceptual quality but suffer from significant computational latency (often exceeding 2-4 seconds per…

Computer Vision and Pattern Recognition · Computer Science 2026-01-13 Yash Thesia , Meera Suthar

The advent of Generative Adversarial Networks (GANs) has brought about completely novel ways of transforming and manipulating pixels in digital images. GAN based techniques such as Image-to-Image translations, DeepFakes, and other automated…

Computer Vision and Pattern Recognition · Computer Science 2019-10-04 Lakshmanan Nataraj , Tajuddin Manhar Mohammed , Shivkumar Chandrasekaran , Arjuna Flenner , Jawadul H. Bappy , Amit K. Roy-Chowdhury , B. S. Manjunath

Skin cancer is a serious condition that requires accurate diagnosis and treatment. One way to assist clinicians in this task is using computer-aided diagnosis (CAD) tools that automatically segment skin lesions from dermoscopic images. We…

Image and Video Processing · Electrical Eng. & Systems 2023-08-01 Shubham Innani , Prasad Dutande , Ujjwal Baid , Venu Pokuri , Spyridon Bakas , Sanjay Talbar , Bhakti Baheti , Sharath Chandra Guntuku

Three-dimensional X-ray histology techniques offer a non-invasive alternative to conventional 2D histology, enabling volumetric imaging of biological tissues without the need for physical sectioning or chemical staining. However, the…

Image and Video Processing · Electrical Eng. & Systems 2025-09-12 Sarah C. Irvine , Christian Lucas , Diana Krüger , Bianca Guedert , Julian Moosmann , Berit Zeller-Plumhoff

Generative Adversarial Networks (GANs) have been at the forefront of image synthesis, especially in medical fields like histopathology, where they help address challenges such as data scarcity, patient privacy, and class imbalance. However,…

Image and Video Processing · Electrical Eng. & Systems 2024-10-30 Osama Mustafa

Modern histopathology relies on the microscopic examination of thin tissue sections stained with histochemical techniques, typically using brightfield or fluorescence microscopy. However, the staining of samples can permanently alter their…

The development of generative models in the past decade has allowed for hyperrealistic data synthesis. While potentially beneficial, this synthetic data generation process has been relatively underexplored in cancer histopathology. One…

Image and Video Processing · Electrical Eng. & Systems 2024-12-10 Aakash Madhav Rao , Debayan Gupta

One of the biggest issues facing the use of machine learning in medical imaging is the lack of availability of large, labelled datasets. The annotation of medical images is not only expensive and time consuming but also highly dependent on…

Generative adversarial networks (GANs) are a machine learning technique capable of producing high-quality synthetic images. In the field of materials science, when a crystallographic dataset includes inadequate or difficult-to-obtain…

It is common but challenging to address high-resolution image blending in the automatic photo editing application. In this paper, we would like to focus on solving the problem of high-resolution image blending, where the composite images…

Computer Vision and Pattern Recognition · Computer Science 2019-08-06 Huikai Wu , Shuai Zheng , Junge Zhang , Kaiqi Huang

We show that pre-trained Generative Adversarial Networks (GANs) such as StyleGAN and BigGAN can be used as a latent bank to improve the performance of image super-resolution. While most existing perceptual-oriented approaches attempt to…

Computer Vision and Pattern Recognition · Computer Science 2022-08-01 Kelvin C. K. Chan , Xiangyu Xu , Xintao Wang , Jinwei Gu , Chen Change Loy

Generative Adversarial Networks (GANs) have been shown to produce realistically looking synthetic images with remarkable success, yet their performance seems less impressive when the training set is highly diverse. In order to provide a…

Machine Learning · Computer Science 2018-08-31 Matan Ben-Yosef , Daphna Weinshall