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Drug Discovery is a fundamental and ever-evolving field of research. The design of new candidate molecules requires large amounts of time and money, and computational methods are being increasingly employed to cut these costs. Machine…

Machine Learning · Statistics 2021-05-28 Pietro Bongini , Monica Bianchini , Franco Scarselli

Sensor fusion can significantly improve the performance of many computer vision tasks. However, traditional fusion approaches are either not data-driven and cannot exploit prior knowledge nor find regularities in a given dataset or they are…

Computer Vision and Pattern Recognition · Computer Science 2022-09-26 Fabian Duffhauss , Ngo Anh Vien , Hanna Ziesche , Gerhard Neumann

Designing molecules with desirable physiochemical properties and functionalities is a long-standing challenge in chemistry, material science, and drug discovery. Recently, machine learning-based generative models have emerged as promising…

Biomolecules · Quantitative Biology 2023-04-26 Zaixi Zhang , Qi Liu , Chee-Kong Lee , Chang-Yu Hsieh , Enhong Chen

In recent years the scientific community has devoted much effort in the development of deep learning models for the generation of new molecules with desirable properties (i.e. drugs). This has produced many proposals in literature. However,…

Machine Learning · Computer Science 2020-08-24 Davide Rigoni , Nicolò Navarin , Alessandro Sperduti

Although the Conditional Variational AutoEncoder (CVAE) model can generate more diversified responses than the traditional Seq2Seq model, the responses often have low relevance with the input words or are illogical with the question. A…

Computation and Language · Computer Science 2022-10-12 Jiayi Liu , Wei Wei , Zhixuan Chu , Xing Gao , Ji Zhang , Tan Yan , Yulin Kang

This study uses a Variational Autoencoder method to enhance the efficiency and applicability of Markov Chain Monte Carlo (McMC) methods by generating broader-spectrum prior proposals. Traditional approaches, such as the Karhunen-Lo\`eve…

Machine Learning · Computer Science 2025-07-02 Marcio Borges , Felipe Pereira , Michel Tosin

Variational Autoencoders (VAEs) provide a theoretically-backed and popular framework for deep generative models. However, learning a VAE from data poses still unanswered theoretical questions and considerable practical challenges. In this…

Machine Learning · Computer Science 2020-06-01 Partha Ghosh , Mehdi S. M. Sajjadi , Antonio Vergari , Michael Black , Bernhard Schölkopf

Learning network representations is a fundamental task for many graph applications such as link prediction, node classification, graph clustering, and graph visualization. Many real-world networks are interpreted as dynamic networks and…

Machine Learning · Computer Science 2019-10-07 Sedigheh Mahdavi , Shima Khoshraftar , Aijun An

Graph clustering, aiming to partition nodes of a graph into various groups via an unsupervised approach, is an attractive topic in recent years. To improve the representative ability, several graph auto-encoder (GAE) models, which are based…

Machine Learning · Computer Science 2021-03-16 Hongyuan Zhang , Rui Zhang , Xuelong Li

Generating novel molecules with optimal properties is a crucial step in many industries such as drug discovery. Recently, deep generative models have shown a promising way of performing de-novo molecular design. Although graph generative…

Machine Learning · Computer Science 2018-11-27 Rim Assouel , Mohamed Ahmed , Marwin H Segler , Amir Saffari , Yoshua Bengio

Link prediction is one of the key problems for graph-structured data. With the advancement of graph neural networks, graph autoencoders (GAEs) and variational graph autoencoders (VGAEs) have been proposed to learn graph embeddings in an…

Machine Learning · Computer Science 2021-09-14 Seong Jin Ahn , Myoung Ho Kim

Image generative models can learn the distributions of the training data and consequently generate examples by sampling from these distributions. However, when the training dataset is corrupted with outliers, generative models will likely…

Machine Learning · Computer Science 2022-09-21 Chieh-Hsin Lai , Dongmian Zou , Gilad Lerman

Despite decades of research, understanding human manipulation activities is, and has always been, one of the most attractive and challenging research topics in computer vision and robotics. Recognition and prediction of observed human…

Computer Vision and Pattern Recognition · Computer Science 2021-10-27 Gamze Akyol , Sanem Sariel , Eren Erdal Aksoy

Despite recent successes in synthesizing faces and bedrooms, existing generative models struggle to capture more complex image types, potentially due to the oversimplification of their latent space constructions. To tackle this issue,…

Machine Learning · Computer Science 2018-03-13 Wenling Shang , Kihyuk Sohn , Yuandong Tian

The problem of accelerating drug discovery relies heavily on automatic tools to optimize precursor molecules to afford them with better biochemical properties. Our work in this paper substantially extends prior state-of-the-art on…

Chemical Physics · Physics 2019-10-22 Wengong Jin , Regina Barzilay , Tommi Jaakkola

The de novo design of drug molecules is recognized as a time-consuming and costly process, and computational approaches have been applied in each stage of the drug discovery pipeline. Variational autoencoder is one of the computer-aided…

Quantum Physics · Physics 2021-12-24 Junde Li , Swaroop Ghosh

Graph autoencoders (AE) and variational autoencoders (VAE) are powerful node embedding methods, but suffer from scalability issues. In this paper, we introduce FastGAE, a general framework to scale graph AE and VAE to large graphs with…

Machine Learning · Computer Science 2021-04-14 Guillaume Salha , Romain Hennequin , Jean-Baptiste Remy , Manuel Moussallam , Michalis Vazirgiannis

Semi-supervised learning is sought for leveraging the unlabelled data when labelled data is difficult or expensive to acquire. Deep generative models (e.g., Variational Autoencoder (VAE)) and semisupervised Generative Adversarial Networks…

Machine Learning · Computer Science 2019-05-09 Xiang Zhang , Lina Yao , Feng Yuan

Variational Auto-Encoders (VAEs) have been widely applied for learning compact, low-dimensional latent representations of high-dimensional data. When the correlation structure among data points is available, previous work proposed…

Machine Learning · Computer Science 2019-12-20 Da Tang , Dawen Liang , Nicholas Ruozzi , Tony Jebara

Variational autoencdoers (VAE) are a popular approach to generative modelling. However, exploiting the capabilities of VAEs in practice can be difficult. Recent work on regularised and entropic autoencoders have begun to explore the…

Machine Learning · Computer Science 2022-03-02 Gregory A. Daly , Jonathan E. Fieldsend , Gavin Tabor