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The availability of a large amount of electronic health records (EHR) provides huge opportunities to improve health care service by mining these data. One important application is clinical endpoint prediction, which aims to predict whether…

Artificial Intelligence · Computer Science 2018-11-20 Luchen Liu , Jianhao Shen , Ming Zhang , Zichang Wang , Jian Tang

Differentiable programming has recently received much interest as a paradigm that facilitates taking gradients of computer programs. While the corresponding flexible gradient-based optimization approaches so far have been used predominantly…

Deep neural network models represent the state-of-the-art methodologies for natural language processing. Here we build on top of these methodologies to incorporate temporal information and model how to review data changes with time.…

Machine Learning · Computer Science 2020-12-11 Kostadin Cvejoski , Ramses J. Sanchez , Bogdan Georgiev , Christian Bauckhage , Cesar Ojeda

Predicting potential outcomes of interventions from observational data is crucial for decision-making in medicine, but the task is challenging due to the fundamental problem of causal inference. Existing methods are largely limited to point…

Machine Learning · Computer Science 2024-10-14 Yuchen Ma , Valentyn Melnychuk , Jonas Schweisthal , Stefan Feuerriegel

Cause-effect analysis is crucial to understand the underlying mechanism of a system. We propose to exploit model invariance through interventions on the predictors to infer causality in nonlinear multivariate systems of time series. We…

Machine Learning · Computer Science 2022-07-12 Wasim Ahmad , Maha Shadaydeh , Joachim Denzler

In prevalent cohort studies with follow-up, the time-to-event outcome is subject to left truncation leading to selection bias. For estimation of the distribution of time-to-event, conventional methods adjusting for left truncation tend to…

Methodology · Statistics 2025-12-29 Yuyao Wang , Andrew Ying , Ronghui Xu

We introduce a unified and computationally efficient framework for regression on network data, addressing limitations of existing models that require specialized estimation procedures or impose restrictive decay assumptions. Our Network…

Methodology · Statistics 2026-01-16 Yingying Ma , Chenlei Leng

As advertisers increasingly shift their budgets toward digital advertising, accurately forecasting advertising costs becomes essential for optimizing marketing campaign returns. This paper presents a comprehensive study that employs various…

Machine Learning · Computer Science 2024-08-22 Fynn Oldenburg , Qiwei Han , Maximilian Kaiser

Clinical outcome or severity prediction from medical images has largely focused on learning representations from single-timepoint or snapshot scans. It has been shown that disease progression can be better characterized by temporal imaging.…

Image and Video Processing · Electrical Eng. & Systems 2022-04-01 Aishik Konwer , Xuan Xu , Joseph Bae , Chao Chen , Prateek Prasanna

Accurate prediction of disease trajectories is critical for early identification and timely treatment of patients at risk. Conventional methods in survival analysis are often constrained by strong parametric assumptions and limited in their…

Machine Learning · Computer Science 2018-11-28 Daniel Jarrett , Jinsung Yoon , Mihaela van der Schaar

Survival analysis, which estimates the probability of event occurrence over time from censored data, is fundamental in numerous real-world applications, particularly in high-stakes domains such as healthcare and risk assessment. Despite…

Machine Learning · Computer Science 2025-05-26 Yu Liu , Weiyao Tao , Tong Xia , Simon Knight , Tingting Zhu

Survival analysis studies and predicts the time of death, or other singular unrepeated events, based on historical data, while the true time of death for some instances is unknown. Survival trees enable the discovery of complex nonlinear…

Machine Learning · Computer Science 2024-01-10 Tim Huisman , Jacobus G. M. van der Linden , Emir Demirović

Estimating causal effects from nonexperimental data is a fundamental problem in many fields of science. A key component of this task is selecting an appropriate set of covariates for confounding adjustment to avoid bias. Most existing…

Machine Learning · Computer Science 2025-10-28 Zheng Li , Xichen Guo , Feng Xie , Yan Zeng , Hao Zhang , Zhi Geng

Recent years have seen rapid progress at the intersection between causality and machine learning. Motivated by scientific applications involving high-dimensional data, in particular in biomedicine, we propose a deep neural architecture for…

Machine Learning · Computer Science 2022-12-12 Kai Lagemann , Christian Lagemann , Bernd Taschler , Sach Mukherjee

In this work, we propose a novel deep bootstrap framework for nonparametric regression based on conditional diffusion models. Specifically, we construct a conditional diffusion model to learn the distribution of the response variable given…

Machine Learning · Statistics 2026-02-12 Jinyuan Chang , Yuling Jiao , Lican Kang , Junjie Shi

The Cox proportional hazards model is a canonical method in survival analysis for prediction of the life expectancy of a patient given clinical or genetic covariates -- it is a linear model in its original form. In recent years, several…

Machine Learning · Statistics 2022-08-23 Xuelin Yang , Louis Abraham , Sejin Kim , Petr Smirnov , Feng Ruan , Benjamin Haibe-Kains , Robert Tibshirani

We study optimal covariate balance for causal inferences from observational data when rich covariates and complex relationships necessitate flexible modeling with neural networks. Standard approaches such as propensity weighting and…

Machine Learning · Statistics 2018-02-16 Nathan Kallus

Modeling the time-series of high-dimensional, longitudinal data is important for predicting patient disease progression. However, existing neural network based approaches that learn representations of patient state, while very flexible, are…

Machine Learning · Computer Science 2021-06-21 Zeshan Hussain , Rahul G. Krishnan , David Sontag

In survival analysis, longitudinal information on the health status of a patient can be used to dynamically update the predicted probability that a patient will experience an event of interest. Traditional approaches to dynamic prediction…

Methodology · Statistics 2025-06-16 Mirko Signorelli

Application of discrete-time survival methods for continuous-time survival prediction is considered. For this purpose, a scheme for discretization of continuous-time data is proposed by considering the quantiles of the estimated event-time…

Machine Learning · Statistics 2019-10-16 Håvard Kvamme , Ørnulf Borgan