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Large Language Models (LLMs) have demonstrated promise in medical knowledge assessments, yet their practical utility in real-world clinical decision-making remains underexplored. In this study, we evaluated the performance of three…

Computation and Language · Computer Science 2025-12-30 Mengdi Chai , Ali R. Zomorrodi

The development of large language models (LLMs) has brought unprecedented possibilities for artificial intelligence (AI) based medical diagnosis. However, the application perspective of LLMs in real diagnostic scenarios is still unclear…

Computation and Language · Computer Science 2024-05-21 Zhoujian Sun , Cheng Luo , Ziyi Liu , Zhengxing Huang

Traditionally, AI research in medical diagnosis has largely centered on image analysis. While this has led to notable advancements, the absence of patient-reported symptoms continues to hinder diagnostic accuracy. To address this, we…

Computer Vision and Pattern Recognition · Computer Science 2026-01-19 K Lokesh , Abhirama Subramanyam Penamakuri , Uday Agarwal , Apoorva Challa , Shreya K Gowda , Somesh Gupta , Anand Mishra

Despite the impressive capabilities of Large Language Models (LLMs), existing Conversational Health Agents (CHAs) remain static and brittle, incapable of adaptive multi-turn reasoning, symptom clarification, or transparent decision-making.…

Computation and Language · Computer Science 2025-07-11 Xinyi Liu , Dachun Sun , Yi R. Fung , Dilek Hakkani-Tür , Tarek Abdelzaher

We propose DISC-MedLLM, a comprehensive solution that leverages Large Language Models (LLMs) to provide accurate and truthful medical response in end-to-end conversational healthcare services. To construct high-quality Supervised…

Computation and Language · Computer Science 2023-08-29 Zhijie Bao , Wei Chen , Shengze Xiao , Kuang Ren , Jiaao Wu , Cheng Zhong , Jiajie Peng , Xuanjing Huang , Zhongyu Wei

Large Language Model (LLM)-based systems present new opportunities for autonomous health monitoring in sensor-rich industrial environments. This study explores the potential of LLMs to detect and classify faults directly from sensor data,…

Artificial Intelligence · Computer Science 2025-09-30 Xian Yeow Lee , Lasitha Vidyaratne , Ahmed Farahat , Chetan Gupta

The process of matching patients with suitable clinical trials is essential for advancing medical research and providing optimal care. However, current approaches face challenges such as data standardization, ethical considerations, and a…

Computation and Language · Computer Science 2023-08-08 Jiayi Yuan , Ruixiang Tang , Xiaoqian Jiang , Xia Hu

Clinical decision support systems require models that are not only highly accurate but also equitable and sensitive to the implications of missed diagnoses. In this study, we introduce a knowledge-guided in-context learning (ICL) framework…

Machine Learning · Computer Science 2025-07-28 Fatemeh Nazary , Yashar Deldjoo , Tommaso Di Noia , Eugenio di Sciascio

Large language models (LLMs) demonstrate remarkable medical expertise, but data privacy concerns impede their direct use in healthcare environments. Although offering improved data privacy protection, domain-specific small language models…

Computation and Language · Computer Science 2024-05-17 Xinlu Zhang , Shiyang Li , Xianjun Yang , Chenxin Tian , Yao Qin , Linda Ruth Petzold

The recent progress of large language models (LLMs), including ChatGPT and GPT-4, in comprehending and responding to human instructions has been remarkable. Nevertheless, these models typically perform better in English and have not been…

Computation and Language · Computer Science 2023-04-18 Honglin Xiong , Sheng Wang , Yitao Zhu , Zihao Zhao , Yuxiao Liu , Linlin Huang , Qian Wang , Dinggang Shen

This study presents an innovative approach to the application of large language models (LLMs) in clinical decision-making, focusing on OpenAI's ChatGPT. Our approach introduces the use of contextual prompts-strategically designed to include…

Artificial Intelligence · Computer Science 2023-08-22 Fatemeh Nazary , Yashar Deldjoo , Tommaso Di Noia

Multimodal large language models (MLLMs) hold considerable promise for applications in healthcare. However, their deployment in safety-critical settings is hindered by two key limitations: (i) sensitivity to prompt design, and (ii) a…

Computer Vision and Pattern Recognition · Computer Science 2025-10-14 Anita Kriz , Elizabeth Laura Janes , Xing Shen , Tal Arbel

Large language models (LLMs) show promise in drafting responses to patient portal messages, yet their integration into clinical workflows raises various concerns, including whether they would actually save clinicians time and effort in…

Computation and Language · Computer Science 2026-01-19 Parker Seegmiller , Joseph Gatto , Sarah E. Greer , Ganza Belise Isingizwe , Rohan Ray , Timothy E. Burdick , Sarah Masud Preum

Large language models (LLMs) show promise for supporting clinical decision-making in complex fields such as rheumatology. Our evaluation shows that smaller language models (SLMs), combined with retrieval-augmented generation (RAG), achieve…

Computation and Language · Computer Science 2025-07-11 Sabine Felde , Rüdiger Buchkremer , Gamal Chehab , Christian Thielscher , Jörg HW Distler , Matthias Schneider , Jutta G. Richter

In the face of rapidly expanding online medical literature, automated systems for aggregating and summarizing information are becoming increasingly crucial for healthcare professionals and patients. Large Language Models (LLMs), with their…

Computation and Language · Computer Science 2024-03-07 Niraj Yagnik , Jay Jhaveri , Vivek Sharma , Gabriel Pila

The future of conversational agents will provide users with personalized information responses. However, a significant challenge in developing models is the lack of large-scale dialogue datasets that span multiple sessions and reflect…

Information Retrieval · Computer Science 2024-05-07 Hideaki Joko , Shubham Chatterjee , Andrew Ramsay , Arjen P. de Vries , Jeff Dalton , Faegheh Hasibi

There are two main barriers to using large language models (LLMs) in clinical reasoning. Firstly, while LLMs exhibit significant promise in Natural Language Processing (NLP) tasks, their performance in complex reasoning and planning falls…

Artificial Intelligence · Computer Science 2024-12-31 Shengxin Hong , Liang Xiao , Xin Zhang , Jianxia Chen

Large language models (LLMs) have shown remarkable performance on many tasks in different domains. However, their performance in closed-book biomedical machine reading comprehension (MRC) has not been evaluated in depth. In this work, we…

Computation and Language · Computer Science 2024-10-28 Shubham Vatsal , Ayush Singh

With the advancement of large language models, many dialogue systems are now capable of providing reasonable and informative responses to patients' medical conditions. However, when patients consult their doctor, they may experience…

Computation and Language · Computer Science 2025-06-17 Shang-Chi Tsai , Yun-Nung Chen

A significant application of Large Language Models (LLMs), like ChatGPT, is their deployment as chat agents, which respond to human inquiries across a variety of domains. While current LLMs proficiently answer general questions, they often…

Computation and Language · Computer Science 2024-04-16 Lang Cao