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Particle size is a key variable in understanding the behaviour of the particulate products that underpin much of our modern lives. Typically obtained from suspensions at rest, measuring the particle size under flowing conditions would…

Soft Condensed Matter · Physics 2021-07-22 James A Richards , Vincent A Martinez , Jochen Arlt

Differential Dynamic Microscopy (DDM) analyzes traditional real-space microscope images to extract information on sample dynamics in a way akin to light scattering, by decomposing each image in a sequence into Fourier modes, and evaluating…

Soft Condensed Matter · Physics 2017-11-10 Fabio Giavazzi , Paolo Edera , Peter J. Lu , Roberto Cerbino

We have developed a lab work module where we teach undergraduate students how to quantify the dynamics of a suspension of microscopic particles, measuring and analyzing the motion of those particles at the individual level or as a group.…

Soft Condensed Matter · Physics 2016-02-23 David Germain , Mathieu Leocmach , Thomas Gibaud

Differential dynamic microscopy (DDM) is increasingly used in the fields of soft matter physics and biophysics to extract the dynamics of microscopic objects across a range of wavevectors using optical microscopy. Standard DDM is limited to…

Soft Condensed Matter · Physics 2021-02-24 Ruilin You , Ryan McGorty

Differential dynamic microscopy (DDM) typically relies on movies containing hundreds or thousands of frames to accurately quantify motion in soft matter systems. Using movies much shorter in duration produces noisier and less accurate…

Soft Condensed Matter · Physics 2024-11-05 Gildardo Martinez , Justin Siu , Steven Dang , Dylan Gage , Emma Kao , Juan Carlos Avila , Ruilin You , Ryan McGorty

Dip-coating consists in withdrawing a substrate from a bath to coat it with a thin liquid layer. This process is well-understood for homogeneous fluids, but heterogeneities such as particles dispersed in the liquid lead to more complex…

Soft Condensed Matter · Physics 2022-03-02 Deok-Hoon Jeong , Michael Ka Ho Lee , Virgile Thiévenaz , Martin Z. Bazant , A. Sauret

We investigate the effect of particle volume fraction on the efficiency of deterministic lateral displacement (DLD) devices. DLD is a popular passive sorting technique for microfluidic applications. Yet, it has been designed for treating…

Soft Condensed Matter · Physics 2015-10-27 Rohan Vernekar , Timm Krüger

Up to date, inertial migration of particles in microflows has demonstrated a great potential for a wide range of applications. In particular, this phenomenon is used to achieve particle separation or sorting in a suspension. Recent works…

Soft Condensed Matter · Physics 2019-07-29 Tohme Tohme , Yanfeng Gao , Pascale Magaud , Lucien Baldas , Christine Lafforgue , Stéphane Colin

Microscopic dynamics reveal the origin of the bulk rheological response in complex fluids. In model systems particle motion can be tracked, but for industrially relevant samples this is often impossible. Here we adapt differential dynamic…

Soft Condensed Matter · Physics 2022-02-23 James A. Richards , Vincent A. Martinez , Jochen Arlt

We demonstrate 'differential dynamic microscopy' (DDM) for the fast, high throughput characterization of the dynamics of active particles. Specifically, we characterize the swimming speed distribution and the fraction of motile cells in…

Quantitative Methods · Quantitative Biology 2011-07-12 Laurence G. Wilson , Vincent A. Martinez , Jana Schwarz-Linek , J. Tailleur , Peter N. Pusey , Gary Bryant , Wilson C. K. Poon

We use a macromodel of a flow-driven deterministic lateral displacement (DLD) microfluidic system to investigate conditions leading to size-separation of suspended particles. This model system can be easily reconfigured to establish an…

Fluid Dynamics · Physics 2016-04-27 Siqi Du , German Drazer

The ability to separate and analyze chemical species with high resolution, sensitivity, and throughput is central to the development of microfluidics systems. Deterministic lateral displacement (DLD) is a continuous separation method based…

Fluid Dynamics · Physics 2014-04-15 Timothy J. Bowman , German Drazer , Joelle Frechette

Data-dependent metrics are powerful tools for learning the underlying structure of high-dimensional data. This article develops and analyzes a data-dependent metric known as diffusion state distance (DSD), which compares points using a…

Machine Learning · Statistics 2020-03-10 Lenore Cowen , Kapil Devkota , Xiaozhe Hu , James M. Murphy , Kaiyi Wu

Over nearly two decades, Differential Dynamic Microscopy (DDM) has become a standard technique for extracting dynamic correlation functions from time-lapse microscopy data, with applications spanning colloidal suspensions, polymer…

Soft Condensed Matter · Physics 2025-11-11 Enrico Lattuada , Fabian Krautgasser , Maxime Lavaud , Fabio Giavazzi , Roberto Cerbino

Deterministic lateral displacement (DLD) devices separate micrometer-scale particles in solution based on their size using a laminar microfluidic flow in an array of obstacles. We investigate array geometries with rational row-shift…

Optical investigations on the dynamics of dense suspensions are challenging due to reduced optical accessibility. Furthermore, the suspension particle image size can strongly deviate from the optimal particle image size for PIV…

Fluid Dynamics · Physics 2021-09-22 Sebastian Blahout , Simon R. Reinecke , Harald Kruggel-Emden , Jeanette Hussong

Particle tracking microrheology (PT-$\mu$r) exploits the thermal motion of embedded particles to probe the local mechanical properties of soft materials. Despite its appealing conceptual simplicity, PT-$\mu$r requires calibration procedures…

Soft Condensed Matter · Physics 2018-01-03 Paolo Edera , Davide Bergamini , Véronique Trappe , Fabio Giavazzi , Roberto Cerbino

Colloidal suspensions are simple model systems for the study of phase transitions. Video microscopy is capable of directly imaging the structure and dynamics of colloidal suspensions in different phases. Recent results related to…

Soft Condensed Matter · Physics 2007-05-23 Piotr Habdas , Eric R. Weeks

We present a simple solution to enhance the separation ability of deterministic lateral displacement (DLD) systems by expanding the two-dimensional nature of these devices and driving the particles into size-dependent, fully…

Soft Condensed Matter · Physics 2016-04-27 Siqi Du , German Drazer

Introduced more than fifty years ago, dynamic light scattering is routinely used to determine the size distribution of colloidal suspensions, as well as of macromolecules in solution, such as proteins, nucleic acids, and their complexes.…

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