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In this paper, we introduce the first diffusion model designed to generate complete synthetic human genotypes, which, by standard protocols, one can straightforwardly expand into full-length, DNA-level genomes. The synthetic genotypes mimic…

Computational Engineering, Finance, and Science · Computer Science 2025-01-31 Philip Kenneweg , Raghuram Dandinasivara , Xiao Luo , Barbara Hammer , Alexander Schönhuth

Recent studies have demonstrated the strong empirical performance of diffusion models on discrete sequences across domains from natural language to biological sequence generation. For example, in the protein inverse folding task,…

Generative models on discrete state-spaces have a wide range of potential applications, particularly in the domain of natural sciences. In continuous state-spaces, controllable and flexible generation of samples with desired properties has…

Machine Learning · Computer Science 2025-03-27 Hunter Nisonoff , Junhao Xiong , Stephan Allenspach , Jennifer Listgarten

Speech super-resolution (SR) is the task that restores high-resolution speech from low-resolution input. Existing models employ simulated data and constrained experimental settings, which limit generalization to real-world SR. Predictive…

Audio and Speech Processing · Electrical Eng. & Systems 2024-01-26 Heming Wang , Eric W. Healy , DeLiang Wang

Creating graphic layouts is a fundamental step in graphic designs. In this work, we present a novel generative model named LayoutDiffusion for automatic layout generation. As layout is typically represented as a sequence of discrete tokens,…

Computer Vision and Pattern Recognition · Computer Science 2023-08-16 Junyi Zhang , Jiaqi Guo , Shizhao Sun , Jian-Guang Lou , Dongmei Zhang

This paper introduces a discrete diffusion model (DDM) framework for text-aligned speech tokenization and reconstruction. By replacing the auto-regressive speech decoder with a discrete diffusion counterpart, our model achieves…

Audio and Speech Processing · Electrical Eng. & Systems 2025-09-25 Pin-Jui Ku , He Huang , Jean-Marie Lemercier , Subham Sekhar Sahoo , Zhehuai Chen , Ante Jukić

Score-based generative models (SGMs) have recently emerged as a promising class of generative models. However, a fundamental limitation is that their inference is very slow due to a need for many (e.g., 2000) iterations of sequential…

Computer Vision and Pattern Recognition · Computer Science 2022-12-06 Hengyuan Ma , Li Zhang , Xiatian Zhu , Jianfeng Feng

Score-based generative modeling (SBGM) has achieved state-of-the-art performance in image generation, with the quality of generated images being highly dependent on the design of the forward (diffusion) process. Among these, models based on…

Computational Engineering, Finance, and Science · Computer Science 2026-05-12 Sascha Holl , Jente Vandersanden , Gurprit Singh , Hans-Peter Seidel

In this paper, we address the problem of generative dataset distillation that utilizes generative models to synthesize images. The generator may produce any number of images under a preserved evaluation time. In this work, we leverage the…

Computer Vision and Pattern Recognition · Computer Science 2025-04-15 Junqiao Fan , Yunjiao Zhou , Min Chang Jordan Ren , Jianfei Yang

Inverse problems describe the process of estimating the causal factors from a set of measurements or data. Mapping of often incomplete or degraded data to parameters is ill-posed, thus data-driven iterative solutions are required, for…

Artificial Intelligence · Computer Science 2024-06-21 Weitong Zhang , Chengqi Zang , Liu Li , Sarah Cechnicka , Cheng Ouyang , Bernhard Kainz

Generating graph-structured data is a challenging problem, which requires learning the underlying distribution of graphs. Various models such as graph VAE, graph GANs, and graph diffusion models have been proposed to generate meaningful and…

Machine Learning · Computer Science 2024-04-16 Tianze Luo , Zhanfeng Mo , Sinno Jialin Pan

Diffusion models have recently emerged as a powerful framework for generative modeling. They consist of a forward process that perturbs input data with Gaussian white noise and a reverse process that learns a score function to generate…

We survey continuous-time generative modeling methods based on transporting a simple reference distribution to a data distribution via stochastic or deterministic dynamics. We present a unified framework in which diffusion models,…

Machine Learning · Computer Science 2026-05-11 Aditya Ranganath , Mukesh Singhal

Diffusion models have demonstrated remarkable synthesis quality and diversity in generating co-speech gestures. However, the computationally intensive sampling steps associated with diffusion models hinder their practicality in real-world…

Graphics · Computer Science 2025-03-24 Yongkang Cheng , Shaoli Huang , Xuelin Chen , Jifeng Ning , Mingming Gong

Recent years have witnessed significant progress in developing effective training and fast sampling techniques for diffusion models. A remarkable advancement is the use of stochastic differential equations (SDEs) and their…

Computer Vision and Pattern Recognition · Computer Science 2024-08-26 Defang Chen , Zhenyu Zhou , Jian-Ping Mei , Chunhua Shen , Chun Chen , Can Wang

Generative modeling of discrete variables is challenging yet crucial for applications in natural language processing and biological sequence design. We introduce the Shortlisting Model (SLM), a novel simplex-based diffusion model inspired…

Machine Learning · Computer Science 2025-08-26 Yuxuan Song , Zhe Zhang , Yu Pei , Jingjing Gong , Qiying Yu , Zheng Zhang , Mingxuan Wang , Hao Zhou , Jingjing Liu , Wei-Ying Ma

Despite the success of deep learning across various domains, it remains vulnerable to adversarial attacks. Although many existing adversarial attack methods achieve high success rates, they typically rely on $\ell_{p}$-norm perturbation…

Computer Vision and Pattern Recognition · Computer Science 2025-10-31 Chihan Huang , Hao Tang

Scene graphs (SGs) represent objects and their relationships as structured graphs, enabling applications in image generation, robotics, and 3D understanding. Recent work suggests that conditioning image generation on scene graphs improves…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Rajalaxmi Rajagopalan , Romit Roy Choudhury

Stochastic differential equations (SDEs) provide a natural framework for modelling intrinsic stochasticity inherent in many continuous-time physical processes. When such processes are observed in multiple individuals or experimental units,…

Computation · Statistics 2016-05-19 Gavin A. Whitaker , Andrew Golightly , Richard J. Boys , Chris Sherlock

Dataset distillation enables the training of deep neural networks with comparable performance in significantly reduced time by compressing large datasets into small and representative ones. Although the introduction of generative models has…

Machine Learning · Computer Science 2025-05-27 Mingzhuo Li , Guang Li , Jiafeng Mao , Takahiro Ogawa , Miki Haseyama
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