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Large-scale language models such as GPT-3 are excellent few-shot learners, allowing them to be controlled via natural text prompts. Recent studies report that prompt-based direct classification eliminates the need for fine-tuning but lacks…

Computation and Language · Computer Science 2021-11-19 Kang Min Yoo , Dongju Park , Jaewook Kang , Sang-Woo Lee , Woomyeong Park

Pre-trained speech language models such as HuBERT and WavLM leverage unlabeled speech data for self-supervised learning and offer powerful representations for numerous downstream tasks. Despite the success of these models, their high…

Audio and Speech Processing · Electrical Eng. & Systems 2024-06-24 Yingying Gao , Shilei Zhang , Chao Deng , Junlan Feng

Language documentation projects often involve the creation of annotated text in a format such as interlinear glossed text (IGT), which captures fine-grained morphosyntactic analyses in a morpheme-by-morpheme format. However, there are few…

Computation and Language · Computer Science 2024-11-14 Michael Ginn , Lindia Tjuatja , Taiqi He , Enora Rice , Graham Neubig , Alexis Palmer , Lori Levin

Large Language Models (LLMs) have ushered in a new wave of artificial intelligence advancements impacting every scientific field and discipline. We live in a world where most of the data around us, e.g., text, audio, and music, has a…

Signal Processing · Electrical Eng. & Systems 2025-02-11 Prateek Verma

Predicting molecular properties with data-driven methods has drawn much attention in recent years. Particularly, Graph Neural Networks (GNNs) have demonstrated remarkable success in various molecular generation and prediction tasks. In…

Quantitative Methods · Quantitative Biology 2021-10-19 Zaixi Zhang , Qi Liu , Hao Wang , Chengqiang Lu , Chee-Kong Lee

We introduce Action-GPT, a plug-and-play framework for incorporating Large Language Models (LLMs) into text-based action generation models. Action phrases in current motion capture datasets contain minimal and to-the-point information. By…

Computer Vision and Pattern Recognition · Computer Science 2023-03-08 Sai Shashank Kalakonda , Shubh Maheshwari , Ravi Kiran Sarvadevabhatla

Recently, the impressive performance of large language models (LLMs) on a wide range of tasks has attracted an increasing number of attempts to apply LLMs in drug discovery. However, molecule optimization, a critical task in the drug…

Quantitative Methods · Quantitative Biology 2024-01-22 Geyan Ye , Xibao Cai , Houtim Lai , Xing Wang , Junhong Huang , Longyue Wang , Wei Liu , Xiangxiang Zeng

Deep learning is now widely used in drug discovery, providing significant acceleration and cost reduction. As the most fundamental building block, molecular representation is essential for predicting molecular properties to enable various…

Machine Learning · Computer Science 2024-04-22 Haoqiang Guo , Sendong Zhao , Haochun Wang , Yanrui Du , Bing Qin

Recent work has demonstrated that pre-trained language models (PLMs) are zero-shot learners. However, most existing zero-shot methods involve heavy human engineering or complicated self-training pipelines, hindering their application to new…

Computation and Language · Computer Science 2022-11-24 Yu Fei , Ping Nie , Zhao Meng , Roger Wattenhofer , Mrinmaya Sachan

Precise recognition, editing, and generation of molecules are essential prerequisites for both chemists and AI systems tackling various chemical tasks. We present MolLangBench, a comprehensive benchmark designed to evaluate fundamental…

Computation and Language · Computer Science 2026-03-24 Feiyang Cai , Jiahui Bai , Tao Tang , Guijuan He , Joshua Luo , Tianyu Zhu , Srikanth Pilla , Gang Li , Ling Liu , Feng Luo

Autoregressive multimodal large language models (MLLMs) enable 3D generation but struggle to scale to high-resolution shapes due to inadequate 3D tokenizations. Compact set-based representations discard deterministic spatial ordering,…

Computer Vision and Pattern Recognition · Computer Science 2026-05-29 Yuan Li , Congyi Zhang , Xifeng Gao , Xiaohu Guo

The disruptive technology provided by large-scale pre-trained language models (LLMs) such as ChatGPT or GPT-4 has received significant attention in several application domains, often with an emphasis on high-level opportunities and…

Human-Computer Interaction · Computer Science 2023-06-27 Philippe J. Giabbanelli

We introduce G2T-LLM, a novel approach for molecule generation that uses graph-to-tree text encoding to transform graph-based molecular structures into a hierarchical text format optimized for large language models (LLMs). This encoding…

Machine Learning · Computer Science 2024-10-04 Zhaoning Yu , Xiangyang Xu , Hongyang Gao

The detailed analysis of molecular structures and properties holds great potential for drug development discovery through machine learning. Developing an emergent property in the model to understand molecules would broaden the horizons for…

The integration of molecular and natural language representations has emerged as a focal point in molecular science, with recent advancements in Language Models (LMs) demonstrating significant potential for comprehensive modeling of both…

Biomolecules · Quantitative Biology 2025-03-19 Qizhi Pei , Rui Yan , Kaiyuan Gao , Jinhua Zhu , Lijun Wu

Generative pre-trained transformer (GPT) models have shown promise in clinical entity and relation extraction tasks because of their precise extraction and contextual understanding capability. In this work, we further leverage the Unified…

Computation and Language · Computer Science 2024-07-16 Kriti Bhattarai , Inez Y. Oh , Zachary B. Abrams , Albert M. Lai

Recent advancements in the field of Natural Language Processing, particularly the development of large-scale language models that are pretrained on vast amounts of knowledge, are creating novel opportunities within the realm of Knowledge…

Computation and Language · Computer Science 2023-10-06 Anisa Rula , Jennifer D'Souza

Recently multi-lingual pre-trained language models (PLM) such as mBERT and XLM-R have achieved impressive strides in cross-lingual dense retrieval. Despite its successes, they are general-purpose PLM while the multilingual PLM tailored for…

Computation and Language · Computer Science 2025-09-08 Shunyu Zhang , Yaobo Liang , Ming Gong , Daxin Jiang , Nan Duan

SMILES is a linear representation of chemical structures which encodes the connection table, and the stereochemistry of a molecule as a line of text with a grammar structure denoting atoms, bonds, rings and chains, and this information can…

Machine Learning · Computer Science 2018-12-03 Arindam Paul , Dipendra Jha , Reda Al-Bahrani , Wei-keng Liao , Alok Choudhary , Ankit Agrawal

Long-term biomolecular dynamics are critical for understanding key evolutionary transformations in molecular systems. However, capturing these processes requires extended simulation timescales that often exceed the practical limits of…

Quantitative Methods · Quantitative Biology 2025-07-04 Wenqi Zeng , Lu Zhang , Yuan Yao