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Deep image prior (DIP) has been successfully applied to positron emission tomography (PET) image restoration, enabling represent implicit prior using only convolutional neural network architecture without training dataset, whereas the…

Medical Physics · Physics 2024-04-23 Yuya Onishi , Fumio Hashimoto , Kibo Ote , Keisuke Matsubara , Masanobu Ibaraki

Sequential whole-body 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) scans are regarded as the imaging modality of choice for the assessment of treatment response in the lymphomas because they detect treatment response when…

Image and Video Processing · Electrical Eng. & Systems 2021-06-10 Kai-Chieh Liang , Lei Bi , Ashnil Kumar , Michael Fulham , Jinman Kim

Synthetic PET images are valuable for quantitative imaging workflow development, scalable virtual imaging trials, and deep learning model training, but conventional physics-based simulation approaches are computationally intensive, limited…

Computer Vision and Pattern Recognition · Computer Science 2026-05-21 Suya Li , Kaushik Dutta , Debojyoti Pal , Jingqin Luo , Kooresh I. Shoghi

In dynamic positron emission tomography (PET) reconstruction, the importance of leveraging the temporal dependence of the data has been well appreciated. Current deep-learning solutions can be categorized in two groups in the way the…

Image and Video Processing · Electrical Eng. & Systems 2024-03-13 Yubo Ye , Huafeng Liu , Linwei Wang

Deep learning-based reconstruction of positron emission tomography(PET) data has gained increasing attention in recent years. While these methods achieve fast reconstruction,concerns remain regarding quantitative accuracy and the presence…

Positron Emission Tomography using 2-[18F]-2deoxy-D-glucose as radiotracer (FDG-PET) is currently one of the most frequently applied functional imaging methods in clinical applications. The interpretation of FDG-PET data requires…

Tissues and Organs · Quantitative Biology 2020-01-22 Michele Piana , Giacomo Caviglia , Sara Sommariva

Dynamic PET kinetic modeling increasingly demands voxelwise uncertainty quantification and robust model selection. Yet total-body PET (TB-PET) data volumes make conventional Bayesian approaches, such as per-voxel MCMC, computationally…

Applications · Statistics 2026-03-17 Qinlin Gu , Gaelle M. Emvalomenos , Evan D. Morris , Clara Grazian , Steven R. Meikle

To correct for respiratory motion in PET imaging, an interpretable and unsupervised deep learning technique, FlowNet-PET, was constructed. The network was trained to predict the optical flow between two PET frames from different breathing…

Image and Video Processing · Electrical Eng. & Systems 2022-08-04 Teaghan O'Briain , Carlos Uribe , Kwang Moo Yi , Jonas Teuwen , Ioannis Sechopoulos , Magdalena Bazalova-Carter

Historically, patient datasets have been used to develop and validate various reconstruction algorithms for PET/MRI and PET/CT. To enable such algorithm development, without the need for acquiring hundreds of patient exams, in this paper we…

Objectives: Many existing techniques for the non-invasive quantification of the blood input function in dynamic FDG-PET imaging require strong historical information or user input. The technique proposed in this work utilizes the assumption…

Medical Physics · Physics 2025-03-25 William Terrell , Mark Muzi , Bijoy Kundu

Parameter efficient transfer learning (PETL) is an emerging research spot that aims to adapt large-scale pre-trained models to downstream tasks. Recent advances have achieved great success in saving storage and computation costs. However,…

Computer Vision and Pattern Recognition · Computer Science 2023-09-13 Chunqing Ruan , Hongjian Wang

Our aim was to enhance visual quality and quantitative accuracy of dynamic positron emission tomography (PET)uptake images by improved image reconstruction, using sophisticated sparse penalty models that incorporate both 2D spatial+1D…

Computer Vision and Pattern Recognition · Computer Science 2019-06-17 Ida Häggström , Yizun Lin , Si Li , Andrzej Krol , Yuesheng Xu , C. Ross Schmidtlein

Anatomic tracing data provides detailed information on brain circuitry essential for addressing some of the common errors in diffusion MRI tractography. However, automated detection of fiber bundles on tracing data is challenging due to…

Image and Video Processing · Electrical Eng. & Systems 2022-08-09 Vaanathi Sundaresan , Julia F. Lehman , Sean Fitzgibbon , Saad Jbabdi , Suzanne N. Haber , Anastasia Yendiki

Tumor vascularity detection and quantification are of high relevance in the assessment of cancer lesions not only for disease diagnostics but for therapy considerations and monitoring. The present work addressed the quantification of…

Medical Physics · Physics 2023-05-23 Jhonalbert Aponte , Álvaro Ruiz , Jacksson Sánchez , Miguel Martín-Landrove

Fully convolutional networks (FCNs), including UNet and VNet, are widely-used network architectures for semantic segmentation in recent studies. However, conventional FCN is typically trained by the cross-entropy or Dice loss, which only…

Image and Video Processing · Electrical Eng. & Systems 2021-01-26 Kelei He , Chunfeng Lian , Ehsan Adeli , Jing Huo , Yang Gao , Bing Zhang , Junfeng Zhang , Dinggang Shen

Positron emission tomography (PET) imaging is widely used in a number of clinical applications, including cancer and Alzheimer's disease (AD) diagnosis, monitoring of disease development, and treatment effect evaluation. Statistical…

Tissues and Organs · Quantitative Biology 2025-11-07 Akhil Ambekar , Robert Zielinski , Ani Eloyan

Transfer learning has become a standard practice to mitigate the lack of labeled data in medical classification tasks. Whereas finetuning a downstream task using supervised ImageNet pretrained features is straightforward and extensively…

Computer Vision and Pattern Recognition · Computer Science 2023-11-27 Tuan Truong , Sadegh Mohammadi , Matthias Lenga

Positron Emission Tomography (PET) is a vital imaging modality widely used in clinical diagnosis and preclinical research but faces limitations in image resolution and signal-to-noise ratio due to inherent physical degradation factors.…

Image and Video Processing · Electrical Eng. & Systems 2024-11-11 Boxiao Yu , Kuang Gong

The time-consuming task of manual segmentation challenges routine systematic quantification of disease burden. Convolutional neural networks (CNNs) hold significant promise to reliably identify locations and boundaries of tumors from PET…

The objective of this study was to develop a PET tumor-segmentation framework that addresses the challenges of limited spatial resolution, high image noise, and lack of clinical training data with ground-truth tumor boundaries in PET…