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In computational pathology, whole-slide image (WSI) classification presents a formidable challenge due to its gigapixel resolution and limited fine-grained annotations. Multiple-instance learning (MIL) offers a weakly supervised solution,…

Computer Vision and Pattern Recognition · Computer Science 2024-09-06 Renao Yan , Qiehe Sun , Cheng Jin , Yiqing Liu , Yonghong He , Tian Guan , Hao Chen

With recent advances in distantly supervised (DS) relation extraction (RE), considerable attention is attracted to leverage multi-instance learning (MIL) to distill high-quality supervision from the noisy DS. Here, we go beyond label noise…

Computation and Language · Computer Science 2021-06-22 Tao Chen , Haochen Shi , Liyuan Liu , Siliang Tang , Jian Shao , Zhigang Chen , Yueting Zhuang

In computational pathology, random sampling of patches during training of Multiple Instance Learning (MIL) methods is computationally efficient and serves as a regularization strategy. Despite its promising benefits, questions concerning…

Computer Vision and Pattern Recognition · Computer Science 2024-03-11 H. Keshvarikhojasteh , J. P. W. Pluim , M. Veta

Early detection of cancers has been much explored due to its paramount importance in biomedical fields. Among different types of data used to answer this biological question, studies based on T cell receptors (TCRs) are under recent…

Machine Learning · Statistics 2022-08-10 Younghoon Kim , Tao Wang , Danyi Xiong , Xinlei Wang , Seongoh Park

Multiple Instance Learning (MIL) has become the predominant approach for classification tasks on gigapixel histopathology whole slide images (WSIs). Within the MIL framework, single WSIs (bags) are decomposed into patches (instances), with…

Computer Vision and Pattern Recognition · Computer Science 2023-03-03 Daniel Sens , Ario Sadafi , Francesco Paolo Casale , Nassir Navab , Carsten Marr

Cancer diagnosis has greatly benefited from the integration of whole-slide images (WSIs) with multiple instance learning (MIL), enabling high-resolution analysis of tissue morphology. Graph-based MIL (GNN-MIL) approaches have emerged as…

Computer Vision and Pattern Recognition · Computer Science 2025-08-27 Jongwoo Kim , Bryan Wong , Huazhu Fu , Willmer Rafell Quiñones , Youngsin Ko , Mun Yong Yi

Recently neural networks and multiple instance learning are both attractive topics in Artificial Intelligence related research fields. Deep neural networks have achieved great success in supervised learning problems, and multiple instance…

Machine Learning · Statistics 2020-04-08 Xinggang Wang , Yongluan Yan , Peng Tang , Xiang Bai , Wenyu Liu

In many pattern recognition problems, a single feature vector is not sufficient to describe an object. In multiple instance learning (MIL), objects are represented by sets (\emph{bags}) of feature vectors (\emph{instances}). This requires…

Computer Vision and Pattern Recognition · Computer Science 2018-06-22 Veronika Cheplygina , David M. J. Tax

Multiple instance learning (MIL) is a framework for weakly supervised classification, where labels are assigned to sets of instances, i.e., bags, rather than to individual data points. This paradigm has proven effective in tasks where…

Machine Learning · Computer Science 2026-03-03 Salome Kazeminia , Carsten Marr , Bastian Rieck

Single-cell datasets often lack individual cell labels, making it challenging to identify cells associated with disease. To address this, we introduce Mixture Modeling for Multiple Instance Learning (MMIL), an expectation maximization…

Quantitative Methods · Quantitative Biology 2024-06-13 Erin Craig , Timothy Keyes , Jolanda Sarno , Maxim Zaslavsky , Garry Nolan , Kara Davis , Trevor Hastie , Robert Tibshirani

Diagnosis and treatment of multiple pulmonary nodules are clinically important but challenging. Prior studies on nodule characterization use solitary-nodule approaches on multiple nodular patients, which ignores the relations between…

Image and Video Processing · Electrical Eng. & Systems 2020-07-09 Jiancheng Yang , Haoran Deng , Xiaoyang Huang , Bingbing Ni , Yi Xu

An important task at the onset of a laparoscopic cholecystectomy (LC) operation is the inspection of gallbladder (GB) to evaluate the thickness of its wall, presence of inflammation and extent of fat. Difficulty in visualization of the GB…

Computer Vision and Pattern Recognition · Computer Science 2021-07-29 C. Loukas , A. Gazis , D. Schizas

Multiple Instance Learning (MIL) and transformers are increasingly popular in histopathology Whole Slide Image (WSI) classification. However, unlike human pathologists who selectively observe specific regions of histopathology tissues under…

Computer Vision and Pattern Recognition · Computer Science 2023-07-18 Conghao Xiong , Hao Chen , Joseph J. Y. Sung , Irwin King

Multi-Instance Learning (MIL) is a recent machine learning paradigm which is immensely useful in various real-life applications, like image analysis, video anomaly detection, text classification, etc. It is well known that most of the…

Computer Vision and Pattern Recognition · Computer Science 2023-04-18 Yu-Xuan Zhang , Hua Meng , Xue-Mei Cao , Zhengchun Zhou , Mei Yang , Avik Ranjan Adhikary

Despite being resource-intensive to train, 3D convolutional neural networks (CNNs) have been the standard approach to classify CT and MRI scans. Recent work suggests that deep multiple instance learning (MIL) may be a more efficient…

Machine Learning · Computer Science 2026-04-30 Ethan Harvey , Dennis Johan Loevlie , Amir Ali Satani , Wansu Chen , David M. Kent , Michael C. Hughes

Learning with few labeled data is a key challenge for visual recognition, as deep neural networks tend to overfit using a few samples only. One of the Few-shot learning methods called metric learning addresses this challenge by first…

Computer Vision and Pattern Recognition · Computer Science 2022-03-28 Li Ke , Meng Pan , Weigao Wen , Dong Li

Digital whole slides images contain an enormous amount of information providing a strong motivation for the development of automated image analysis tools. Particularly deep neural networks show high potential with respect to various tasks…

Computer Vision and Pattern Recognition · Computer Science 2023-12-07 Michael Gadermayr , Maximilian Tschuchnig

Various multi-instance learning (MIL) based approaches have been developed and successfully applied to whole-slide pathological images (WSI). Existing MIL methods emphasize the importance of feature aggregators, but largely neglect the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Yicheng Song , Tiancheng Lin , Die Peng , Su Yang , Yi Xu

Being able to learn on weakly labeled data, and provide interpretability, are two of the main reasons why attention-based deep multiple instance learning (ABMIL) methods have become particularly popular for classification of…

Computer Vision and Pattern Recognition · Computer Science 2022-03-09 Axel Andersson , Nadezhda Koriakina , Nataša Sladoje , Joakim Lindblad

Multiple Instance Learning (MIL) methods allow for gigapixel Whole-Slide Image (WSI) analysis with only slide-level annotations. Interpretability is crucial for safely deploying such algorithms in high-stakes medical domains. Traditional…

Computer Vision and Pattern Recognition · Computer Science 2025-01-07 Susu Sun , Leslie Tessier , Frédérique Meeuwsen , Clément Grisi , Dominique van Midden , Geert Litjens , Christian F. Baumgartner