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The evaluation of the individual 'fingerprint' of a human functional connectome (FC) is becoming a promising avenue for neuroscientific research, due to its enormous potential inherent to drawing single subject inferences from functional…

Neurons and Cognition · Quantitative Biology 2018-04-13 Enrico Amico , Joaquín Goñi

Functional connectivity quantifies the statistical dependencies between the activity of brain regions, measured using neuroimaging data such as functional MRI BOLD time series. The network representation of functional connectivity, called a…

Neurons and Cognition · Quantitative Biology 2020-11-23 Benjamin Chiêm , Kausar Abbas , Enrico Amico , Duy Anh Duong-Tran , Frédéric Crevecoeur , Joaquín Goñi

Functional magnetic resonance imaging (fMRI) is a non-invasive and in-vivo imaging technique essential for measuring brain activity. Functional connectivity is used to study associations between brain regions, either while study subjects…

Applications · Statistics 2024-03-26 Kun Meng , Ani Eloyan

The analysis of non-stationary time-series data requires insight into its local and global patterns with physical interpretability. However, traditional smoothing algorithms, such as B-splines, Savitzky-Golay filtering, and Empirical Mode…

Signal Processing · Electrical Eng. & Systems 2026-02-25 Teymur Aghayev

Advances in data analysis and machine learning have revolutionized the study of brain signatures using fMRI, enabling non-invasive exploration of cognition and behavior through individual neural patterns. Functional connectivity (FC), which…

Image and Video Processing · Electrical Eng. & Systems 2025-10-31 Yashaswini , Sanjay Ghosh

Brain age prediction based on neuroimaging data could help characterize both the typical brain development and neuropsychiatric disorders. Pattern recognition models built upon functional connectivity (FC) measures derived from resting…

Computer Vision and Pattern Recognition · Computer Science 2018-01-15 Hongming Li , Theodore D. Satterthwaite , Yong Fan

Correlations in the signal observed via functional Magnetic Resonance Imaging (fMRI), are expected to reveal the interactions in the underlying neural populations through hemodynamic response. In particular, they highlight distributed set…

Applications · Statistics 2012-02-07 Gaël Varoquaux , Alexandre Gramfort , Jean Baptiste Poline , Bertrand Thirion

Functional Connectivity (FC) matrices measure the regional interactions in the brain and have been widely used in neurological brain disease classification. However, a FC matrix is neither a natural image which contains shape and texture…

Medical Physics · Physics 2020-01-10 Xiaodan Xing , Qingfeng Li , Hao Wei , Minqing Zhang , Yiqiang Zhan , Xiang Sean Zhou , Zhong Xue , Feng Shi

A central challenge in analyzing multivariate interactions within complex systems is to decompose how multiple inputs jointly determine an output. Existing approaches generally operate on observed probability distributions and can conflate…

Information Theory · Computer Science 2026-03-19 Clifford Bohm , Vincent R. Ragusa , Arend Hintze , Charles Ofria , Emily Dolson , Christoph Adami

Functional magnetic resonance imaging (fMRI) enables non-invasive brain disorder classification by capturing blood-oxygen-level-dependent (BOLD) signals. However, most existing methods rely on functional connectivity (FC) via Pearson…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Guoqi Yu , Xiaowei Hu , Angelica I. Aviles-Rivero , Anqi Qiu , Shujun Wang

Brain function emerges from coordinated activity across anatomically connected regions, where structural connectivity (SC) -- the network of white matter pathways - provides the physical substrate for functional connectivity (FC) -- the…

Neurons and Cognition · Quantitative Biology 2025-07-09 Sam Frank Kelemen , Joaquín Gõni , Sérgio Pequito , Arian Ashourvan

We propose a matrix factorization technique that decomposes the resting state fMRI (rs-fMRI) correlation matrices for a patient population into a sparse set of representative subnetworks, as modeled by rank one outer products. The…

Signal Processing · Electrical Eng. & Systems 2018-07-26 Niharika Shimona D'Souza , Mary Beth Nebel , Nicholas Wymbs , Stewart Mostofsky , Archana Venkataraman

Since anatomic MRI is presently not able to directly discern neuronal loss in Parkinson's Disease (PD), studying the associated functional connectivity (FC) changes seems a promising approach toward developing non-invasive and…

Neurons and Cognition · Quantitative Biology 2018-02-07 Liviu Badea , Mihaela Onu , Tao Wu , Adina Roceanu , Ovidiu Bajenaru

This paper studies the link between resting-state functional connectivity (FC), measured by the correlations of the fMRI BOLD time courses, and structural connectivity (SC), estimated through fiber tractography. Instead of a static analysis…

Many analyses of functional magnetic resonance imaging (fMRI) examine functional connectivity (FC), or the statistical dependencies among distant brain regions. These analyses are typically exploratory, guiding future confirmatory research.…

Applications · Statistics 2025-10-20 Kyle Stanley , Nicole Lazar , Matthew Reimherr

The cross-modal synthesis between structural magnetic resonance imaging (sMRI) and functional network connectivity (FNC) is a relatively unexplored area in medical imaging, especially with respect to schizophrenia. This study employs…

Image and Video Processing · Electrical Eng. & Systems 2023-09-18 Yuda Bi , Anees Abrol , Jing Sui , Vince Calhoun

The Theory of Functional Connections (TFC) is a functional interpolation framework founded upon the so-called constrained expression: a functional that expresses the family of all possible functions that satisfy some user-specified, linear…

Analysis of PDEs · Mathematics 2021-10-25 Carl Leake

The famous Fourier theorem states that, under some restrictions, any periodic function (or real world signal) can be obtained as a sum of sinusoids, and hence, a technique exists for decomposing a signal into its sinusoidal components. From…

Numerical Analysis · Computer Science 2008-04-24 Sossio Vergara

We construct embedded functional connectivity networks (FCN) from benchmark resting-state functional magnetic resonance imaging (rsfMRI) data acquired from patients with schizophrenia and healthy controls based on linear and nonlinear…

Neurons and Cognition · Quantitative Biology 2023-03-24 Ioannis Gallos , Evangelos Galaris , Constantinos Siettos

Aggregating multi-subject functional magnetic resonance imaging (fMRI) data is indispensable for generating valid and general inferences from patterns distributed across human brains. The disparities in anatomical structures and functional…

Machine Learning · Computer Science 2019-11-20 Weida Li , Mingxia Liu , Fang Chen , Daoqiang Zhang