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The idea of using deep-learning-based molecular generation to accelerate discovery of drug candidates has attracted extraordinary attention, and many deep generative models have been developed for automated drug design, termed molecular…

Biomolecules · Quantitative Biology 2024-05-01 Odin Zhang , Haitao Lin , Hui Zhang , Huifeng Zhao , Yufei Huang , Yuansheng Huang , Dejun Jiang , Chang-yu Hsieh , Peichen Pan , Tingjun Hou

A main challenge in mechanical design is to efficiently explore the design space while satisfying engineering constraints. This work explores the use of 3D generative models to explore the design space in the context of vehicle development,…

Computer Vision and Pattern Recognition · Computer Science 2024-10-28 Hayata Morita , Kohei Shintani , Chenyang Yuan , Frank Permenter

In differentiable neural architecture search (NAS) algorithms like DARTS, the training set used to update model weight and the validation set used to update model architectures are sampled from the same data distribution. Thus, the uncommon…

Machine Learning · Computer Science 2021-12-02 Ruisi Zhang , Youwei Liang , Sai Ashish Somayajula , Pengtao Xie

Scalable multi-agent reinforcement learning (MARL) remains a central challenge for AI. Existing population-based methods, like Policy-Space Response Oracles, PSRO, require storing explicit policy populations and constructing full payoff…

Machine Learning · Computer Science 2026-03-10 Alakh Sharma , Gaurish Trivedi , Kartikey Singh Bhandari , Yash Sinha , Dhruv Kumar , Pratik Narang , Jagat Sesh Challa

Distributed Artificial Intelligence (AI) model training over mobile edge networks encounters significant challenges due to the data and resource heterogeneity of edge devices. The former hampers the convergence rate of the global model,…

Machine Learning · Computer Science 2023-10-31 Peichun Li , Hanwen Zhang , Yuan Wu , Liping Qian , Rong Yu , Dusit Niyato , Xuemin Shen

Designing and evaluating personalized and proactive assistant agents remains challenging due to the time, cost, and ethical concerns associated with human-in-the-loop experimentation. Existing Human-Computer Interaction (HCI) methods often…

Human-Computer Interaction · Computer Science 2025-11-25 Ziyi Xuan , Yiwen Wu , Xuhai Xu , Vinod Namboodiri , Mooi Choo Chuah , Yu Yang

Generative artificial intelligence (AI) systems have transformed various industries by autonomously generating content that mimics human creativity. However, concerns about their social and economic consequences arise with widespread…

Computers and Society · Computer Science 2024-09-02 Joao Tiago Aparicio , Manuela Aparicio , Sofia Aparicio , Carlos J. Costa

A recent nature inspired optimization algorithm, Fish School Search (FSS) is applied to the finite element model (FEM) updating problem. This method is tested on a GARTEUR SM-AG19 aeroplane structure. The results of this algorithm are…

Computational Engineering, Finance, and Science · Computer Science 2013-08-13 I. Boulkabeit , L. Mthembu , T. Marwala , F. De Lima Neto

Exploration of complex high-dimensional spaces presents significant challenges in fields such as molecular discovery, process optimization, and supply chain management. Genetic Algorithms (GAs), while offering significant power for creating…

Machine Learning · Computer Science 2025-12-01 Mani Valleti , Aditya Raghavan , Sergei V. Kalinin

The GKLS generator is one of the most used testbeds for benchmarking global optimization algorithms. In this paper, we conduct both a computational analysis and the Exploratory Landscape Analysis (ELA) of the GKLS generator. We utilize both…

Neural and Evolutionary Computing · Computer Science 2023-04-19 Jakub Kudela , Martin Juricek

Deep generative models, such as Variational Autoencoders (VAEs) and Generative Adversarial Networks (GANs), have been employed widely in computational creativity research. However, such models discourage out-of-distribution generation to…

Computer Vision and Pattern Recognition · Computer Science 2022-05-27 Celia Cintas , Payel Das , Brian Quanz , Girmaw Abebe Tadesse , Skyler Speakman , Pin-Yu Chen

Design space exploration is commonly performed in embedded system, where the architecture is a complicated piece of engineering. With the current trend of many-core systems, design space exploration in general-purpose computers can no…

Hardware Architecture · Computer Science 2013-09-24 Irfan Uddin

Deep generative models have shown immense potential in generating unseen data that has properties of real data. These models learn complex data-generating distributions starting from a smaller set of latent dimensions. However, generative…

Solar and Stellar Astrophysics · Physics 2026-02-23 Subhamoy Chatterjee , Andres Munoz-Jaramillo , Anna Malanushenko

Collective risk social dilemmas (CRSD) highlight a trade-off between individual preferences and the need for all to contribute toward achieving a group objective. Problems such as climate change are in this category, and so it is critical…

Multiagent Systems · Computer Science 2025-06-09 Oliver Slumbers , Joel Z. Leibo , Marco A. Janssen

Optimizing numerical systems and mechanism design is crucial for enhancing player experience in Massively Multiplayer Online (MMO) games. Traditional optimization approaches rely on large-scale online experiments or parameter tuning over…

Artificial Intelligence · Computer Science 2025-12-03 Ran Zhang , Kun Ouyang , Tiancheng Ma , Yida Yang , Dong Fang

Generative models have recently achieved remarkable success and widespread adoption in society, yet they often struggle to generate realistic and accurate outputs. This challenge extends beyond language and vision into fields like…

Machine Learning · Computer Science 2024-12-03 Lyle Regenwetter , Giorgio Giannone , Akash Srivastava , Dan Gutfreund , Faez Ahmed

The rapid evolution of Graph Neural Networks (GNNs) has led to a growing number of new architectures as well as novel applications. However, current research focuses on proposing and evaluating specific architectural designs of GNNs, as…

Machine Learning · Computer Science 2021-07-27 Jiaxuan You , Rex Ying , Jure Leskovec

In this paper, we propose a deep evolutionary learning (DEL) process that integrates fragment-based deep generative model and multi-objective evolutionary computation for molecular design. Our approach enables (1) evolutionary operations in…

Neural and Evolutionary Computing · Computer Science 2021-02-02 Yifeng Li , Hsu Kiang Ooi , Alain Tchagang

Geospatial observations combined with computational models have become key to understanding the physical systems of our environment and enable the design of best practices to reduce societal harm. Cloud-based deployments help to scale up…

Generative Adversarial Networks (GANs) have demonstrated remarkable advancements in generative modeling; however, their training is often resource-intensive, requiring extensive computational time and hundreds of thousands of epochs. This…

Machine Learning · Computer Science 2024-10-28 Beka Modrekiladze