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We propose Riemannian Denoising Diffusion Probabilistic Models (RDDPMs) for learning distributions on submanifolds of Euclidean space that are level sets of functions, including most of the manifolds relevant to applications. Existing…

Machine Learning · Computer Science 2026-02-17 Zichen Liu , Wei Zhang , Christof Schütte , Tiejun Li

Modern biomedical image analysis using deep learning often encounters the challenge of limited annotated data. To overcome this issue, deep generative models can be employed to synthesize realistic biomedical images. In this regard, we…

Image and Video Processing · Electrical Eng. & Systems 2026-02-23 Yuli Wu , Weidong He , Dennis Eschweiler , Ningxin Dou , Zixin Fan , Shengli Mi , Peter Walter , Johannes Stegmaier

Diffusion models excel at capturing the natural design spaces of images, molecules, DNA, RNA, and protein sequences. However, rather than merely generating designs that are natural, we often aim to optimize downstream reward functions while…

Despite the recent visually-pleasing results achieved, the massive computational cost has been a long-standing flaw for diffusion probabilistic models (DPMs), which, in turn, greatly limits their applications on resource-limited platforms.…

Computer Vision and Pattern Recognition · Computer Science 2022-12-01 Xingyi Yang , Daquan Zhou , Jiashi Feng , Xinchao Wang

Diffusion Probabilistic Models stand as a critical tool in generative modelling, enabling the generation of complex data distributions. This family of generative models yields record-breaking performance in tasks such as image synthesis,…

Artificial intelligence (AI) in healthcare, especially in medical imaging, faces challenges due to data scarcity and privacy concerns. Addressing these, we introduce Med-DDPM, a diffusion model designed for 3D semantic brain MRI synthesis.…

Image and Video Processing · Electrical Eng. & Systems 2024-04-22 Zolnamar Dorjsembe , Hsing-Kuo Pao , Sodtavilan Odonchimed , Furen Xiao

Latent dynamical models are commonly used to learn the distribution of a latent dynamical process that represents a sequence of noisy data samples. However, producing samples from such models with high fidelity is challenging due to the…

Machine Learning · Computer Science 2023-08-17 Mohammad R. Rezaei

Generative models of graphs based on discrete Denoising Diffusion Probabilistic Models (DDPMs) offer a principled approach to molecular generation by systematically removing structural noise through iterative atom and bond adjustments.…

Machine Learning · Computer Science 2025-11-03 Matteo Ninniri , Marco Podda , Davide Bacciu

We present a novel generative approach based on Denoising Diffusion Models (DDMs), which produces high-quality image samples along with their losslessly compressed bit-stream representations. This is obtained by replacing the standard…

Image and Video Processing · Electrical Eng. & Systems 2025-07-29 Guy Ohayon , Hila Manor , Tomer Michaeli , Michael Elad

In this work, we propose FastDPM, a unified framework for fast sampling in diffusion probabilistic models. FastDPM generalizes previous methods and gives rise to new algorithms with improved sample quality. We systematically investigate the…

Machine Learning · Computer Science 2021-06-25 Zhifeng Kong , Wei Ping

Denoising diffusion probabilistic models (DDPMs) have been proven capable of synthesizing high-quality images with remarkable diversity when trained on large amounts of data. However, to our knowledge, few-shot image generation tasks have…

Computer Vision and Pattern Recognition · Computer Science 2023-03-08 Jingyuan Zhu , Huimin Ma , Jiansheng Chen , Jian Yuan

Discrete diffusion models offer a promising alternative to autoregressive generation through parallel decoding, but they suffer from a sampling wall: once categorical sampling occurs, rich distributional information collapses into one-hot…

Machine Learning · Computer Science 2026-05-14 Mingyu Jo , Jaesik Yoon , Justin Deschenaux , Caglar Gulcehre , Sungjin Ahn

Score-based models generate samples by mapping noise to data (and vice versa) via a high-dimensional diffusion process. We question whether it is necessary to run this entire process at high dimensionality and incur all the inconveniences…

Machine Learning · Computer Science 2023-02-28 Bowen Jing , Gabriele Corso , Renato Berlinghieri , Tommi Jaakkola

Denoising diffusion probabilistic models (DDPMs) represent an entirely new class of generative AI methods that have yet to be fully explored. They use Langevin dynamics, represented as stochastic differential equations, to describe a…

Machine Learning · Statistics 2025-10-21 Benjamin Sterling , Chad Gueli , Mónica F. Bugallo

Denoising diffusion probabilistic models (DDPMs) have recently achieved leading performances in many generative tasks. However, the inherited iterative sampling process costs hindered their applications to speech synthesis. This paper…

Audio and Speech Processing · Electrical Eng. & Systems 2022-04-22 Rongjie Huang , Max W. Y. Lam , Jun Wang , Dan Su , Dong Yu , Yi Ren , Zhou Zhao

Denoising Diffusion Probabilistic Models (DDPMs) have recently achieved remarkable results in conditional and unconditional image generation. The pre-trained models can be adapted without further training to different downstream tasks, by…

Computer Vision and Pattern Recognition · Computer Science 2023-09-19 Asya Grechka , Guillaume Couairon , Matthieu Cord

Diffusion probabilistic models (DPMs) have achieved impressive success in visual generation. While, they suffer from slow inference speed due to iterative sampling. Employing fewer sampling steps is an intuitive solution, but this will also…

Computer Vision and Pattern Recognition · Computer Science 2025-06-17 Hu Yu , Hao Luo , Fan Wang , Feng Zhao

Advances in microscopy imaging enable researchers to visualize structures at the nanoscale level thereby unraveling intricate details of biological organization. However, challenges such as image noise, photobleaching of fluorophores, and…

Image and Video Processing · Electrical Eng. & Systems 2024-09-19 Pamela Osuna-Vargas , Maren H. Wehrheim , Lucas Zinz , Johanna Rahm , Ashwin Balakrishnan , Alexandra Kaminer , Mike Heilemann , Matthias Kaschube

Free-form inpainting is the task of adding new content to an image in the regions specified by an arbitrary binary mask. Most existing approaches train for a certain distribution of masks, which limits their generalization capabilities to…

Computer Vision and Pattern Recognition · Computer Science 2022-09-01 Andreas Lugmayr , Martin Danelljan , Andres Romero , Fisher Yu , Radu Timofte , Luc Van Gool

The use of deep learning to solve problems in literary arts has been a recent trend that has gained a lot of attention and automated generation of music has been an active area. This project deals with the generation of music using raw…

Sound · Computer Science 2016-12-16 Vasanth Kalingeri , Srikanth Grandhe