English
Related papers

Related papers: Bayesian mixed model inference for genetic associa…

200 papers

Brain connectivity analysis is crucial for understanding brain structure and neurological function, shedding light on the mechanisms of mental illness. To study the association between individual brain connectivity networks and the clinical…

Converging evidence indicates that the heterogeneity of cognitive profiles may arise through detectable alternations in brain functions. Particularly, brain functional connectivity, measured under resting and cognitive states, characterizes…

Applications · Statistics 2023-02-22 Tianqi Chen , Chichun Tan , Hongyu Zhao , Todd Constable , Sarah Yip , Yize Zhao

Learning the structure of Bayesian networks from data provides insights into underlying processes and the causal relationships that generate the data, but its usefulness depends on the homogeneity of the data population, a condition often…

Studying the neurological, genetic and evolutionary basis of human vocal communication mechanisms using animal vocalization models is an important field of neuroscience. The data sets typically comprise structured sequences of syllables or…

Our interest is in multiplex network data with multiple network samples observed across the same set of nodes. Examples originate from a variety of fields, including brain connectivity, international trade networks, and social networks,…

Methodology · Statistics 2026-04-21 Yuren Zhou , Yuqi Gu , David B. Dunson

With distinct advantages in power over behavioral phenotypes, brain imaging traits have become emerging endophenotypes to dissect molecular contributions to behaviors and neuropsychiatric illnesses. Among different imaging features, brain…

Applications · Statistics 2022-12-05 Yize Zhao , Changgee Chang , Jingwen Zhang , Zhengwu Zhang

Replicated network data are increasingly available in many research fields. In connectomic applications, inter-connections among brain regions are collected for each patient under study, motivating statistical models which can flexibly…

Methodology · Statistics 2018-09-11 Daniele Durante , David B. Dunson , Joshua T. Vogelstein

In this paper, we develop a graphical modeling framework for the inference of networks across multiple sample groups and data types. In medical studies, this setting arises whenever a set of subjects, which may be heterogeneous due to…

Brain connectivity analysis based on magnetic resonance imaging is crucial for understanding neurological mechanisms. However, edge-based connectivity inference faces significant challenges, particularly the curse of dimensionality when…

Methodology · Statistics 2025-12-23 Zijing Li , Chenhao Zeng , Shufei Ge

We present a statistical framework that jointly models brain shape and functional connectivity, which are two complex aspects of the brain that have been classically studied independently. We adopt a Riemannian modeling approach to account…

Methodology · Statistics 2024-04-26 Eardi Lila , John A. D. Aston

We tackle classification based on brain connectivity derived from diffusion magnetic resonance images. We propose a machine-learning model inspired by graph convolutional networks (GCNs), which takes a brain connectivity input graph and…

Neurons and Cognition · Quantitative Biology 2023-09-21 Anees Kazi , Jocelyn Mora , Bruce Fischl , Adrian V. Dalca , Iman Aganj

Network data arises through observation of relational information between a collection of entities. Recent work in the literature has independently considered when (i) one observes a sample of networks, connectome data in neuroscience being…

Methodology · Statistics 2022-06-22 George Bolt , Simón Lunagómez , Christopher Nemeth

Motivated by genetic association studies of pleiotropy, we propose here a Bayesian latent variable approach to jointly study multiple outcomes or phenotypes. The proposed method models both continuous and binary phenotypes, and it accounts…

Applications · Statistics 2012-11-08 Lizhen Xu , Radu V. Craiu , Lei Sun

Network data are increasingly collected along with other variables of interest. Our motivation is drawn from neurophysiology studies measuring brain connectivity networks for a sample of individuals along with their membership to a low or…

Methodology · Statistics 2018-09-11 Daniele Durante , David B. Dunson

In neuroimaging data analysis, Gaussian graphical models are often used to model statistical dependencies across spatially remote brain regions known as functional connectivity. Typically, data is collected across a cohort of subjects and…

Machine Learning · Statistics 2015-12-08 Ricardo Pio Monti , Christoforos Anagnostopoulos , Giovanni Montana

Motivated by examples from genetic association studies, this paper considers the model selection problem in a general complex linear model system and in a Bayesian framework. We discuss formulating model selection problems and incorporating…

Methodology · Statistics 2014-03-14 Xiaoquan Wen

Bayesian phylogenetic inference is currently done via Markov chain Monte Carlo (MCMC) with simple proposal mechanisms. This hinders exploration efficiency and often requires long runs to deliver accurate posterior estimates. In this paper,…

Machine Learning · Statistics 2024-05-24 Cheng Zhang , Frederick A. Matsen

Although there is a rapidly growing literature on dynamic connectivity methods, the primary focus has been on separate network estimation for each individual, which fails to leverage common patterns of information. We propose novel…

Methodology · Statistics 2021-01-15 Suprateek Kundu , Jin Ming , Joe Nocera , Keith M. McGregor

This paper introduces a Bayesian framework that combines Markov chain Monte Carlo (MCMC) sampling, dimensionality reduction, and neural density estimation to efficiently handle inverse problems that (i) must be solved multiple times, and…

Computational Engineering, Finance, and Science · Computer Science 2026-02-24 Giacomo Bottacini , Matteo Torzoni , Andrea Manzoni

Brain activation and connectivity analyses in task-based functional magnetic resonance imaging (fMRI) experiments with multiple subjects are currently at the forefront of data-driven neuroscience. In such experiments, interest often lies in…

Applications · Statistics 2019-04-02 Daniel Spencer , Rajarshi Guhaniyogi , Raquel Prado