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AlphaFold has achieved groundbreaking advancements in protein structure prediction, exerting profound influence across biology, medicine, and drug discovery. However, its reliance on multiple sequence alignment (MSA) is inherently…

Quantum Physics · Physics 2025-06-03 Rong Chen , Quan-Xin Mei , Wen-Ding Zhao , Lin Yao , Hao-Xiang Yang , Shun-Yao Zhang , Jiao Chen , Hong-Lin Li

The Steiner Tree Problem (STP) is a well-known NP-hard combinatorial optimization problem, which has wide applications in network design, integrated circuit layout, bioinformatics, and other fields. However, traditional algorithms often…

Quantum Physics · Physics 2026-03-05 Dan Li , Xiang-Hui Wu , Ji-Rong Liu

With the advent of novel quantum computing technologies, and the knowledge that such technology might be used to fundamentally change computing applications, a prime opportunity has presented itself to investigate the practical application…

Computational Engineering, Finance, and Science · Computer Science 2024-02-13 Kevin Wils , Boyang Chen

The broad applicability of Quadratic Unconstrained Binary Optimization (QUBO) constitutes a general-purpose modeling framework for combinatorial optimization problems and are a required format for gate array and quantum annealing computers.…

Artificial Intelligence · Computer Science 2021-04-06 Amit Verma , Mark Lewis

Assessing cyber risk in complex IT infrastructures poses significant challenges due to the dynamic, interconnected nature of digital systems. Traditional methods often fall short, relying on static and largely qualitative models that do not…

Quantum Physics · Physics 2026-04-22 Remo Marini , Riccardo Arpe

Gaussian Processes are used in many applications to model spatial phenomena. Within this context, a key issue is to decide the set of locations where to take measurements so as to obtain a better approximation of the underlying function.…

Emerging Technologies · Computer Science 2019-01-31 Lorenzo Bottarelli , Alessandro Farinelli

The D-Wave quantum annealing machine can quickly find the optimal solution for quadratic unconstrained binary optimization (QUBO). One of the applications where the use of quantum annealing is desired is in problems requiring rapid…

Quantum Physics · Physics 2024-12-11 Reo Shikanai , Masayuki Ohzeki , Kazuyuki Tanaka

Quadratic Unconstrained Binary Optimization (QUBO) is a standard NP-hard optimization problem. Recently, it has gained renewed interest through quantum computing, as QUBOs directly reduce to the Ising model, on which quantum annealing…

Quantum Physics · Physics 2026-03-16 Katalin Friedl , Levente Gegő , László Kabódi , Viktória Nemkin

Quadratic unconstrained binary optimization problems (QUBOs) are intensively discussed in the realm of quantum computing and polynomial optimization. We provide a vast experimental study of semidefinite programming (SDP) relaxations of…

Spin defects in two-dimensional materials are a promising platform for quantum sensing. Simulating the defect's optical response and optically detected magnetic resonance (ODMR) contrast is key to identifying suitable candidates. However,…

In recent years, quantum, quantum-inspired, and hybrid algorithms are increasingly showing promise for solving software engineering optimization problems. However, best-intended practices for conducting empirical studies have not yet well…

Software Engineering · Computer Science 2025-11-03 Man Zhang , Yuechen Li , Tao Yue , Kai-Yuan Cai

Simulated annealing (SA) is a key algorithm for solving combinatorial optimization problems, which model numerous real-world systems. While SA is commonly used to solve quadratic unconstrained binary optimization (QUBO) problems, many…

Statistical Mechanics · Physics 2026-05-05 Kohei Suzuki

Solving combinatorial optimization problems of the kind that can be codified by quadratic unconstrained binary optimization (QUBO) is a promising application of quantum computation. Some problems of this class suitable for practical…

Quadratic Unconstrained Binary Optimization (QUBO) is a broad class of optimization problems with many practical applications. To solve its hard instances in an exact way, known classical algorithms require exponential time and several…

Quantum Physics · Physics 2021-01-21 Gian Giacomo Guerreschi

Phasor Measurement Units (PMUs) are essential measuring devices for monitoring, control and protection of power systems. The objective of the optimal PMU placement (OPP) problem is to minimize the number of PMUs and select the bus locations…

Optimization and Control · Mathematics 2015-08-25 Nikolaos Theodorakatos , Nikolaos Manousakis , George Korres

As consequences of disruptions in railway traffic affect passenger experience/satisfaction, appropriate rerouting and/or rescheduling is necessary. These problems are known to be NP-hard, given the numerous restrictions of traffic nature.…

Emerging Technologies · Computer Science 2022-10-06 Krzysztof Domino , Akash Kundu , Özlem Salehi , Krzysztof Krawiec

In recent years, there is a growing interest in using quantum computers for solving combinatorial optimization problems. In this work, we developed a generic, machine learning-based framework for mapping continuous-space inverse design…

The quantum approximate optimization algorithm (QAOA) is designed to determine optimum and near optimum solutions of quadratic (and higher order) unconstrained binary optimization (QUBO or HUBO) problems, which in turn accurately model…

Quantum Physics · Physics 2025-03-18 Prashanti Priya Angara , Danylo Lykov , Ulrike Stege , Yuri Alexeev , Hausi Müller

Multi-objective combinatorial optimization in wireless communication networks is a challenging task, particularly for large-scale and diverse topologies. Recent advances in quantum computing offer promising solutions for such problems.…

Quantum Physics · Physics 2025-03-12 Yu-Xuan Lin , Chu-Yao Xu , Chuan Wang

This paper investigates generic signal shaping methods for multiple-data-stream generalized spatial modulation (GenSM) and generalized quadrature spatial modulation (GenQSM) based on the maximizing the minimum Euclidean distance (MMED)…

Signal Processing · Electrical Eng. & Systems 2019-01-29 Shuaishuai Guo , Haixia Zhang , Peng Zhang , Shuping Dang , Liang Cong , Mohamed-Slim Alouini