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Transformer-based architectures have advanced medical image analysis by effectively modeling long-range dependencies, yet they often struggle in 3D settings due to substantial memory overhead and insufficient capture of fine-grained local…

Levin Tree Search (LTS) (Orseau et al., 2018) is a search algorithm for deterministic environments that uses a user-specified policy to guide the search. It comes with a formal guarantee on the number of search steps (node visits) for…

Artificial Intelligence · Computer Science 2025-03-12 Laurent Orseau , Marcus Hutter , Levi H. S. Lelis

Research increasingly relies on computational methods to analyze experimental data and predict molecular properties. Current approaches often require researchers to use a variety of tools for statistical analysis and machine learning,…

Quantitative Methods · Quantitative Biology 2025-12-01 Luke Rimmo Lego , Samantha Gauthier , Denver Jn. Baptiste

Monte Carlo Tree Search (MCTS) algorithms have achieved great success on many challenging benchmarks (e.g., Computer Go). However, they generally require a large number of rollouts, making their applications costly. Furthermore, it is also…

Machine Learning · Computer Science 2020-02-27 Anji Liu , Jianshu Chen , Mingze Yu , Yu Zhai , Xuewen Zhou , Ji Liu

Over the last couple of decades, there has been a surge in various approaches to multiple-point statistics simulation, commonly referred to as MPS. These methods have aimed to improve several critical aspects of realism in the results,…

The k-spectrum of a string is the set of all distinct substrings of length k occurring in the string. K-spectra have many applications in bioinformatics including pseudoalignment and genome assembly. The Spectral Burrows-Wheeler Transform…

Data Structures and Algorithms · Computer Science 2023-06-09 Jarno N. Alanko , Elena Biagi , Simon J. Puglisi

Vision Transformers (ViTs) and Swin Transformers (Swin) are currently state-of-the-art in computational pathology. However, domain experts are still reluctant to use these models due to their lack of interpretability. This is not…

Computer Vision and Pattern Recognition · Computer Science 2024-01-19 Manuel Tran , Amal Lahiani , Yashin Dicente Cid , Melanie Boxberg , Peter Lienemann , Christian Matek , Sophia J. Wagner , Fabian J. Theis , Eldad Klaiman , Tingying Peng

We study learning-augmented binary search trees (BSTs) via Treaps with carefully designed priorities. The result is a simple search tree in which the depth of each item $x$ is determined by its predicted weight $w_x$. Specifically, each…

Data Structures and Algorithms · Computer Science 2025-05-16 Jingbang Chen , Xinyuan Cao , Alicia Stepin , Li Chen

In this paper, we study CPU utilization time patterns of several MapReduce applications. After extracting running patterns of several applications, they are saved in a reference database to be later used to tweak system parameters to…

Distributed, Parallel, and Cluster Computing · Computer Science 2013-01-30 Nikzad Babaii Rizvandi , Javid Taheri , Albert Y. Zomaya

The merging of succinct data structures is a well established technique for the space efficient construction of large succinct indexes. In the first part of the paper we propose a new algorithm for merging succinct representations of de…

Data Structures and Algorithms · Computer Science 2021-07-13 Lavinia Egidi , Felipe A. Louza , Giovanni Manzini

Innovations in Next-Generation Sequencing are enabling generation of DNA sequence data at ever faster rates and at very low cost. Large sequencing centers typically employ hundreds of such systems. Such high-throughput and low-cost…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-07-31 Vasimuddin Md , Sanchit Misra , Heng Li , Srinivas Aluru

This paper presents a new modeling strategy for joint unsupervised analysis of multiple high-throughput biological studies. As in Multi-study Factor Analysis, our goals are to identify both common factors shared across studies and…

Applications · Statistics 2018-06-27 Roberta De Vito , Ruggero Bellio , Lorenzo Trippa , Giovanni Parmigiani

Data compression plays an important role to deal with high volumes of DNA sequences in the field of Bioinformatics. Again data compression techniques directly affect the alignment of DNA sequences. So the time needed to decompress a…

Computational Engineering, Finance, and Science · Computer Science 2012-11-13 Subhankar Roy , Sunirmal Khatua , Sudipta Roy , Samir K. Bandyopadhyay

In order to associate complex traits with genetic polymorphisms, genome-wide association studies process huge datasets involving tens of thousands of individuals genotyped for millions of polymorphisms. When handling these datasets, which…

Genomics · Quantitative Biology 2014-03-26 Elmar Peise , Diego Fabregat-Traver , Paolo Bientinesi

For more than a century, scientists have been collecting behavioral data--an increasing fraction of which is now being publicly shared so other researchers can reuse them to replicate, integrate or extend past results. Although behavioral…

Neurons and Cognition · Quantitative Biology 2020-12-24 Aurélien Defossez , Morteza Ansarinia , Brice Clocher , Emmanuel Schmück , Paul Schrater , Pedro Cardoso-Leite

Matching statistics were introduced to solve the approximate string matching problem, which is a recurrent subroutine in bioinformatics applications. In 2010, Ohlebusch et al. [SPIRE 2010] proposed a time and space efficient algorithm for…

Data Structures and Algorithms · Computer Science 2023-01-16 Alessio Conte , Nicola Cotumaccio , Travis Gagie , Giovanni Manzini , Nicola Prezza , Marinella Sciortino

The search for meaningful structure in biological data has relied on cutting-edge advances in computational technology and data science methods. However, challenges arise as we push the limits of scale and complexity in biological problems.…

Summary: Longer sequencing reads, with at least 200 bases per template are now common. While traditional aligners have adopted new strategies to improve the mapping of longer reads, aligners specific to bisulfite-sequencing were optimized…

Genomics · Quantitative Biology 2014-05-14 Brent S. Pedersen , Kenneth Eyring , Subhajyoti De , Ivana V. Yang , David A. Schwartz

A weight based dynamic compression method has recently been proposed, which is especially suitable for the encoding of files with locally skewed distributions. Its main idea is to assign larger weights to closer to be encoded symbols by…

Data Structures and Algorithms · Computer Science 2021-05-24 Aharon Fruchtman , Yoav Gross , Shmuel T. Klein , Dana Shapira

Minimum redundancy among different elements of an embedding in a latent space is a fundamental requirement or major preference in representation learning to capture intrinsic informational structures. Current self-supervised learning…

Machine Learning · Computer Science 2022-07-19 Chuang Niu , Ge Wang