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Causal inference with observational data critically relies on untestable and extra-statistical assumptions that have (sometimes) testable implications. Well-known sets of assumptions that are sufficient to justify the causal interpretation…

Methodology · Statistics 2024-02-20 Pablo Geraldo Bastías

To discover new drugs is to seek and to prove causality. As an emerging approach leveraging human knowledge and creativity, data, and machine intelligence, causal inference holds the promise of reducing cognitive bias and improving decision…

Quantitative Methods · Quantitative Biology 2025-04-09 Tom Michoel , Jitao David Zhang

Real world observational data, together with causal inference, allow the estimation of causal effects when randomized controlled trials are not available. To be accepted into practice, such predictive models must be validated for the…

Causal inference studies whether the presence of a variable influences an observed outcome. As measured by quantities such as the "average treatment effect," this paradigm is employed across numerous biological fields, from vaccine and drug…

Discovering causal relationships in complex socio-behavioral systems is challenging but essential for informed decision-making. We present Upload, PREprocess, Visualize, and Evaluate (UPREVE), a user-friendly web-based graphical user…

Machine Learning · Computer Science 2023-07-27 Suraj Jyothi Unni , Paras Sheth , Kaize Ding , Huan Liu , K. Selcuk Candan

Improving public policy is one of the key roles of governments, and they can do this in an evidence-based way using administrative data. Causal inference for observational data improves on current practice of using descriptive or predictive…

Applications · Statistics 2023-01-18 Elena Tartaglia , Peter Rankin

For a given causal question, it is important to efficiently decide which causal inference method to use for a given dataset. This is challenging because causal methods typically rely on complex and difficult-to-verify assumptions, and…

Machine Learning · Computer Science 2023-11-09 Shantanu Gupta , Cheng Zhang , Agrin Hilmkil

Two-way fixed effects (TWFE) models are widely used in political science to establish causality, but recent methodological discussions highlight their limitations under heterogeneous treatment effects (HTE) and violations of the parallel…

Methodology · Statistics 2026-02-03 Albert Chiu , Xingchen Lan , Ziyi Liu , Yiqing Xu

Predictive models learned from historical data are widely used to help companies and organizations make decisions. However, they may digitally unfairly treat unwanted groups, raising concerns about fairness and discrimination. In this…

Machine Learning · Computer Science 2018-03-07 Yongkai Wu , Lu Zhang , Xintao Wu

Human decision-making heavily relies on active sensing, a well-documented cognitive behaviour for evidence gathering to accommodate ever-changing environments. However, its operational mechanism in the real world remains non-trivial.…

Artificial Intelligence · Computer Science 2026-01-09 Hongliang Lu , Yunmeng Liu , Junjie Yang

The research questions that motivate transportation safety studies are causal in nature. Safety researchers typically use observational data to answer such questions, but often without appropriate causal inference methodology. The field of…

Applications · Statistics 2011-07-26 Vishesh Karwa , Aleksandra B. Slavković , Eric T. Donnell

The recent emergence of Medical Large Vision Language Models (Med-LVLMs) has enhanced medical diagnosis. However, current Med-LVLMs frequently encounter factual issues, often generating responses that do not align with established medical…

Machine Learning · Computer Science 2024-10-18 Peng Xia , Kangyu Zhu , Haoran Li , Hongtu Zhu , Yun Li , Gang Li , Linjun Zhang , Huaxiu Yao

Understanding causal mechanisms across different populations is essential for designing effective public health interventions. Recently, difference graphs have been introduced as a tool to visually represent causal variations between two…

Artificial Intelligence · Computer Science 2025-02-18 Charles K. Assaad

Shortcut learning, in which models make use of easy-to-represent but unstable associations, is a major failure mode for robust machine learning. We study a flexible, causally-motivated approach to training robust predictors by discouraging…

Machine Learning · Computer Science 2022-02-24 Maggie Makar , Ben Packer , Dan Moldovan , Davis Blalock , Yoni Halpern , Alexander D'Amour

The causal assumptions, the study design and the data are the elements required for scientific inference in empirical research. The research is adequately communicated only if all of these elements and their relations are described…

Methodology · Statistics 2015-05-01 Juha Karvanen

Cross-domain recommendation forms a crucial component in recommendation systems. It leverages auxiliary information through source domain tasks or features to enhance target domain recommendations. However, incorporating inconsistent source…

Information Retrieval · Computer Science 2025-10-17 Zhibo Wu , Yunfan Wu , Lin Jiang , Ping Yang , Yao Hu

Meta-analysis, by synthesizing effect estimates from multiple studies conducted in diverse settings, stands at the top of the evidence hierarchy in clinical research. Yet, conventional approaches based on fixed- or random-effects models…

Scientific discovery catalyzes human intellectual advances, driven by the cycle of hypothesis generation, experimental design, evaluation, and assumption refinement. Central to this process is causal inference, uncovering the mechanisms…

Machine Learning · Computer Science 2025-09-26 Ivaxi Sheth , Sahar Abdelnabi , Mario Fritz

Causal inference is a critical research topic across many domains, such as statistics, computer science, education, public policy and economics, for decades. Nowadays, estimating causal effect from observational data has become an appealing…

Methodology · Statistics 2020-02-10 Liuyi Yao , Zhixuan Chu , Sheng Li , Yaliang Li , Jing Gao , Aidong Zhang

Inducing causal relationships from observations is a classic problem in machine learning. Most work in causality starts from the premise that the causal variables themselves are observed. However, for AI agents such as robots trying to make…

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